Ultrasound for ankle and foot pathologies in early rheumatoid arthritis

Huang, Yi Hsiang; Chen, Yu‐Han; Yong, Su‐Boon; Sheng‐Kai, Kevin

doi:10.1111/1756-185x.14593

Cited by 1 publication

(2 citation statements)

References 31 publications

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“…Imaging modalities such as ultrasound (US) [ 13 , 14 ] and magnetic resonance imaging (MRI) have emerged as valuable tools for the detection of early inflammatory changes in the body, even before the onset of clinical synovitis [ 15 , 16 ]. Imaging modalities such as US and MRI [ 17 ] have emerged as valuable tools for detecting early inflammatory changes before the onset of clinical synovitis [ 18 , 19 , 20 ]. High-frequency ultrasound has shown promise as a cost-effective, non-invasive, and widely available method for the detection of mild synovitis and in predicting the progression to clinical arthritis [ 9 , 19 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Imaging modalities such as US and MRI [ 17 ] have emerged as valuable tools for detecting early inflammatory changes before the onset of clinical synovitis [ 18 , 19 , 20 ]. High-frequency ultrasound has shown promise as a cost-effective, non-invasive, and widely available method for the detection of mild synovitis and in predicting the progression to clinical arthritis [ 9 , 19 , 21 ]. However, previous research on the effectiveness of US in early disease detection has been limited by small sample sizes and variability [ 17 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Predicting Rheumatoid Arthritis Development Using Hand Ultrasound and Machine Learning—A Two-Year Follow-Up Cohort Study

Daskareh,

Vakilpour,

Barzegar-Golmoghani

et al. 2024

Diagnostics

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Background: The early diagnosis and treatment of rheumatoid arthritis (RA) are essential to prevent joint damage and enhance patient outcomes. Diagnosing RA in its early stages is challenging due to the nonspecific and variable clinical signs and symptoms. Our study aimed to identify the most predictive features of hand ultrasound (US) for RA development and assess the performance of machine learning models in diagnosing preclinical RA. Methods: We conducted a prospective cohort study with 326 adults who had experienced hand joint pain for less than 12 months and no clinical arthritis. We assessed the participants clinically and via hand US at baseline and followed them for 24 months. Clinical progression to RA was defined according to the ACR/EULAR criteria. Regression modeling and machine learning approaches were used to analyze the predictive US features. Results: Of the 326 participants (45.10 ± 11.37 years/83% female), 123 (37.7%) developed clinical RA during follow-up. At baseline, 84.6% of the progressors had US synovitis, whereas 16.3% of the non-progressors did (p < 0.0001). Only 5.7% of the progressors had positive PD. Multivariate analysis revealed that the radiocarpal synovial thickness (OR = 39.8), PIP/MCP synovitis (OR = 68 and 39), and wrist effusion (OR = 12.56) on US significantly increased the odds of developing RA. ML confirmed these US features, along with the RF and anti-CCP levels, as the most important predictors of RA. Conclusions: Hand US can identify preclinical synovitis and determine the RA risk. The radiocarpal synovial thickness, PIP/MCP synovitis, wrist effusion, and RF and anti-CCP levels are associated with RA development.

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