Ultrasound-guided immunofunctional photoacoustic imaging for diagnosis of lymph node metastases

Dumani, Diego S.; Sun, In Cheol; Emelianov, Stanislav

doi:10.1039/c9nr02920f

Cited by 29 publications

(21 citation statements)

References 63 publications

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“…The tumor cell targeting of AuNPs mainly relies on the ligand and can be recognized by cancerous cells, such as Lam 67R [85] and GRP [118] human prostate tumors, and CCR5 and HER2 [65] for breast tumors. The stimuli-response includes exogenous stimuli, such as NIR [119], magnetic [120], ultrasound [121] and endogenous stimuli, such as Ph [56] and redox [122].…”

Section: Targetingmentioning

confidence: 99%

“…For immunotherapy, AuNPs can be loaded with immune target antibodies and stimulate the activation of immune cells. These antibodies include polyclonal anti-carcino-embryonic antigen (CEA) [126], monoclonal anti-HER2 [121] and so on. Dumani et al designed AuNPs coated with glycol-chitosan that can be taken up by immune cells and subsequently transported to the sentinel lymph node to detect metastases [121].…”

Section: Deliverymentioning

confidence: 99%

“…These antibodies include polyclonal anti-carcino-embryonic antigen (CEA) [126], monoclonal anti-HER2 [121] and so on. Dumani et al designed AuNPs coated with glycol-chitosan that can be taken up by immune cells and subsequently transported to the sentinel lymph node to detect metastases [121]. AuNPs can modified with nucleotide sequence for detecting [127], imaging [25] and therapy [26].…”

Section: Deliverymentioning

confidence: 99%

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The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment

Bai

Wang

Song

et al. 2020

IJMS

275

156

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Gold nanoparticles (AuNPs) have been widely studied and applied in the field of tumor diagnosis and treatment because of their special fundamental properties. In order to make AuNPs more suitable for tumor diagnosis and treatment, their natural properties and the interrelationships between these properties should be systematically and profoundly understood. The natural properties of AuNPs were discussed from two aspects: physical and chemical. Among the physical properties of AuNPs, localized surface plasmon resonance (LSPR), radioactivity and high X-ray absorption coefficient are widely used in the diagnosis and treatment of tumors. As an advantage over many other nanoparticles in chemicals, AuNPs can form stable chemical bonds with S-and N-containing groups. This allows AuNPs to attach to a wide variety of organic ligands or polymers with a specific function. These surface modifications endow AuNPs with outstanding biocompatibility, targeting and drug delivery capabilities. In this review, we systematically summarized the physicochemical properties of AuNPs and their intrinsic relationships. Then the latest research advancements and the developments of basic research and clinical trials using these properties are summarized. Further, the difficulties to be overcome and possible solutions in the process from basic laboratory research to clinical application are discussed. Finally, the possibility of applying the results to clinical trials was estimated. We hope to provide a reference for peer researchers to better utilize the excellent physicochemical properties of gold nanoparticles in oncotherapy.

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Section: Targetingmentioning

confidence: 99%

Section: Deliverymentioning

confidence: 99%

Section: Deliverymentioning

confidence: 99%

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The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment

Bai

Wang

Song

et al. 2020

IJMS

275

156

View full text Add to dashboard Cite

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“…The analysis results showed that the spatial-temporal distribution of GC-Au NPs in the sentinel lymph node was affected by the presence of metastases. This imaging method can successfully detect metastatic from nonmetastatic lymph nodes using Au NPs [ 108 ]. There was a study to visualize murine lymph vessels using PAI and Au NPs as a contrast agent, and the study showed great potential for it to be used to detect sentinel lymph nodes [ 109 ].…”

Section: Medical Imagingmentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

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“…Meanwhile, GC has been used to coat gold NPs (GC-AuNPs) as an imaging contrast agent for the US-guided photoacoustic (USPA) imaging of sentinel lymph node (SLN) metastases [15]. The USPA immunofunctional imaging successfully discriminated metastatic lymph nodes from non-metastatic ones [15], which can help physicians to detect micrometastases by SLN biopsy. GC-AuNPs were conjugated with 4-azidobenzoic acid (AzBA), yielding AzGC-AuNPs [16].…”

Section: Gc Derivatives For Imaging Applicationsmentioning

confidence: 99%

Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery

Lin

Jia

2019

Molecules

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Glycol chitosan (GC), a water-soluble chitosan derivative with hydrophilic ethylene glycol branches, has both hydrophobic segments for the encapsulation of various drugs and reactive functional groups for facile chemical modifications. Over the past two decades, a variety of molecules have been physically encapsulated within or chemically conjugated with GC and its derivatives to construct a wide range of functional biomaterials. This review summarizes the recent advances of GC-based materials in cell surface labeling, multimodal tumor imaging, and encapsulation and delivery of drugs (including chemotherapeutics, photosensitizers, nucleic acids, and antimicrobial agents) for combating cancers and microbial infections. Besides, different strategies for GC modifications are also highlighted with the aim to shed light on how to endow GC and its derivatives with desirable properties for therapeutic purposes. In addition, we discuss both the promises and challenges of the GC-derived biomaterials.

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Ultrasound-guided immunofunctional photoacoustic imaging for diagnosis of lymph node metastases

Abstract: A minimally invasive method to detect lymph node metastases using glycol-chitosan-coated gold nanoparticles and ultrasound-guided photoacoustic imaging.

Cited by 29 publications

References 63 publications

The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment

The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery

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