Ultrasound-Guided Laser Ablation of Incidental Papillary Thyroid Microcarcinoma: A Potential Therapeutic Approach in Patients at Surgical Risk

Papini, Enrico; Guglielmi, Rinaldo; Gharib, Hossein; Misischi, Irene; Graziano, Filomena; Chianelli, Marco; Crescenzi, Anna; Bianchini, A.; Valle, D.; Bizzarri, Giancarlo

doi:10.1089/thy.2010.0447

Cited by 107 publications

(88 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 16G antenna used in the study was more invasive than the 17G needle used for RFA (22) and 21G needle for laser ablation (29). Nerve injury was the most serious complication in our study.…”

Section: A B C D E Fmentioning

confidence: 63%

Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies

Feng

Liang

Cheng

et al. 2012

European Journal of Endocrinology

124

125

View full text Add to dashboard Cite

Purpose: To obtain the treatment parameters of internally cooled microwave antenna and to evaluate the feasibility of ultrasound-guided percutaneous microwave ablation (MWA) for benign thyroid nodules. Materials and methods: MWAs were performed by microwave antenna (16G) in ex vivo porcine liver. The lesion diameters achieved in different groups (20, 25, and 30 W for 3, 5, 7, 10, and 12 min) were compared. The clinical study was approved by the ethics committee. Written informed consent was obtained from all patients. MWA was performed in 11 patients (male to female ratioZ1:10; mean age, 50G7 years) with 11 benign thyroid nodules. Ultrasound scan, laboratory data, and clinical symptoms were evaluated before and 1 day and 1, 3, 6, 9, and 12 months after the procedure. Results: In ex vivo study, the ablation lesion at 30 W 12 min tended to have appropriate scope and spherical shape. In clinical study, the follow-up periods ranged from 1 to 9 months. At the last followup, the largest diameter decreased from 2.9G1.0 (range, 1.6-4.1) to 1.9G0.7 (range, 0.4-3.0) cm (P!0.01), and the volume decreased from 5.30G4.88 (range, 0.89-14.81) to 2.40G2.06 (range, 0.02-6.35) ml (P!0.01). The volume reduction ratio was 45. 99G29.90 (range, 10.56-98.15) %. The cosmetic grading score was reduced from 3.20G0.79 to 2.30G0.95 (P!0.05). One patient experienced temporary nerve palsy and was recovered within 2 months after treatment. Conclusion: The internally cooled microwave antenna can yield ideal ablation lesions, and ultrasoundguided percutaneous MWA is a feasible technique for benign thyroid nodules.

show abstract

Section: A B C D E Fmentioning

confidence: 63%

Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies

Feng

Liang

Cheng

et al. 2012

European Journal of Endocrinology

124

125

View full text Add to dashboard Cite

show abstract

“…However, only one case of papillary thyroid microcarcinoma (PTMC) treated with LA has been reported in the literature to date. In this latter case, no histological demonstration of complete PTMC destruction has been provided (6).…”

Section: Introductionmentioning

confidence: 89%

Ultrasound-Guided Percutaneous Laser Ablation of Papillary Thyroid Microcarcinoma: A Feasibility Study on Three Cases with Pathological and Immunohistochemical Evaluation

Valcavi¹,

Piana²,

Bortolan³

et al. 2013

Thyroid

View full text Add to dashboard Cite

This study demonstrates that percutaneous LA is technically feasible for complete PTMC destruction. Now, LA may be useful in selected patients with PTMC, either when the surgeon or a patient refuses surgery, or when the patient is at high risk for an operation. LA may become a primary choice of treatment for PTMC only if future new knowledge would permit preoperative recognition of multifocality and lymph node metastasis.

show abstract

“…Although current pieces of scientific evidence and experts' opinions do not allow us to treat these lesions in a nonsurgical, conservative fashion [52,53], we can suppose that in the near future, US-guided techniques might play a role also in primary PTMC, when no multifocality or nodal metastasis was found, offering patients a less aggressive therapeutic option without reducing the clinical outcomes and the very high rate of disease-free survival.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement

Garberoglio

Aliberti

Appetecchia³

et al. 2015

J Ultrasound

Self Cite

120

140

View full text Add to dashboard Cite

Nodular thyroid disease is a very common finding in\ud clinical practice, discovered by ultrasound (US) in about\ud 50 % of the general population, with higher prevalence in\ud women and in the elderly [1–4].\ud Whereas therapeutic flowchart is quite established and\ud shared for malignant lesions, multiple options are now\ud available for patients presenting with benign thyroid nod-\ud ules, ranging from simple clinical and US follow-up to\ud thyroid surgery. The majority of thyroid nodules, benign by\ud fine-needle aspiration, are asymptomatic, stable, or slow-\ud growing over time and require no treatmen

show abstract

Ultrasound-Guided Laser Ablation of Incidental Papillary Thyroid Microcarcinoma: A Potential Therapeutic Approach in Patients at Surgical Risk

Cited by 107 publications

References 19 publications

Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies

Ultrasound-guided percutaneous microwave ablation of benign thyroid nodules: experimental and clinical studies

Ultrasound-Guided Percutaneous Laser Ablation of Papillary Thyroid Microcarcinoma: A Feasibility Study on Three Cases with Pathological and Immunohistochemical Evaluation

Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement

Contact Info

Product

Resources

About