Ultrasound, histopathological, and genetic features of uveal melanoma in a Mexican-Mestizo population

Delgado, Stefanie; Reyes, Angel Espinosa; Ríos, L.; Dueñas‐González, Alfonso; Taja‐Chayeb, Lucía; Adame, Eduardo Moragrega

doi:10.1016/j.oftale.2017.09.005

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…One study suggested decreased mortality in Hispanic compared with white patients (odds ratio [OR], 0.6), while another study found no statistically significant difference in metastasis, survival, or mortality between ethnicities . Histopathologic studies have reported that the clinical and genetic course of nonwhite patients with UM may be different than in white patients, with Asian Indian individuals presenting younger, Mexican-Mestizo patients showing a previously unreported polymorphism, and Hispanic patients presenting with unique symptoms and broader-based tumors . Various case reports have shown that UM occurs in all races …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014

et al. 2020

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Identifying disparities in uveal melanoma (UM) treatment patterns and survival across racial, ethnic, and socioeconomic (SES) groups reveals possible inequities in ophthalmologic health care.OBJECTIVE To examine the association of race, ethnicity, and SES with UM treatment and survival. DESIGN, SETTING, AND PARTICIPANTSA retrospective cohort analysis of 28% of the US population using the Surveillance, Epidemiology, and End Results (SEER) 18 registries from January 1, 2004, to December 31, 2014, was conducted. Data analysis was performed from April to July 2018. SEER identified 4475 individuals using International Classification of Diseases for Oncology, Third Edition site and morphology codes.EXPOSURES Race, ethnicity, and SES estimated by tertile using Yost Index composite scores.MAIN OUTCOMES AND MEASURES Treatment odds ratios (ORs), 1-year and 5-year survival estimates, mortality hazard ratios (HRs), and Kaplan-Meier survival curves. Hypothesis was formulated before data collection.RESULTS Multivariate analyses of 4475 individuals (2315 [51.7%] men; non-Hispanic white, 4130 [92.3%]; nonwhite, 345 [7.7%]) showed that patients who were nonwhite (OR, 1.45; 95% CI, 1.12-1.88) and socioeconomically disadvantaged (lower SES: OR, 2.21; 95% CI, 1.82-2.68; middle SES: OR, 1.86; 95% CI, 1.56-2.21) were more likely to receive primary enucleation. No interactions were observed between race/ethnicity, SES, and stage at diagnosis. From 2004 to 2014, rates of primary enucleation decreased across all racial/ethnic and SES groups, but disparities persisted. Socioeconomically disadvantaged patients had lower 5-year all-cause survival rates (lower SES: 69.2%; middle SES: 68.1%; and upper SES: 73.8%), although disease-specific survival did not vary significantly by racial/ethnic or SES strata. Mortality risk was associated with older age at diagnosis

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Section: Introductionmentioning

confidence: 99%

Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014

et al. 2020

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“…These results indicate that patient with choroidal melanoma in Brazil take more time to get specialized care with an ocular oncologist which may reflect the low access of the population to eye health care. Similarly, a review of cases in Mexico found mean height of 10.9 mm and LBD of 13.5 mm also explained by the lack of access of the population to specialized eye care centers, a pattern that might be repeated in other countries from Latina America, reinforcing the health inequalities across the globe [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Choroidal melanoma tumor profile and treatment pattern for newly diagnosed patients at a reference public hospital in Sao Paulo, Brazil

et al. 2022

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Background Choroid, ciliary body, and iris melanomas are often grouped as uveal melanoma, the most common intraocular primary malignancy. The purpose of the current study was to analyze the tumor profile of newly diagnosed cases of choroidal melanoma at a reference center in Sao Paulo, Brazil, and to investigate the frequency of eyes treated by enucleation that could have been treated with brachytherapy if available in the service. Methods Medical records of patients referred to our service with initial diagnostic hypothesis of choroidal melanoma from July 2014 to June 2020 were analysed on demographics, diagnosis confirmation, tumor measurement by ultrasonography and established treatment. Data were evaluated on clinical and demographic characteristics as age, sex, affected eye, ultrasound parameters, and treatment management of patients with clinically diagnosed choroidal melanoma. Among the patients submitted to enucleation, we investigated how many could have been selected to receive brachytherapy. Results From the 102 patients referred with the choroidal melanoma diagnosis hypothesis, 70 (68.62%) were confirmed. Mean measurements from the tumors in millimetres were: 9.19 ± 3.69 at height and 12.97 ± 3.09 by 13.30 ± 3.30 at basal. A total of 48 cases (68.57%) were enucleated, 8 (11.43%) were treated by brachytherapy in a different service, and 14 patients (20.00%) returned for enucleation at their original referral center. Out of the 48 patients enucleated, 26 (54.17%) could have been selected to brachytherapy treatment. Conclusions The results indicate a late diagnosis of choroidal melanoma cases referred to our service. Most enucleated cases could have been treated with brachytherapy if it was broadly available at the national public health insurance. Further public health political efforts should focus on early diagnosis and better quality of life post-treatment for oncologic patients.

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Ultrasound, histopathological, and genetic features of uveal melanoma in a Mexican-Mestizo population

Cited by 2 publications

References 12 publications

Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014

Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014

Choroidal melanoma tumor profile and treatment pattern for newly diagnosed patients at a reference public hospital in Sao Paulo, Brazil

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