Ultrasound Imaging Modalities

Mischi, Massimo; Rognin, N.; Averkiou, Michalakis A.

doi:10.1016/b978-0-444-53632-7.00217-3

Cited by 9 publications

(6 citation statements)

References 111 publications

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“…The attenuation coefficient (a) is a frequencydependent parameter. Here, a was measured at seven (1:1:6 MHz, and 3.5 MHz) different frequencies according to (Mischi et al, 2014):…”

Section: Acoustic Measurementmentioning

confidence: 99%

“…where f is the frequency of the transmitted signal; A s and A w are the amplitudes of the frequency magnitude spectrum of the received signal in the presence of the sample and in water, respectively, and T is the transmission coefficient of the waves propagating through the front and rear surfaces of the sample, calculated as (Mischi et al, 2014):…”

Section: Acoustic Measurementmentioning

confidence: 99%

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Acoustic characterization of tissue-mimicking materials for ultrasound perfusion imaging research

Chen

Pollet

Panfilova

et al. 2022

Ultrasound in Medicine & Biology

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Materials with well-characterized acoustic properties are of great interest for the development of tissue-mimicking phantoms with designed (micro)vasculature networks. These represent a useful means for controlled in-vitro experiments to validate perfusion imaging methods such as Doppler and contrast-enhanced ultrasound (CEUS) imaging. In this work, acoustic properties of seven tissue-mimicking phantom materials at different concentrations of their compounds and five phantom case materials are characterized and compared at room temperature. The goal of this research is to determine the most suitable phantom and case material for ultrasound perfusion imaging experiments. The measurements show a wide range in speed of sound varying from 1057 to 1616 m/s, acoustic impedance varying from 1.09 to 1.71 £ 10 6 kg/m 2 s, and attenuation coefficients varying from 0.1 to 22.18 dB/cm at frequencies varying from 1 MHz to 6 MHz for different phantom materials. The nonlinearity parameter B/A varies from 6.1 to 12.3 for most phantom materials. This work also reports the speed of sound, acoustic impedance and attenuation coefficient for case materials. According to our results, polyacrylamide (PAA) and polymethylpentene (TPX) are the optimal materials for phantoms and their cases, respectively. To demonstrate the performance of the optimal materials, we performed power Doppler ultrasound imaging of a perfusable phantom, and CEUS imaging of that phantom and a perfusion system. The obtained results can assist researchers in the selection of the most suited materials for in-vitro studies with ultrasound imaging.

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“…The attenuation coefficient (a) is a frequencydependent parameter. Here, a was measured at seven (1:1:6 MHz, and 3.5 MHz) different frequencies according to (Mischi et al, 2014):…”

Section: Acoustic Measurementmentioning

confidence: 99%

Section: Acoustic Measurementmentioning

confidence: 99%

Acoustic characterization of tissue-mimicking materials for ultrasound perfusion imaging research

Chen

Pollet

Panfilova

et al. 2022

Ultrasound in Medicine & Biology

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“…However, in the small driving pressure amplitude regime, the bubble behaves as a forced damped linear oscillator [56]. The radial motion of free bubbles can also be characterized in terms of variations in the liquid enthalpy, as described by the Gilmore equation [58], [59].…”

Section: Pharmacokinetic Modeling Of Contrast Agents For Quantitamentioning

confidence: 99%

“…and related the parameter A to the blood volume, and β to the blood velocity [58]. Blood flow is then represented by their product.…”

Section: Modelmentioning

confidence: 99%

Mathematical Models of Contrast Transport Kinetics for Cancer Diagnostic Imaging: A Review

Turco

Wijkstra

Mischi

2016

IEEE Rev. Biomed. Eng.

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Angiogenesis plays a fundamental role in cancer growth and the formation of metastasis. Novel cancer therapies aimed at inhibiting angiogenic processes and/or disrupting angiogenic tumor vasculature are currently being developed and clinically tested. The need for earlier and improved cancer diagnosis, and for early evaluation and monitoring of therapeutic response to angiogenic treatment, have led to the development of several imaging methods for in vivo noninvasive assessment of angiogenesis. The combination of dynamic contrast-enhanced imaging with mathematical modeling of the contrast agent kinetics enables quantitative assessment of the structural and functional changes in the microvasculature that are associated with tumor angiogenesis. In this paper, we review quantitative imaging of angiogenesis with dynamic contrast-enhanced magnetic resonance imaging, computed tomography, and ultrasound.

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“…We also considered testing the relative nonlinearity coefficient B/ A. This sensitive biomechanical property has long been utilized in ultrasonic imaging of blood and biomolecular imaging [26][27][28], as well as for quantitative non-destructive investigations [29]. The sequential variations of the three parameters are compared to their values at the beginning of the storage period, when the sample is fresh and ideal for transfusion and, therefore, can be regarded as the reference sample.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic testing of the biomechanical properties of donation blood

Mohamed

Pomarède

Mangin

et al. 2023

Biomed. Phys. Eng. Express

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Background: Donated blood is routinely preserved for about six weeks. After that, a considerable amount of unused blood is discarded for safety. We carried out sequential measurements of the ultrasonic parameters (Velocity of propagation of ultrasound, its attenuation, and relative nonlinearity coefficient B/A) for red blood cell (RBCs) bags in their physiological preserving conditions in the blood bank to investigate the gradual deteriorations in the biomechanical properties of RBCs. Materials and Methods: We discuss our primary findings, which indicate the applicability of ultrasound techniques as a quantitative quick, non-invasive routine check for the validity of sealed blood bags. The technique can be applied during and beyond the regular preservation period, thus enabling deciding for each bag to either further preserve or withdraw. Results and Discussion: Considerable increases in the velocity of propagation (V = 966 m/s) and ultrasound attenuation ( = 0.81dB/Cm) were detected to take place during the preservation time. Likewise, the relative nonlinearity coefficient showed a generally rising trend during the preservation period ( (B/A) = 0.0129). At the same time, a distinctive feature characteristic of a specific blood group type is realized in all cases.Due to the complex stress-strain relations and their reflection on the hydrodynamics and flow rate of non-Newtonian fluids, the increased viscosity of long-preserved blood may justify the known post-transfusion flow complications.

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Ultrasound Imaging Modalities

Cited by 9 publications

References 111 publications

Acoustic characterization of tissue-mimicking materials for ultrasound perfusion imaging research

Acoustic characterization of tissue-mimicking materials for ultrasound perfusion imaging research

Mathematical Models of Contrast Transport Kinetics for Cancer Diagnostic Imaging: A Review

Ultrasonic testing of the biomechanical properties of donation blood

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