Ultrasound features of abdominal thrombosis in COVID 19 patients

Dong, Yi; Qiu, Yue; Cao, Jin; Fan, Peili; Wang, Wenping; Fleischmann, Johannes; Jung, Ernst-Michael

doi:10.3233/ch-221487

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…CTV and contrast enhanced ultrasound (CEUS) are both often used method for the detection of venous thromboses [ 20 ]. CEUS can sensitively depict the microcirculation perfusion within the tissue, overcoming the disadvantage of color ultrasound is difficult to show fine blood flow.…”

Section: Discussionmentioning

confidence: 99%

Thrombosis density ratio can predict the occurrence of pulmonary embolism and post-thrombotic syndrome in lower-extremity deep vein thrombosis patients

Yao,

Lin,

Shi

et al. 2024

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OBJECTIVE: Deep vein thrombosis (DVT) formation of lower extremities can lead to serious complications including pulmonary embolism (PE) and chronic post-thrombotic syndrome (PTS). We aimed to explore the relationship between the ratio of thrombotic density and the occurrence of PE and PTS in patients with DVT of the lower extremities. METHODS: A retrospective analysis was conducted in patients who performed computed tomography venography, dividing into DVT with PE group (54 patients) and DVT-alone group (34 patients), The clinical data were recorded. Univariate and multivariate logistic regression analysis were used to analysis variables associated with PE. The ability of thrombosis density ratio and Wells score to diagnose PE was evaluated by using the receiver operating characteristic curve (ROC) area under the curve (AUC). According to the treatment and follow-up results, subgroup analysis was performed, and the Villata score was used to determine the presence or absence of PTS and its severity. RESULTS: Compare with the DVT-alone group, more patients had dyspnea and chest pain in the DVT with PE group. DVT with PE group had lower the percentage of neutrophils, white blood cell count and platelet count, while had higher blood cell count, D-dimer, wells score, thrombus and thrombus density ratio. Multivariate logistic analysis showed that percentage of neutrophils (OR(95% CIs)=1.15 (1.01,1.31), P = 0.040), platelets (OR(95% CIs)=0.96 (0.93,0.99), P = 0.011), and thrombus density ratio (OR(95% CIs)=5.99 (1.96,18.35), P = 0.002) are independent predictors of PE. The Wells score and thrombosis density ratio were consistent in the diagnostic efficacy of PE. In the subgroup analysis, there was a relevance between the ratio of thrombosis density and the Villalta score. CONCLUSION: Percentage of neutrophils, platelets, and thrombus density ratio are independent predictors of PE. The thrombosis density of DVT patients may be an index to predict the risk of PE and PTS in DVT patients.

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Section: Discussionmentioning

confidence: 99%

Thrombosis density ratio can predict the occurrence of pulmonary embolism and post-thrombotic syndrome in lower-extremity deep vein thrombosis patients

Yao,

Lin,

Shi

et al. 2024

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“…It showed that hospitalised COVID-19 patients can experience thromboembolic consequences. The early and precise diagnosis of these issues can be achieved with multimodality ultrasound tests [28].…”

Section: Effect Of Sars-cov-2 On Thrombotic Processes In the Whole Bo...mentioning

confidence: 99%

Oral manifestations of COVID-19: A review

Anarthe

Mani

Saklecha

2023

JCB

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An important indicator of general health, well-being, and quality of life is oral health. The SARS-CoV-2 virus, which has been discovered to have a number of adverse effects. One of the earliest tissue areas to become infected by the virus and undergo alterations is the oral cavity. Oral manifestations included ulcer, erosion, bulla, vesicle, pustule, fissured or depapillated tongue, macule, papule, plaque, pigmentation, halitosis, white patches, haemorrhagic crust, necrosis, petechiae, swelling, erythema, and spontaneous bleeding. The tongue (38%), labial mucosa (26%), and palate (22%) were the three most typical sites of involvement. Aphthous stomatitis, herpetiform lesions, candidiasis, vasculitis, mucositis, drug eruption, necrotizing periodontal disease, angina bullosa-like, angular cheilitis, atypical sweet syndrome, and Melkerson-Rosenthal syndrome were suggested diagnoses for the lesions. In 68% of instances, oral lesions were symptomatic. There were almost equally as many oral lesions in both sexes (49% female and 51% male). More extensive and severe oral lesions were present in patients who were older and who had COVID-19 diseases that were more severe. The most significant risk factors for the development of oral lesions in COVID-19 patients include poor oral hygiene, opportunistic infections, stress, immunosuppression, vasculitis, and hyper-inflammatory response. It is crucial to identify any changes in the mucosa in COVID-19 patients and administer assertive treatment to prevent complications. Patients should also try to maintain adequate oral hygiene throughout the course of the illness to prevent the colonisation of opportunistic microorganisms and to prevent complications both orally and systemically.

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“…COVID-19 distinguishes itself by oscillation between thrombotic and fibrinolytic phase which leads to micro and macro thrombi and consumption of important products for coagulation [4][5][6]. This high build up and lysis of thrombi [7,8] is shown by highly elevated d-dimers and a steady consumption of fibrinogen. Elevated d-dimers on admission in COVID-19 patients are associated with worsen prognosis 12].…”

Section: Introductionmentioning

confidence: 99%

Influence of Covid-19 disease on hemostasis dynamics during extracorporeal membrane oxygenation (ECMO)1

Rother

Gehron

Brenck

et al. 2024

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INTRODUCTION: COVID-19 causes a considerable degradation of pulmonary function to the point of an acute respiratory distress syndrome (ARDS). Over the course of the disease the gas exchange capability of the lung can get impaired to such an extent that extracorporeal membrane oxygenation (ECMO) is needed as a life-saving intervention. In patients COVID-19 as well as ECMO may cause severe coagulopathies which manifest themselves in micro and macro thrombosis. Previous studies established D-dimers as a marker for critical thrombosis of the ECMO system while on admission increased D-dimers are associated with a higher mortality in COIVD-19 patients. It is therefore crucial to determine if COVID-19 poses an increased risk of early thrombosis of the vital ECMO system. METHODS: 40 patients who required ECMO support were enrolled in a retrospective analysis and assigned into 2 groups. The COVID group consist of 20 COVID-19 patients who required ECMO support (n = 20), whereas 20 ECMO patients without COVID-19 were assigned to the control group. D-dimers, fibrinogen, antithrombin III (AT III), lactate dehydrogenase (LDH) and platelet count were analysed using locally weighted scatterplot smoothing and MANOVAs. RESULTS: The analysis of both groups shows highly significant differences in the dynamics of hemostasis. The increase in D-dimers that is associated with thrombosis of the ECMO systems occurs in COVID-19 patients around 2 days earlier (p = 2,8115 10–11) while fibrinogen is consumed steadily. In the control group fibrinogen levels increase rapidly after ten days with a plateau phase of around five days (p = 1,407 10–3) . Both groups experience a rapid increase in AT III after start of support by ECMO (p = 5,96 10–15). In the COVID group platelet count decreased from 210 giga/l to 130 giga/l within eight days, while in the same time span in the control group platelets decreased from 180 giga/l to 105 giga/l (p = 1,1 10–15). In both groups a marked increase in LDH beyond 5000 U/l occurs (p = 3,0865 10–15). CONCLUSION: The early increase in D-dimers and decrease in fibrinogen suggests that COVID-19 patients bear an increased risk of early thrombosis of the ECMO system compared to other diseases treated with ECMO. Additionally, the control group shows signs of severe inflammation 10 days after the start of ECMO which were absent in COVID-19 patients.

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Ultrasound features of abdominal thrombosis in COVID 19 patients

Cited by 8 publications

References 29 publications

Thrombosis density ratio can predict the occurrence of pulmonary embolism and post-thrombotic syndrome in lower-extremity deep vein thrombosis patients

Thrombosis density ratio can predict the occurrence of pulmonary embolism and post-thrombotic syndrome in lower-extremity deep vein thrombosis patients

Oral manifestations of COVID-19: A review

Influence of Covid-19 disease on hemostasis dynamics during extracorporeal membrane oxygenation (ECMO)1

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