Ultrasound-Guided Versus Anatomic Landmark–Guided Steroid Injection of the Subacromial Bursa in the Management of Subacromial Impingement: A Systematic Review of Randomised Control Studies

Ayekoloye, Charles; Nwangwu, Osondu

doi:10.1007/s43465-020-00148-w

Cited by 8 publications

(8 citation statements)

References 35 publications

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“…Since the solution to gel transition of our formulation occurs within a physiologically relevant temperature window, we sought to prove that we could successfully noninvasively inject it under ultrasound guidance, a common imaging modality. In humans, ultrasound-guided injections have been explored extensively and injections of agents including steroids are routinely performed. − Even in the small mouse hindlimb, we were able to visualize the sciatic nerve and successfully inject 4-AP thermogel onto the injury site. It remains to be seen whether ultrasound-guided injection of our agent in humans is feasible.…”

Section: Discussionmentioning

confidence: 99%

(4-Aminopyridine)–PLGA–PEG as a Novel Thermosensitive and Locally Injectable Treatment for Acute Peripheral Nerve Injury

Manto

Govindappa

Parisi

et al. 2021

ACS Appl. Bio Mater.

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Traumatic peripheral nerve injury (TPNI) represents a major medical problem that results in loss of motor and sensory function, and in severe cases, limb paralysis and amputation. To date, there are no effective treatments beyond surgery in selective cases. In repurposing studies, we found that daily systemic administration of the FDA-approved drug 4aminopyridine (4-AP) enhanced functional recovery after acute peripheral nerve injury. This study was aimed at constructing a novel local delivery system of 4-AP using thermogelling polymers. We optimized a thermosensitive (4-AP)−poly(lactide-co-glycolide)−b-poly(ethylene glycol)−b-poly(lactide-co-glycolide) (PLGA−PEG−PLGA) block copolymer formulation. (4-AP)− PLGA−PEG exhibited controlled release of 4-AP both in vitro and in vivo for approximately 3 weeks, with clinically relevant safe serum levels in animals. Rheological investigation showed that (4-AP)−PLGA−PEG underwent a solution to gel transition at 32 °C, a physiologically relevant temperature, allowing us to administer it to an injured limb while subsequently forming an in situ gel. A single local administration of (4-AP)−PLGA−PEG remarkably enhanced motor and sensory functional recovery on post-sciatic nerve crush injury days 1, 3, 7, 14, and 21. Moreover, immunohistochemical studies of injured nerves treated with (4-AP)-PLGA-PEG demonstrated an increased expression of neurofilament heavy chain (NF-H) and myelin protein zero (MPZ) proteins, two major markers of nerve regeneration. These findings demonstrate that (4-AP)−PLGA−PEG may be a promising long-acting local therapeutic agent in TPNI, for which no pharmacologic treatment exists.

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Section: Discussionmentioning

confidence: 99%

(4-Aminopyridine)–PLGA–PEG as a Novel Thermosensitive and Locally Injectable Treatment for Acute Peripheral Nerve Injury

Manto

Govindappa

Parisi

et al. 2021

ACS Appl. Bio Mater.

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“…In contrast, a recent Cochrane review and another systematic review did not detect improved efficacy or advantages of USG corticosteroid injection for the management of SIS 19,23 . Bloom et al 19 included patients with various pathologies for shoulder pain (one of which was SIS), whereas Ayekoloye et al 23 included patients with SIS under the injection of the subacromial bursa only.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, a recent Cochrane review and another systematic review did not detect improved efficacy or advantages of USG corticosteroid injection for the management of SIS. 19 , 23 Bloom et al 19 included patients with various pathologies for shoulder pain (one of which was SIS), whereas Ayekoloye et al 23 included patients with SIS under the injection of the subacromial bursa only. However, these previous systematic reviews, 19 , 23 which obtained negative results, included only 4–5 studies involved 234–290 patients with different causes of shoulder pain, whereas our study included 12 trials involving 891 participants with SIS.…”

Section: Discussionmentioning

confidence: 99%

“… 19 , 23 Bloom et al 19 included patients with various pathologies for shoulder pain (one of which was SIS), whereas Ayekoloye et al 23 included patients with SIS under the injection of the subacromial bursa only. However, these previous systematic reviews, 19 , 23 which obtained negative results, included only 4–5 studies involved 234–290 patients with different causes of shoulder pain, whereas our study included 12 trials involving 891 participants with SIS. In addition, participants included in previous studies were in the chronic stage of SIS, which is less responsive to corticosteroid injections reported, 42 and these patients received additional treatments with the corticosteroid injection, which may have influenced the outcome measures.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies 15,16 indicated that USG injections for SIS resulted in significant improvements in pain relief and physical function compared with ALG injections, whereas others 17,18 reported no positive results. The results from previous systematic reviews were contradictory and previous studies were limited by small sample sizes, ambiguous definitions of SIS, and increased costs were raised to justify the advantages of using USG injections for SIS 19–23 . Therefore, to address these concerns, a systematic review and meta-analysis were performed to summarize and update the current evidence on the efficacy and safety of applying USG versus ALG corticosteroid injection in the management of SIS.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Ultrasound-Guided Versus Anatomic Landmark–Guided Corticosteroid Injection on Pain, Physical Function, and Safety in Patients With Subacromial Impingement Syndrome

Deng

Zhu

et al. 2021

Am J Phys Med Rehabil

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The aim of the study was to compare the efficacy and safety of ultrasound-guided versus anatomic landmark-guided corticosteroid injection for the treatment of subacromial impingement syndrome. Design: PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, Scopus, ClinicalTrials.gov, CBM, CNKI, and Wanfang databases were searched from inception to August 15, 2021, for randomized controlled trials comparing ultrasound-guided versus anatomic landmark-guided injections of corticosteroids for the treatment of subacromial impingement syndrome. Results: Twelve randomized controlled trials with 891 patients were included in this study; 454 patients received ultrasound-guided injections and 437 received anatomic landmark-guided injections. Pooled results showed that ultrasound-guided injection was more beneficial for pain relief (10 trials; mean difference = −0.58; 95% confidence interval = −1.05 to −0.10; P = 0.017) and functional improvement (11 trials; standard mean difference = −0.84; 95% confidence interval = −1.41 to −0.27; P = 0.004). There was no significant difference in shoulder range of motion. In the subgroup analysis, there was a significant difference in pain relief and functional improvement at 6-8 wks and with methylprednisolone. Conclusions: Ultrasound-guided injection of corticosteroids is potentially superior to anatomic landmark-guided injection in improving the clinical symptoms of subacromial impingement syndrome; however, these findings should be interpreted with some caution as the quality of evidence was rated as moderate to very low.

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Actualité des traitements des tendinopathies dégénératives de la coiffe des rotateurs de l'épaule

Jacob¹,

Beaudreuil²

2022

l'Actualité Rhumatologique 2022

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Ultrasound-Guided Versus Anatomic Landmark–Guided Steroid Injection of the Subacromial Bursa in the Management of Subacromial Impingement: A Systematic Review of Randomised Control Studies

Cited by 8 publications

References 35 publications

(4-Aminopyridine)–PLGA–PEG as a Novel Thermosensitive and Locally Injectable Treatment for Acute Peripheral Nerve Injury

(4-Aminopyridine)–PLGA–PEG as a Novel Thermosensitive and Locally Injectable Treatment for Acute Peripheral Nerve Injury

Effectiveness of Ultrasound-Guided Versus Anatomic Landmark–Guided Corticosteroid Injection on Pain, Physical Function, and Safety in Patients With Subacromial Impingement Syndrome

Actualité des traitements des tendinopathies dégénératives de la coiffe des rotateurs de l'épaule

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