Ultrasound‐Driven Non‐Metallic Fenton‐Active Center Construction for Extensive Chemodynamic Therapy

Abstract

Chemodynamic therapy (CDT) is an emerging tumor microenvironment‐responsive cancer therapeutic strategy based on Fenton/Fenton‐like reactions. However, the effectiveness of CDT is subject to the slow kinetic rate and non‐homogeneous distribution of H2O2. In this study, a conceptual non‐metallic “Fenton‐active” center construction strategy is proposed to enhance CDT efficiency using Bi0.44Ba0.06Na0.5TiO3 (BNBT‐6) nanocrystals. The separated charge carriers under a piezoelectric‐induced electric field synchronize the oxidation of H2O and reduction of H2O2, which consequently increases hydroxyl radical (·OH) yield even under low H2O2 levels. Moreover, acceptor doping induces electron‐rich oxygen vacancies to facilitate the dissociation of H2O2 and H2O and further promote ·OH generation. In vitro and in vivo experiments demonstrate that BNBT‐6 induces extensive intracellular oxidative stress and enhances cell‐killing efficiency by activating necroptosis in addition to the conventional apoptotic pathway. This study proposes a novel design approach for nanomaterials used in CDT and presents a new treatment strategy for apoptosis‐resistant tumors.This article is protected by copyright. All rights reserved

Rearranging Spin Electrons by Axial-Ligand-Induced Orbital Splitting to Regulate Enzymatic Activity of Single-Atom Nanozyme with Destructive d−π Conjugation

“…Comparatively, stronger fluorescence signals are observed in HeLa cells treated with H-MoN 5 @PtN 4 /C (Figure d-ii), indicating that H-MoN 5 @PtN 4 /C can catalyze cascade enzymatic reactions to generate high levels of O 2 •– . In the meantime, in situ • OH produced by the POD-like activity of H-MoN 5 @PtN 4 /C was recorded in cancer cells using aminophenol fluorescein (APF) as the fluorescent probe . As shown in Figure d-iii, the green fluorescence is strongest in cells after incubation with H-MoN 5 @PtN 4 /C, which is ascribed to synergistically enhanced POD-like performance generated by an axial coordination configuration.…”

“…In the meantime, in situ • OH produced by the POD-like activity of H-MoN 5 @PtN 4 /C was recorded in cancer cells using aminophenol fluorescein (APF) as the fluorescent probe. 45 As shown in Figure 5d-iii, the green fluorescence is strongest in cells after incubation with H-MoN 5 @PtN 4 /C, which is ascribed to synergistically enhanced POD-like performance generated by an axial coordination configuration. Consequently, the proposed H-MoN 5 @PtN 4 /C can effectively accumulate intracellular ROS (O 2…”

Engineering polyvinyl alcohol microspheres with capability for use in photothermal/chemodynamic therapy for enhanced transarterial chemoembolization

“…Researchers such as Bu and others have developed various chemodynamic therapy agents and demonstrated their significant effectiveness in inhibiting tumor progression. 20,21 However, some of these agents have a tendency to accumulate in normal tissues after intravenous administration, which can result in side effects during treatment. Therefore, engineering the design of microspheres to carry PTT and CDT agents allows for localized delivery, effectively addressing the challenges of TACE microspheres’ drug resistance and potential harm to normal tissues.…”