Ultrasound examination of the salivary glands in Sjogren’s disease

Torgashina, A.

doi:10.47360/1995-4484-2021-442-449

Naučno-praktičeskaâ revmatologiâ

2021

DOI: 10.47360/1995-4484-2021-442-449

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Ultrasound examination of the salivary glands in Sjogren’s disease

A. Torgashina¹

Abstract: The article discusses the importance of ultrasound examination of the salivary glands in Sjogren’s disease for the diagnosis, as well as for assessing the activity of the disease. The characteristics of the main ultrasound changes in the salivary glands and the pathogenetic reasons of these changes are given. The results of studies of the dynamics of changes in ultrasound parameters both in patients not receiving treatment and in the presence of various methods of therapy are presented. The paper also provides… Show more

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Cited by 2 publications

References 45 publications

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Ultrasonography of the salivary glands in Sjögren's disease: own data analysis

Khvan,

Torgashina,

Volkov

et al. 2024

Sovremennaâ revmatologiâ

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Objective: to investigate feasibility of using ultrasonography (US) to evaluate structural changes of salivary glands (SG) in patients with Sjögren's disease (SD).Material and methods. The study included 159 patients who were examined in V.A. Nasonova Research Institute of Rheumatology from 2016 to 2022 who met V.A. Nasonova Research Institute of Rheumatology 2001, and/or ACR 2012, and/or ACR/EULAR 2016 criteria for SD, and who had not previously received immunosuppressive therapy. All patients underwent a comprehensive classical examination (ophthalmological, dental, immunological) to diagnose SD. Disease activity was determined using ESSDAI index. US of the parotid gland (PG) and submandibular SGs was performed using a GE LOGIQ 9 device, and the images obtained were scored according to the OMERACT SGUS scoring system (SGUS SS).Results and discussion. All SGUS SS scores statistically significantly correlated (p<0.05) with mouth sicca symptoms, enlargement of PG, ESSDAI activity index, presence of lymphohistiocytic infiltrate and focus score in labial SG biopsy, and parenchymatous parotitis according to sialography. No significant correlation was found with the results of sialometry. There was a significant correlation between the changes detected by US and sialography (r=0.422; p=0.001). Considering the data obtained, the consistency of the results of the different examination methods was analyzed. Bland-Altman diagrams were created to reflect the dependence of the differences between the results of US and sialography. At various stages of the comparison, not all data points were within the standardized range. In addition, 5% of the parameters were not within the interval of two standard deviations. The Bland-Altman analysis revealed a systematic discrepancy indicating a low degree of agreement between the two methods for determining structural changes in SG. According to the ROC analysis, sensitivity of ultrasound was 94% and specificity 51%. The area under the curve (AUC) was 0.787 (95% confidence interval 0.700–0.875).Conclusion. SG US and sialography are not interchangeable, but complement each other in the assessment of SG structure. SG US is a safer and non-invasive method of SG examination that does not require contrast agent administration and is likely to play an important role in the dynamic monitoring of patients during the therapy. However, sialography is a more accurate method of diagnostics and assessment of the extent of SG lesions.

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Ultrasonography of the salivary glands in Sjögren's disease: own data analysis

Khvan,

Torgashina,

Volkov

et al. 2024

Sovremennaâ revmatologiâ

View full text Add to dashboard Cite

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Integrative approach to diagnosis of lymphoproliferative disease during long-term Sjogren’s disease. Clinical observation

Zeynalovа

Аллахвердиева

Ryabukhina

et al. 2023

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During long-term autoimmune processes, most commonly in patients with Sjogren’s disease (SD), lymphoproliferative disorders (LPD) can develop. The risk of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) with involvement of parotid salivary glands is increased 1,000-fold compared to other immunomorphological variants. Some studies show that the main factors predisposing patients with SD to LPD are long-term enlargement of parotid salivary glands, generalized lymphadenopathy, cryoglobulinemic purpura. Application of an integrative approach to LDP diagnosis in patients with SD, identification of high-risk group for this malignant neoplasm promote its early detection.A clinical observation of a female patients with long-term SD which was diagnosed along with MALT lymphoma using an integrative approach to diagnosis of both diseases is presented.

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Ultrasound examination of the salivary glands in Sjogren’s disease

Cited by 2 publications

References 45 publications

Ultrasonography of the salivary glands in Sjögren's disease: own data analysis

Ultrasonography of the salivary glands in Sjögren's disease: own data analysis

Integrative approach to diagnosis of lymphoproliferative disease during long-term Sjogren’s disease. Clinical observation

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