Ultrasound-driven 4D MRI

Giger, Alina; Stadelmann, Marc A.; Preiswerk, Frank; Jud, Christoph; Luca, Valéria De; Celicanin, Zarko; Bieri, Oliver; Salomir, Rarès; Cattin, Philippe C.

doi:10.1088/1361-6560/aaca1d

Cited by 9 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior work has used retrospective binning approaches to reconstruct 4D MR using external surrogates such as belt respirations sensors [48] or internal surrogates such as body area [49,50], mutual information [51], manifold learning [52], and deformation fields of interleaved navigator slices [53]. More recently, internal surrogates captured by ultrasound imaging have also been used for retrospective binning [54]. Second, with a matching probe position, ultrasound scans will be acquired in real-time during treatment and rapidly matched to the pre-treatment ultrasound and MR volumes.…”

Section: Discussionmentioning

confidence: 99%

First-in-human imaging using a MR-compatible e4D ultrasound probe for motion management of radiotherapy

et al. 2021

View full text Add to dashboard Cite

Respiration-induced tumor or organ positional changes can impact the accuracy of external beam radiotherapy. Motion management strategies are used to account for these changes during treatment. The authors report on the development, testing, and first-in-human evaluation of an electronic 4D (e4D) MR-compatible ultrasound probe that was designed for hands-free operation in a MR and linear accelerator (LINAC) environment. Methods: Ultrasound components were evaluated for MR compatibility. Electromagnetic interference (EMI) shielding was used to enclose the entire probe and a factory-fabricated cable shielded with copper braids was integrated into the probe. A series of simultaneous ultrasound and MR scans were acquired and analyzed in five healthy volunteers. Results: The ultrasound probe led to minor susceptibility artifacts in the MR images immediately proximal to the ultrasound probe at a depth of <10 mm. Ultrasound and MR-based motion traces that were derived by tracking the salient motion of endogenous target structures in the superior-inferior (SI) direction demonstrated good concordance (Pearson correlation coefficients of 0.95-0.98) between the ultrasound and MRI datasets. Conclusion:We have demonstrated that our hands-free, e4D probe can acquire ultrasound images during a MR acquisition at frame rates of approximately 4 frames per second (fps) without impacting either the MR or ultrasound image quality. This use of this technology for interventional procedures (e.g. biopsies and drug delivery) and motion compensation during imaging are also being explored.

show abstract

Section: Discussionmentioning

confidence: 99%

First-in-human imaging using a MR-compatible e4D ultrasound probe for motion management of radiotherapy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The advantages of this approach are that it does not rely on gating and thus supports imaging events that do not occur repeatedly, i.e., events that are not periodic. The disadvantages of this approach are its low temporal and spatial resolution [6,7] and its relatively small FOV, rendering it impossible to capture the respiratory motion of large organs like the liver.…”

Section: Related Workmentioning

confidence: 99%

4D MRI: Robust sorting of free breathing MRI slices for use in interventional settings

et al. 2020

View full text Add to dashboard Cite

We aim to develop a robust 4D MRI method for large FOVs enabling the extraction of irregular respiratory motion that is readily usable with all MRI machines and thus applicable to support a wide range of interventional settings. Method We propose a 4D MRI reconstruction method to capture an arbitrary number of breathing states. It uses template updates in navigator slices and search regions for fast and robust vessel cross-section tracking. It captures FOVs of 255 mm x 320 mm x 228 mm at a spatial resolution of 1.82 mm x 1.82 mm x 4mm and temporal resolution of 200ms. A total of 37 4D MRIs of 13 healthy subjects were reconstructed to validate the method. A quantitative evaluation of the reconstruction rate and speed of both the new and baseline method was performed. Additionally, a study with ten radiologists was conducted to assess the subjective reconstruction quality of both methods. Results Our results indicate improved mean reconstruction rates compared to the baseline method (79.4% vs. 45.5%) and improved mean reconstruction times (24s vs. 73s) per subject. Interventional radiologists perceive the reconstruction quality of our method as higher compared to the baseline (262.5 points vs. 217.5 points, p = 0.02). Conclusions Template updates are an effective and efficient way to increase 4D MRI reconstruction rates and to achieve better reconstruction quality. Search regions reduce reconstruction time. These improvements increase the applicability of 4D MRI as a base for seamless support of interventional image guidance in percutaneous interventions.

show abstract

“…The advantages of this approach are that it does not rely on gating and thus supports imaging events that do not occur repeatedly, i.e., events that are not periodic. The disadvantages of this approach are its low temporal and spatial resolution [6,7] and its relative small FOV, rendering it impossible to capture the respiratory motion of large organs like the liver.…”

Section: Related Workmentioning

confidence: 99%

4D MRI: Robust sorting of free breathing MRI slices for use in interventional settings

Gulamhussene,

Joeres,

Rak

et al. 2019

Preprint

View full text Add to dashboard Cite

We aim to develop a robust 4D MRI method for large FOVs enabling the extraction of irregular respiratory motion that is readily usable with all MRI machines and thus applicable to support a wide range of interventional settings. MethodWe propose a 4D MRI reconstruction method to capture an arbitrary number of breathing states. It uses template updates in navigator slices and search regions for fast and robust vessel cross-section tracking. It captures FOVs of 255 mm x 320 mm x 228 mm at a spatial resolution of 1.82 mm x 1.82 mm x 4mm and temporal resolution of 200ms. To validate the method, a total of 38 4D MRIs of 13 healthy subjects were reconstructed. A quantitative evaluation of the reconstruction rate and speed of both the new and baseline method was performed. Additionally, a study with ten radiologists was conducted to assess the subjective reconstruction quality of both methods. ResultsOur results indicate improved mean reconstruction rates compared to the baseline method (79.4% vs. 45.5%) and improved mean reconstruction times (24s vs. 73s) per subject. Interventional radiologists perceive the reconstruction quality of our method as higher compared to the baseline (262.5 points vs. 217.5 points, p=0.02). ConclusionsTemplate updates are an effective and efficient way to increase 4D MRI reconstruction rates and to achieve better reconstruction quality. Search regions reduce reconstruction time. These improvements increase the applicability of 4D MRI as base for seamless support of interventional image guidance in percutaneous interventions.

show abstract

Ultrasound-driven 4D MRI

Cited by 9 publications

References 31 publications

First-in-human imaging using a MR-compatible e4D ultrasound probe for motion management of radiotherapy

First-in-human imaging using a MR-compatible e4D ultrasound probe for motion management of radiotherapy

4D MRI: Robust sorting of free breathing MRI slices for use in interventional settings

4D MRI: Robust sorting of free breathing MRI slices for use in interventional settings

Contact Info

Product

Resources

About