Ultrasound-Guided Implantation Techniques in Treatment of Prostate Cancer

Carter, Simon St. C.; Torp‐Pedersen, Søren; Holm, Hans Henrik

doi:10.1016/s0094-0143(21)01809-7

Cited by 14 publications

(1 citation statement)

References 18 publications

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“…Ultrasound guided prostate brachytherapy implants have been performed for almost two decades (Holm et al 1983). Needles preloaded with a train of iodine-125 seeds (Carter et al 1989) or palladium-103 seeds (Meigooni et al 1990) and spacers are introduced into the prostate with the help of a template and under ultrasound guidance, and then retracted while leaving the seeds in place permanently. A pre-implant treatment plan determines how many seeds each needle will deliver, and how the seeds are arranged within the needles, such that proper target coverage may be achieved.…”

Section: Introductionmentioning

confidence: 99%

The effect of seed orientation deviations on the quality of¹²⁵I prostate implants

Corbett¹,

Jezioranski²,

Crook³

et al. 2001

Phys. Med. Biol.

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We quantified the effect of seed orientation deviations on five prostate seed implant cases at our institution. While keeping their positions fixed, the iodine-125 seeds were assigned orientations sampled from a realistic probability distribution derived from the post-implant radiographs of ten patients. Dose distributions were calculated with both a model that explicitly includes anisotropy (TG43 anisotropy function) and a point source model (TG43 anisotropy factor). Orientation deviations had only a small influence on prostate dose-volume histograms: the 95% confidence intervals on the volumes receiving 100%, 150% and 200% dose were at most +/-0.8%, +/-1.1% and +/-0.6% of the prostate volume, respectively. The dose-volume histograms of anisotropic seed distributions were marginally better than those with isotropic point-source seeds. Anisotropy caused a displacement of cold spots (regions receiving <100% of the prescribed dose) in <1% of the prostate volume. Our results indicate no net benefit to prostate dosimetry in using more isotropic seeds. Furthermore, we propose a new 'weighted anisotropy function' to better account for the effects of anisotropy when seed orientation is unknown. Conceptually, the TG43 anisotropy factor described in AAPM TG43 averages the effect of anisotropy over all solid angles, with the implicit assumption that all seed orientations are equally probable. In prostate implants, however, seeds are preferentially oriented parallel to the needle axis. The proposed weighted anisotropy function incorporates this non-uniform probability.

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Section: Introductionmentioning

confidence: 99%

The effect of seed orientation deviations on the quality of¹²⁵I prostate implants

Corbett¹,

Jezioranski²,

Crook³

et al. 2001

Phys. Med. Biol.

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Analysis of iodine‐125 interstitial therapy in the treatment of localized carcinoma of the prostate

Gomella

Steinberg

Ellison

et al. 1991

Journal of Surgical Oncology

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Definitive treatment of localized carcinoma of the prostate has included radical surgery, external beam radiation therapy, and interstitial radiation therapy. The interstitial agent most commonly used is Iodine-125. Forty-eight patients were treated with interstitial radiation therapy using Iodine-125 implants with a median follow-up of 55 months. Forty-three percent of the evaluable patients had progressive disease with approximately 50% progressing at 5 years by Kaplan-Meier analysis. Overall actuarial survival in the group was 80% at 5 years. This and several other studies suggest that control of prostate cancer with Iodine-125 seeds may be suboptimal as compared with other treatment modalities, especially the radical retropubic prostatectomy. Analysis of treatment parameters is presented along with a discussion of the current status and future prospects for treatment of localized carcinoma of the prostate with interstitial radiation therapy.

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Contemporary Imaging of the Prostate

Oyen

1994

Benign Prostatic Hyperplasia

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Ultrasound-Guided Implantation Techniques in Treatment of Prostate Cancer

Cited by 14 publications

References 18 publications

The effect of seed orientation deviations on the quality of¹²⁵I prostate implants

The effect of seed orientation deviations on the quality of¹²⁵I prostate implants

Analysis of iodine‐125 interstitial therapy in the treatment of localized carcinoma of the prostate

Contemporary Imaging of the Prostate

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Ultrasound-Guided Implantation Techniques in Treatment of Prostate Cancer

Cited by 14 publications

References 18 publications

The effect of seed orientation deviations on the quality of125I prostate implants

The effect of seed orientation deviations on the quality of125I prostate implants

Analysis of iodine‐125 interstitial therapy in the treatment of localized carcinoma of the prostate

Contemporary Imaging of the Prostate

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Product

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The effect of seed orientation deviations on the quality of¹²⁵I prostate implants

The effect of seed orientation deviations on the quality of¹²⁵I prostate implants