Catheter directed electrophysiology (EP) studies and ablations have emerged as common and widely accepted therapies for various types of arrhythmia. The femoral vasculatures serve as access sites, in the majority of instances. Despite the need for multiple venous sheath placement within a single vein, early reporting of vascular related bleeding complications was naught [1,2]. With increasing frequency of complex procedures such as pulmonary vein antral isolation (PVAI) performed with maintenance of peri-procedural anticoagulation and those necessitating arterial access, vascular complication rates rose to 1-2% [3,4]. In spite of advancements in catheterbased EP procedures in the past two decades leading to improved efficacy and overall safety, the incidence of vascular complication has remained unchanged [5,6].Vascular complications directly impact patient morbidity and increase health care costs. They are usually the consequence of inadvertent arterial puncture and cannulation, particularly when using large diameter sheaths and/or with aggressive anticoagulation. Baum et al. described overlap of the femoral artery (CFA) and common femoral vein (CFV) along some portion of their course in two-thirds of patients studied, predisposing to simultaneous puncture of the overlapping artery during intended venous cannulation and resulting in arteriovenous fistula formation. High bifurcation of the CFA at the level of the mid femoral head was also found to be not uncommon [7]. Such anatomic variation cannot be appreciated without real-time imaging, and increases risk for pseudoaneurysm formation due to accidental puncture of the superficial femoral artery [8].Real-time ultrasound guidance (US) allows direct visualization of vascular structures, and its use has been shown to significantly improve procedural success and/or reduce complications. US has been endorsed in Practice Guidelines put forth by various societies [9][10][11]. Yet in spite of wide acceptance in the medical and surgical communities, US guidance has not been routinely utilized in all EP labs. The first reported comparative study was from our institution and included 3510 patients undergoing PVAI, requiring multiple femoral venous accesses [12]. US guided femoral venous access reduced total and major vascular complications by 3-fold and 7-fold. This result was even more significant, given that 73% of patients undergoing US guided venipuncture had an INR ≥1.9 on the day of the procedure. This was in comparison with the non-US guidance group, in whom only 9% of patients had an INR ≥1.9 on the day of the procedure. This finding is a testament to the protective effect of US, apparent even in the cohort at greater risk for bleeding. Similar improved outcomes have been corroborated by publications from three other institutions, forming a robust experience that confirms the effectiveness of US in reducing vascular complications during EP procedures [13][14][15]. A summary of these four publications by Sobolev et al., including over 4000 subjects, showed a 60% re...