Ultrasound double contour sign and gout

Chen, Y-H.; Chen, Lu; Cc, Chang

doi:10.1093/qjmed/hcx154

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Pineda et al showed that the double-contour sign was found in almost 25% of MTP 1 joints (higher than any other kinds of joints) of gout patients [37]. Previous studies indicate that the double-contour sign and tophi are the two classical manifestations of urate deposition in joints of gout patients [16, 17, 38]. However, based on a meta-analysis of the diagnostic accuracy for US, Young et al showed that US signs of tophi and the double-contour sign were not sensitive in gout patients [39].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the US detection, the joint and tendon subclinical involvement are proved to be risk factors of gouty arthritis [15]. US double-contour sign is a specific manifestation of urate deposition in gouty arthritis [16, 17]. The American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR)-gout have already clarified the association between US and double-contour sign [18].…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for the formation of double-contour sign and tophi in gout

Sun

Tian

et al. 2019

J Orthop Surg Res

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Background This study aimed to confirm the diagnostic accuracy of ultrasound (US) on gout and explore the potential risk factors for double-contour sign and tophi formation in gout patients. Methods The US analyses were performed on all knee, ankle, and first metatarsophalangeal (MTP 1) joints to reveal the type and location of lesions. While a questionnaire and blood biochemical index were used to explore the potential risk factors for double-contour sign and tophi in gout, the SPSS17.0 software was used for statistical analysis in the present study. Results Totally, 117 gout patients with 702 joints (38 lesions in knee joint, 93 lesions in ankle joint, and 112 lesions in MTP 1 joint) were enrolled in current analyses. Double-contour sign and joint effusion were the two most outstanding lesion manifestations in knee joints and ankle joints. Tophi and double-contour sign were the two most outstanding lesion manifestations in TMP 1 joints. Moreover, factors including uric acid (UA) level and the highest blood UA were potential risk factors of the double-contour sign, while age and history of US were potential risk factors for tophi. Conclusion US was effective on the joints of gout patients. There was US sensitivity for tophi and double-contour sign in MTP 1 joints. The double-contour sign was a potential specific manifestation in knee joints and ankle joints. Furthermore, UA and highest blood UA level were potential risk factors for double-contour sign, while age and US history were potential risk factors for tophi.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk factors for the formation of double-contour sign and tophi in gout

Sun

Tian

et al. 2019

J Orthop Surg Res

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Differential Diagnosis of Acute and Chronic Gouty Arthritis by Multijoint Ultrasound

Deng

Dang

Liu

et al. 2021

Ultrasound in Medicine & Biology

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Prevalence of Ultrasonographical Evidence of Gout in Psoriatic Arthritis “Psout”: Across-Sectional Study

Antony,

Sankarlingam,

Chilukuri

et al. 2023

Medical Journal of Dr. D.Y. Patil Vidyapeeth

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Background and Objectives: Psoriatic arthritis (PsA) and gout are conditions sharing several common risk factors. Serum uric acid levels are commonly raised in both, and it is observed that many patients presenting with gout have either clinical or family history of psoriasis. There are case report of overlapping PsA and gout called “Psout.” So the objective of this study was to find out ultrasonographic features of gout in patients with PsA. Methods: This was a prospective observational study conducted on 105 PsA patients. Serum uric acid and ultrasonography (USG) with color Doppler of the affected joint were performed to look for the presence of the double contour (DC) sign, snowstorm sign, and erosion that is specific for gout. The sensitivity of “tophus,” “snowstorm,” and the DC sign-on USG were 46%, 30.3%, and 60.1%, while the specificity was 94.9%, 90.9%, and 91.4%, respectively, for gouty arthritis. The sensitivity, specificity, positive predictive value, and negative predictive value of hyperuricemia (uric acid levels >6.8 mg/dL) were compared with USG findings in diagnosis of psout. Results: The prevalence of gout in PsA was 11.4% (12/105); 10/12, 2/12, 6/12, and 1/12 had DC sign, tophi, erosions, and snowstorm appearance, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of hyperuricemia in diagnosis of gout in PsA was 33.3%, 86%, 23.5%, and 90.9%, respectively. Conclusion: Psoriasis and gout can co-exist or mimic each other. Good presence of DC sign-on USG is a noninvasive method to diagnose gout in PsA patients. Those patients not responding to treatment for PsA may have co-existing gout, so we recommend USG in all patients with PsA, especially if they are not responding to treatment.

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Ultrasound double contour sign and gout

Cited by 3 publications

References 2 publications

Risk factors for the formation of double-contour sign and tophi in gout

Risk factors for the formation of double-contour sign and tophi in gout

Differential Diagnosis of Acute and Chronic Gouty Arthritis by Multijoint Ultrasound

Prevalence of Ultrasonographical Evidence of Gout in Psoriatic Arthritis “Psout”: Across-Sectional Study

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