Ultrasound diagnosis of thymic hemorrhage in an infant with late-onset hemorrhagic disease

Urvoas, E.; Pariente, D.; Rousset, André; Victor, D. de; Leblanc, Antoine

doi:10.1007/bf02020161

Cited by 12 publications

(6 citation statements)

References 7 publications

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“…Imaging findings in the nine cases of SHNT in perinatal and infantile period [3][4][5][6][7][8][9], this report included, are summarized in Table 1-2. Four of them were presented in a very early neonatal period and the other five cases were presented in an early infantile period (between the age of 4 weeks and 4 months).…”

Section: Discussionmentioning

confidence: 99%

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Imaging findings of spontaneous thymic hemorrhage in infancy: Case report and literature review

et al. 2020

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The authors report imaging findings of spontaneous thymic hemorrhage, which is a rare entity in infancy, in a 4-month-old boy with congenital factor VII deficiency presented with acute respiratory distress and anemia. Widening of superior mediastinum and left pleural effusion were detected on the chest radiograph. Ultrasound and computed tomography of the chest revealed diffusely enlarged thymus with heterogeneous parenchyma from poorly-defined areas of altered echogenicity or attenuation. Vascular flow was depicted within the abnormal thymus in color-mode sonography. The spontaneous involution of thymic abnormality seen on serial ultrasonography confirmed the diagnosis of thymic hemorrhage, resulting in avoidance of further unnecessary imaging or invasive procedure.

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Section: Discussionmentioning

confidence: 99%

“…The management of an infantile thymic hemorrhage usually started with normalization of coagulation indices by giving vitamin K and fresh frozen plasma, and adding packed red cell to the anemic ones [3][4][5][6][7][8][9]. The coagulopathy was usually corrected within 6-24 hours.…”

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confidence: 99%

Imaging findings of spontaneous thymic hemorrhage in infancy: Case report and literature review

et al. 2020

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“…Then 2 cases of spontaneous thymic haemorrhage with positive outcome after surgery are described in 1974 by Woolley et al [ 10 ]. Several years after Urvoas et al [ 7 ] presented a case of spontaneous thymic haemorrhage in a 4-week-old boy, with good resolution after medical treatment. In the case reported by Walsh et al [ 9 ] in 1996, the newborn showed severe neonatal respiratory distress, which led to death at a few hours of age.…”

Section: Discussionmentioning

confidence: 99%

Massive thymic hemorrhage and hemothorax occurring in utero

et al. 2015

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Background Thymic enlargement is a common and physiological finding in children and neonates’ X-rays, but it is usually asymptomatic. Occasionally it can cause respiratory distress. In most cases the aetiology of this expansion remains unclear and it is diagnosed as a thymic hyperplasia. True thymic hyperplasia is defined as a gland expansion, both in size and weight, while maintaining normal microscopic architecture. Often it is a diagnosis of exclusion and prognosis is good.Thymic haemorrhage is an unusual condition related to high foetal and neonatal mortality.Case PresentationWe report a case of spontaneous massive thymic haemorrhage in a newborn developing at birth acute respiratory distress associated with severe bilateral haemothorax.Thymic enlargement was evident after pleural evacuation and confirmed by radiographic, Computed Tomography (CT) images and Magnetic Resonance Imaging (MRI) sequences. The spontaneous resolution of this enlargement seen with CT scan and MRI sequences suggested a thymic haemorrhage; surgery was not necessary.ConclusionThymic haemorrhage should be considered in newborn infants with pleural effusion, mediastinal space enlargement and Respiratory Distress.

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“…A Medline search revealed 6 case reports. 1,2,[6][7][8][9] Two of the cases presented immediately after delivery and were caused by early onset VKDB. 7,8 Both received IM vitamin K prophylaxis.…”

Section: Commentarymentioning

confidence: 99%

“…Two other cases, as in ours, were caused by late-onset VKDB. 1,2 One received "the usual prophylactic dose of vitamin K1." He was a premature infant born at 36 weeks gestation and weight 2200 g at birth.…”

Section: Commentarymentioning

confidence: 99%