Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat

Spugnini, Enrico P.; Menicagli, Francesco; Pettorali, Michela; Baldi, Alfonso

doi:10.4314/ovj.v7i1.8

Cited by 12 publications

(6 citation statements)

References 13 publications

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“…Even this type of therapy seems to be easily adaptable for every species, type of tumour and their localisation, [18][19][20][21][22][23][24][25][26][27][28][29] the tumour size remains a debatable subject at the moment. For example, in human medicine, the ECT is currently being used for the treatment of mast cell tumours, melanomas, squamous and basal cell carcinomas, Kaposi sarcomas, Merkel cell carcinomas, etc, but appears that only tumours smaller than 3 cm show good response rates.…”

Section: Discussionmentioning

confidence: 99%

Electrochemotherapy as treatment for generalised squamous cell carcinoma in a dog

Boncea

Cristea²,

Bourdeau

2019

Vet Record Case Reports

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Canine squamous cell carcinoma (cSCC) is the second most common cutaneous neoplasm in dogs. Treatment options are limited. Electrochemotherapy (ECT) has been proposed as an alternative treatment for many types of tumours. To describe the use of ECT as treatment for generalised cSCC. An adult dog (four years old) was diagnosed with generalised cSCC. There were 24 tumours with the size range of 0.3–3 cm. The biopsy revealed an infiltrate rich in epithelial squamous cells, associated with pyogranulomatous inflammation. ECT was elected as treatment of choice. Cisplatin was injected intratumorously. After five minutes, the electric pulses were applied. The complete tumour regression was noted four weeks after. The dog was still in complete remission, 20 months later. This is the first case reporting a complete long-term remission using ECT for generalised cSCC.

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Section: Discussionmentioning

confidence: 99%

Electrochemotherapy as treatment for generalised squamous cell carcinoma in a dog

Boncea

Cristea²,

Bourdeau

2019

Vet Record Case Reports

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“…ECT is especially suitable for the treatment of solid tumors in cases where animal owners decline surgical treatment, or when tumors are located in areas where complete removal would be impossible (e.g., tumors near large vessels, tumors of the head and limbs, perianal tumors) ( 12 ). In veterinary medicine, the first reports of the use of ECT for the treatment of deep-seated tumors were recently described for the treatment of nasal tumors and colorectal carcinomas in dogs and thymoma in a cat ( 20 , 41 – 43 ).…”

Section: Basic Principles Of Electroporation-based Treatments and Genmentioning

confidence: 99%

Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology

et al. 2020

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Electroporation is a method of inducing an increase in permeability of the cell membrane through the application of an electric field and can be used as a delivery method for introducing molecules of interest (e.g., chemotherapeutics or plasmid DNA) into cells. Electroporation-based treatments (i.e., electrochemotherapy, gene electrotransfer, and their combinations) have been shown to be safe and effective in veterinary oncology, but they are currently mostly recommended for the treatment of those solid tumors for which clients have declined surgery and/or radiotherapy. Published data show that electroporation-based treatments are also safe, simple, fast and cost-effective treatment alternatives for selected oral and maxillofacial tumors, especially small squamous cell carcinoma and malignant melanoma tumors not involving the bone in dogs. In these patients, a good local response to treatment is expected to result in increased survival time with good quality of life. Despite emerging evidence of the clinical efficacy of electroporation-based treatments for oral and maxillofacial tumors, further investigation is needed to optimize treatment protocols, improve clinical data reporting and better understand the mechanisms of patients' response to the treatment.

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“…Needle electrodes can be placed through the tumor tissue to a depth of 3 cm. In veterinary medicine, a depth of up to 7 cm has been achieved with ultra-sonographic guidance [ 74 ]. The penetration of the electric field depends on the distance between the electrodes and the distribution of the electric field.…”

Section: Clinical Applicationsmentioning

confidence: 99%

“…They focused on the molecular signatures of HPV- and HPV+ malignancies for the identification of specific biomarkers to guide treatment selection. Treatment for head and neck cancer may include surgery, radiotherapy, chemotherapy, targeted therapy (e.g., EGFR inhibitors), and immunotherapy (e.g., pembrolizumab (anti-PD-1) monotherapy) [ 74 ]. These therapies can be used alone or in combination, but in most cases, they have side effects.…”

Section: Treatment Of Solid Tumors With Ectmentioning

confidence: 99%

Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors

Condello

D'Avack

Spugnini³

et al. 2022

Cancers

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Electrochemotherapy (ECT) is one of the innovative strategies to overcome the multi drug resistance (MDR) that often occurs in cancer. Resistance to anticancer drugs results from a variety of factors, such as genetic or epigenetic changes, an up-regulated outflow of drugs, and various cellular and molecular mechanisms. This technology combines the administration of chemotherapy with the application of electrical pulses, with waveforms capable of increasing drug uptake in a non-toxic and well tolerated mechanical system. ECT is used as a first-line adjuvant therapy in veterinary oncology, where it improves the efficacy of many chemotherapeutic agents by increasing their uptake into cancer cells. The chemotherapeutic agents that have been enhanced by this technique are bleomycin, cisplatin, mitomycin C, and 5-fluorouracil. After their use, a better localized control of the neoplasm has been observed. In humans, the use of ECT was initially limited to local palliative therapy for cutaneous metastases of melanoma, but phase I/II studies are currently ongoing for several histotypes of cancer, with promising results. In this review, we described the preclinical and clinical use of ECT on drug-resistant solid tumors, such as head and neck squamous cell carcinoma, breast cancer, gynecological cancer and, finally, colorectal cancer.

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Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat

Cited by 12 publications

References 13 publications

Electrochemotherapy as treatment for generalised squamous cell carcinoma in a dog

Electrochemotherapy as treatment for generalised squamous cell carcinoma in a dog

Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology

Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors

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