Centipede bites are reported in many parts of tropical and subtropical countries, such as India. Centipede envenomation produces significant local symptoms, with pain being the most prominent symptom. The emergency department (ED) plays a crucial role in managing the victims through appropriate pain management and control of other local and systemic symptoms. Nonopioids and weak opioids, along with local measures, are often employed, but the intense pain is often refractory to these conventional techniques. Regional anesthesia has numerous benefits over these traditional measures, such as avoidance of polypharmacy and its consequent systemic adverse effects, excellent quality of pain control, and decreased need or avoidance of hospital admission. The applications of regional anesthesia have recently increased tremendously in the ED but are unreported for the management related to centipede bites. We report a case of centipede bite in which conventional analgesics did not help, and the pain was successfully managed by low-volume selective sensory peripheral nerve block.