Ultrasound-guided thermal ablation for papillary thyroid microcarcinoma: a multicenter retrospective study

Cao, Xiaojing; Yu, Ming; Ya-lin, Zhu; Lü, Qing; Cong, Zhi-Bin; Yan, Guoquan; Liu, Juan; Wang, Hongling; Li, Geng; Guo, Jun; Hao, Ying; Wang, Zhonghua; Wang, Xue; He, Jiacai; Shataer, Aini; Liu, Xiaofang; Zhao, Zhenlong; Wei, Ying; Peng, Li-Li; Li, Yan; Wang, Shurong; Che, Ying

doi:10.1080/02656736.2021.1936218

Cited by 26 publications

(10 citation statements)

References 27 publications

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“…The 2015 ATA guidelines suggest that patients with low risk PTMCs can also be actively monitored (15); however, some patients are unable to undergo long-term follow-up because of anxiety about the disease, and in these cases, ablation of PTMC is a compromise between surgery and observation. A multicenter PTMC ablation study conducted in China that included 11 centers and 725 patients (21) showed a significant reduction in tumor size at 6 months after ablation compared with that before ablation. On ultrasound, 515 (71.0%) PTMCs disappeared completely.…”

Section: Review Thermal Ablation Study Of Papillary Thyroid Microcarc...mentioning

confidence: 99%

“…In addition, the rich blood supply to the thyroid gland can lead to transient bleeding at the end of the ablation, although this can be relieved with compression. Finally, a small number of patients experience complications such as altered thyroid function (24,27,49,50,60,77) and cough (21,36,45) after thermal ablation, which normally resolve during the postoperative period.…”

Section: Complicationsmentioning

confidence: 99%

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Research Review of Thermal Ablation in the Treatment of Papillary Thyroid Carcinoma

Chen

Tian

et al. 2022

Front. Oncol.

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BackgroundMinimally invasive treatment of thyroid tumors has become increasingly common, but has mainly focused on benign thyroid tumors, whereas thermal ablation of thyroid cancer remains controversial. Clinical studies analyzing the efficacy of thermal ablation of papillary thyroid carcinoma (PTC) have been conducted in several countries to verify its safety. Here, we screened and reviewed recent studies on the efficacy and safety of thermal ablation of PTC as well as psychological assessment, patient prognosis, recurrence, and factors affecting ablation.SummaryThe most significant controversy surrounding ablative treatment of PTC centers on its effectiveness and safety, and >40 studies have been conducted to address this issue. The studies include papillary thyroid microcarcinoma (PTMC) and non-PTMC, single PTC and multiple PTC, and controlled studies of ablative therapy and surgical treatment. In general, ablation techniques can be carefully performed and promoted under certain conditions and with active follow-up of postoperative patients. Ablation is a promising alternative treatment especially in patients who are inoperable.ConclusionsClinical studies on PTC ablation have provided new perspectives on local treatment. However, because PTC grows very slowly, it is an indolent tumor; therefore, studies with larger sample sizes and extended post-procedure follow-ups are necessary to confirm the investigators’ hypotheses.

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Section: Review Thermal Ablation Study Of Papillary Thyroid Microcarc...mentioning

confidence: 99%

Section: Complicationsmentioning

confidence: 99%

Research Review of Thermal Ablation in the Treatment of Papillary Thyroid Carcinoma

Chen

Tian

et al. 2022

Front. Oncol.

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“…25 Currently, treatment regimens for PTMC range from thyroidectomy, AS, and US-guided RFA. 5,8,15 Herein, the current study sought to evaluate the effects of US-guided RFA on PTMC and influencing factors, and the obtained findings revealed that US-guided RFA exhibits better efficacy, safety, and postoperative recovery and lower recurrence risk for PTMC treatment.…”

Section: Discussionmentioning

confidence: 99%

“…9 However, AS treatment is not suitable for all PTMC cases and some physicians hesitate to adopt the management policy in daily clinical practice. 10 The last decade has also witnessed the surge and adoption of US-guided ablation techniques such as laser ablation, 11 microwave ablation, [12][13][14] or radiofrequency ablation (RFA) 15 for successfully treating patients with benign thyroid nodules, PTMC, or metastatic lymph nodes at risk of surgery. Additionally, USguided RFA treatment is highly safe and effective for PTMC, and it can serve as a minimally invasive therapy for patients with PTMC who refuse AS or surgical treatment.…”

mentioning

confidence: 99%

Analysis of Therapeutic Effect and Influencing Factors of Ultrasound‐Guided Radiofrequency Ablation in the Treatment of Papillary Thyroid Microcarcinoma

Zeng

Zou

Chen

et al. 2023

J of Ultrasound Medicine

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Objectives The current study sought to explore the effects of ultrasound (US)‐guided radiofrequency ablation (RFA) on papillary thyroid microcarcinoma (PTMC) and influencing factors. Methods PTMC patients were assigned to observation (US‐guided RFA) and control (surgical operation) groups. A series of operation‐related indexes (operation time, intraoperative bleeding, wound closure time, hospital stay, and expenses), visual analogue scale score, lesion size, and thyroid function‐related indexes (thyroid‐stimulating hormone [TSH], free triiodothyronine*** [FT3], free thyroxine [FT4]), inflammatory factors, and thyroglobulin antibody (TgAb) were assessed and compared. After a 6‐month follow‐up period, the complications and recurrence were recorded, in addition to analyses of postoperative recurrence cumulative incidence and evaluation of recurrence risk factors. Results Operation‐related indexes of the observation group were relatively decreased compared with the control group. In addition, the lesion volume in the observation group was lower compared to that in the control group at the 6th month after operation, whereas the volume reduction rate was higher. There were no significant differences in regard to thyroid function‐related indexes in the observation group before/after operation. After operation, serum TSH levels and inflammatory factors, and TgAb levels were all diminished, while the FT3 and FT4 levels were both elevated in the observation group relative to the control group, and postoperative recurrence cumulative incidence was lower in the observation group. TSH and TgAb were established as the independent risk factors for recurrence after RFA in PTMC patients. Conclusions Our findings highlighted that US‐guided RFA exhibits better efficacy, safety, and postoperative recovery and lower recurrence risk for PTMC.

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“…Microwave ablation (MWA) has been widely used in the treatment of benign thyroid nodules [ 5 ] and papillary thyroid cancer (PTC) [ 6 , 7 ]. Studies have demonstrated that MWA can preserve thyroid function in patients even with bilateral thyroid nodule ablation [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules

Zhao

Wei

Liu

et al. 2022

International Journal of Endocrinology

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Purpose. Microwave ablation (MWA) is a minimally invasive method for the thermal ablation of benign thyroid nodules and papillary thyroid cancer (PTC) and has shown promising results. The aim of this study was to investigate the impact of MWA on thyroid antibodies and associated influencing factors. Materials and Methods. A total of 119 patients, including 69 with benign thyroid nodules and 50 with PTC, underwent MWA between June 2019 and June 2021. The serum levels of (free) triiodothyronine, (free) thyroxine, thyrotropin, and antibodies against Tg (TGAb), thyrotropin receptors (TRAb), and thyroid peroxidase (TPOAb) were measured during the follow up. Results. One month after ablation, three patients (4.3%) in the benign group had hypothyroidism, and one (1.4%) had hyperthyroidism. Four patients (5.8%) had subclinical hypothyroidism, and two (2.9%) had subclinical hyperthyroidism. Among the PTC patients, two (4%) had hypothyroidism, and one (2%) had hyperthyroidism. Two patients (4%) had subclinical hypothyroidism, and one (2%) had subclinical hyperthyroidism. In the benign group, among patients with normal preablation antibodies, the postablation TGAb abnormal rate was 12.7%, the TPOAb level was 4.8%, and the TRAb level was 0%. Among PTC patients, the postablation TGAb abnormal rate was 11.4%, the TPOAb level was 8.7%, and the TRAb level was 4.0%. The cutoff value of preablation TGAb for predicting postoperative antibody abnormalities was 19.0 IU/mL, while that of TPOAb was 11.4 IU/mL. Conclusions. MWA of thyroid nodules had little influence on thyroid function and antibodies. Elevations in TGAb, TPOAb, and TRAb beyond the normal ranges after MWA may be related to high preablation levels of TGAb and TPOAb.

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Ultrasound-guided thermal ablation for papillary thyroid microcarcinoma: a multicenter retrospective study

Cited by 26 publications

References 27 publications

Research Review of Thermal Ablation in the Treatment of Papillary Thyroid Carcinoma

Research Review of Thermal Ablation in the Treatment of Papillary Thyroid Carcinoma

Analysis of Therapeutic Effect and Influencing Factors of Ultrasound‐Guided Radiofrequency Ablation in the Treatment of Papillary Thyroid Microcarcinoma

Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules

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