Ultrasound for Drug/Gene Delivery

Huang, Shaoling; McPherson, David D.

doi:10.1016/b978-0-12-407722-5.00016-5

Cited by 8 publications

(6 citation statements)

References 100 publications

(99 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, secondary forces attract particles such as ultrasound contrast agents (agents used to increase local drug diffusivity across biological membranes) such as Imagent, SonoVue, Optison etc. 94 …”

Section: Recent Advances In Physical Methods Of Permeation Enhancemen...mentioning

confidence: 99%

Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement

Vaseem,

D’cruz,

Shetty

et al. 2023

Adv Pharm Bull

View full text Add to dashboard Cite

The skin is the body's largest organ and serves as a site of administration for various medications. Transdermal drug delivery systems have several advantages over traditional delivery systems. It has both local and systemic therapeutic properties. Controlled plasma drug levels, reduced dosing frequency, and avoidance of hepatic first-pass metabolism are just a few of these systems' advantages. To achieve maximum efficacy, it is critical to understand the kinetics, physiochemical properties of the drug moiety, and drug transport route. This manuscript focused on the principles of various physical means to facilitate transdermal drug delivery. Some examples are iontophoresis, electrophoresis, photomechanical waves, ultrasound, needleless injections, and microneedles. Mechanical, chemical, magnetic, and electrical energy are all used in physical methods. A major advantage of physical methods is their capability to abbreviate pain, which can be used for effective disease management. Further investigation should be carried out at the clinical level to understand these methods for effective drug delivery.

show abstract

Section: Recent Advances In Physical Methods Of Permeation Enhancemen...mentioning

confidence: 99%

Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement

Vaseem,

D’cruz,

Shetty

et al. 2023

Adv Pharm Bull

View full text Add to dashboard Cite

show abstract

“…These include the low contrast between organs or materials with similar echogenicities, such as the blood and the tissues surrounding the vasculature [2] , and the poor image quality arising from poorly vascularized tissues, such as tumours or regions with many small vessels with slow blood flow [3] . Clinically approved ultrasound contrast agents are microbubbles, which are comprised of a gaseous core and a thin, generally biocompatible shell, made of lipids, proteins, or polymers [4] , [5] . Due to their smaller sizes as compared to red blood cells (RBCs), microbubbles can traverse even the smallest capillaries, which aids in imaging these small blood vessels.…”

Section: Mainmentioning

confidence: 99%

Ultrasound-assisted fabrication of acoustically active, erythrocyte membrane “bubbles”

Vidallon

Tabor

Bishop

et al. 2021

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

“…The MI depends on the maximum value of peak negative pressure and the pulse center frequency of the ultrasound field, and can be used as a safety guide for ultrasound exposure to the body. For MIs <0.3, the acoustic amplitude is considered low, while MIs >0.3 and <0.7 may cause minor damage, and MIs >0.7 may have major bioeffects such as cavitation (Huang & McPherson, 2014;Sen, Tufekcioglu, & Koza, 2015). The mechanical effects on cells and tissues can elicit biological responses, one of which is the delivery of molecules across biological barriers.…”

Section: Ultrasoundmentioning

confidence: 99%

“…Naturally occurring cavitation bubbles arise when ultrasound with MIs>0.7 is applied to spots with lower tensile strength that contain gas nuclei capable of supporting the cavitation process (Huang & McPherson, 2014). These nuclei are in the form of gas pockets, gas bubbles or interfacial gaseous voids located at water-solid interface, and are transformed into cavitation bubbles during the exposure to acoustic pressure (Mørch, 2015;Junru Wu & Nyborg, 2008).…”

Section: Natural Cavitationmentioning

confidence: 99%

Regulation Of Endocytosis By Ultrasound And Microbubble Treatment: Potential For Controlled Cellular Delivery Of Drugs To Cancer Cells

Fekri¹

2021

Preprint

View full text Add to dashboard Cite

The delivery of therapeutics across biological barriers is a limiting factor in achieving ideal pharmacologic responses in patients. Modulating endocytic mechanisms with targeted, clinically-relevant interventions can increase intracellular delivery across biological barriers, and improve the efficacy of drugs. Ultrasound-microbubble (USMB) is a novel targeted delivery strategy that has shown promising potential in both diagnostic and therapeutic applications. The collective behaviour of microbubbles in the acoustic field can increase the plasma membrane permeability of surrounding cells, and enhance the delivery of therapeutics across biological barriers. USMB achieves the intracellular delivery of drugs through sonoporation and modulation of endocytic pathways, but the type of endocytic pathways and the mechanisms of activation were not known. I identified that, under distinct regulations, USMB enhances the rate of both clathrin-mediated endocytosis, as well as a non-receptor-mediated pathway responsible for internalizing bulk fluid into cells. I discovered that lysosome exocytosis and acidsphingomyelinase are required for the regulation of the clathrin-mediated pathway but not fluidphase endocytosis following USMB treatment. Given the potential of the clathrin-independent pathway to form high capacity carries for the uptake of fluids and therapeutics into cells, I aimed to identify the molecular identity of the proteins that drive the formation of non-clathrin coated vesicles following USMB treatment. I established that flotillins contribute to the USMB-induced vesicular uptake of fluid into cells, a phenomenon that depends on palmitoyltransferase DHHC5 and the Src-family kinase Fyn. Furthermore, I confirmed that USMB treatment can enhance the intracellular delivery of chemotherapeutic drugs such as cisplatin, and improve its therapeutic efficacy in a flotillin-dependent manner. This project established that both clathrin-mediated endocytosis and flotillin-dependent endocytosis can be modulated by clinically-relevant USMB treatments to enhance drug uptake and efficacy, revealing an important new strategy for targeted drug delivery in cancer treatment.

show abstract

Ultrasound for Drug/Gene Delivery

Cited by 8 publications

References 100 publications

Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement

Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement

Ultrasound-assisted fabrication of acoustically active, erythrocyte membrane “bubbles”

Regulation Of Endocytosis By Ultrasound And Microbubble Treatment: Potential For Controlled Cellular Delivery Of Drugs To Cancer Cells

Contact Info

Product

Resources

About