Ultrasound guidance and monitoring of laser‐based fat removal

Shah, Jay; Thomsen, Sharon; Milner, Thomas E.; Emelianov, Stanislav

doi:10.1002/lsm.20726

Cited by 3 publications

(1 citation statement)

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“…This imaging technique provides functional and morphological information for the tissues and organs, which could be applied to differentiate abnormal tissues from surrounding normal tissues and to detect pathologies such as cancer in the early stage. In addition, the combined ultrasound, photoacoustic and magneto-acoustic imaging technique can be used both to guide and to enhance photothermal therapy [15,16,18,19].…”

Section: Resultsmentioning

confidence: 99%

Combined photoacoustic and magneto-acoustic imaging

Mallidi

Mehrmohammadi

et al. 2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Ultrasound is a widely used modality with excellent spatial resolution, low cost, portability, reliability and safety. In clinical practice and in the biomedical field, molecular ultrasound-based imaging techniques are desired to visualize tissue pathologies, such as cancer. In this paper, we present an advanced imaging technique - combined photoacoustic and magneto-acoustic imaging - capable of visualizing the anatomical, functional and biomechanical properties of tissues or organs. The experiments to test the combined imaging technique were performed using dual, nanoparticle-based contrast agents that exhibit the desired optical and magnetic properties. The results of our study demonstrate the feasibility of the combined photoacoustic and magneto-acoustic imaging that takes the advantages of each imaging techniques and provides high sensitivity, reliable contrast and good penetrating depth. Therefore, the developed imaging technique can be used in wide range of biomedical and clinical application.

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Section: Resultsmentioning

confidence: 99%

Combined photoacoustic and magneto-acoustic imaging

Mallidi

Mehrmohammadi

et al. 2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Temperature Measurements

Pearce¹,

Valvano²,

Emelianov³

2010

Optical-Thermal Response of Laser-Irradiated Tissue

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Postischemic temperature, which modulates brain injury, is commonly determined via a rectal temperature (T rec ) probe. This procedure causes a stress-induced fever (SIF) in rodents that may aggravate injury or diminish the efficacy of a neuroprotectant. We continually measured core temperature (T core ) via an implanted telemetry probe and made 16 T rec measurements over 4 days in sham and ischemic gerbils (5 min bilateral carotid artery occlusion). Controls did not have T rec sampled, but T core was measured. Rectal temperature measurements predicted T core in sham and ischemic gerbils. The T rec measurements caused a SIF (1°C peak) in shams that did not habituate, whereas the SIF was initially absent and then increased over days in ischemic gerbils. Ischemic groups had similar CA1 injury (-32% remaining), presumably because T rec measurements only resulted in a significant SIF starting on day 2 postischemia, when cell death is less sensitive to hyperthermia. Caution is warranted with T rec measurements, since the resultant SIF occurs to different extents in normal and ischemic rodents. Furthermore, the SIF could vary according to many other factors, such as the type and severity of insult, the time and frequency of measurement, and drug treatment. Accordingly, postischemic T rec measurements should be replaced with telemetry probes.Key words: ischemia, stress-induced fever, hyperthermia, gerbil, rectal temperature.Résumé : La température postischémique, modulatrice de lésions cérébrales, est couramment évaluée à l'aide d'une sonde rectale. Cette procédure entraîne cependant une fièvre provoquée par le stress (FPS) chez les rongeurs, ce qui est susceptible d'aggraver les lésions ou de diminuer l'efficacité d'un neuroprotecteur. Nous avons mesuré, chez les gerbilles ischémiques (à la suite d'une occlusion bilatérale de la carotide d'une durée de 5 min) et chez les gerbilles té-moins, la température centrale de façon continue à l'aide d'une sonde télémétrique implantée, et nous avons fait la saisie de 16 températures rectales (T rec ). Ces mesures se sont effectuées sur une période de 4 jours. Nous avons uniquement mesuré la température centrale chez les groupes témoins. Les mesures de température rectale ont été utilisées pour prédire la température centrale chez les gerbilles ischémiques et les gerbilles témoins. La prise de température rectale a entraîné une FPS (hausse maximale de 1°C) chez les groupes témoins et les gerbilles de ce groupe ne se sont jamais accoutumées à cette manipulation. Par contre, cette fièvre, quoiqu'initialement absente, a augmenté graduellement chez les gerbilles ischémiques au cours de la période expérimentale. Les groupes de gerbilles ischémiques souffraient vraisemblablement du même type de lésion CA1 (~32 % du reste) puisque les mesures de T rec ont seulement démontré une FPS à la deuxième journée de postischémie, période à laquelle l'hypothermie est moins susceptible de provoquer la mort cellulaire. Il faut quand même être prudent en ce qui concerne l'utilisation de me...

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