Ultrasound in gout: A useful tool for following urate-lowering therapy

Ottaviani, Sébastien; Gill, Ghislaine; Aubrun, Aurore; Palazzo, Élisabeth; Meyer, Olivier; Dieudé, Philippe

doi:10.1016/j.jbspin.2014.03.011

Cited by 59 publications

(44 citation statements)

References 12 publications

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“…The total number of intraarticular T, periarticular T, total T, total DC, and total E found per patient on ultrasound ranged from 0-26, 0-4, 0-30, ficial margin of the articular hyaline cartilage, visible independent of the angle of insonation [6,9,10,15,18]; Erosion was defined as an intra-and /or extra-articular discontinuity of the bone surface (visible in two perpendicular planes) [15] The size of T was measured as the area of nodulus, considered to be US tophus, calculated by continuous tracing around the outline of the nodulus and calculating the area enclosed within the outline, measured using the integrated software in the US machine [19] (figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…The sensitivity and specificity of intraarticular US T, DC, and erosion according controls was estimated to be 85% and 83% (p<0, 0001), 87% and 86% (p<0, 0001), 63% and 70% (p=0,003), respectively. To eliminate the potential impact of hypouricemic treatment to the sensitivity of US [9,10], some statistical analysis in this study was done excluding patients treated with hypouricemic drugs. Only patients capable to recall the sites of gout attacks were selected for concordance analysis between the clinical joint involvement and US signs of urate deposition.…”

Section: Selection Of Patientsmentioning

confidence: 99%

“…High-resolution ultrasound (US) was shown to be more sensitive than conventional radiography in revealing joint damage -joint erosions -in gout [8]. US might be a tool for measuring the response to therapy in gout [9,10]. Relying on that, gout experts at the OMERACT 9 gout workshop stated that the number of gout attacks, the physical measurement of subcutaneous tophi (T), in combination with US assessment of intraarticular T may contribute to a definition of remission in patients with gout [11].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Clinical Symptoms and Ultrasonographic Signs in Gout

2017

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SummaryFor the first time, the new ACR/EULAR gout classification criteria incorporate ultrasound (US) evidence of double contour sign (DC), an articular cartilage abnormality related to the deposition of crystals on the surface of the hyaline cartilage, as a sign specific to gout. US recently has been used as an objective diagnostic tool for detecting urate deposition (tophus (T), DC) or joint damage (erosion) in gout. Objective: Our aim was to investigate the relationship between clinical gout activity and load of US changes, also to examine the concordance between patient reported joint attack (PRGA) and ultrasonographic intraarticular changes. Methods: Sixty monosodium-urate-crystal-confirmed gout patients and 36 healthy controls were prospectively included in one centre. The relationship between clinical symptoms and ultrasonographic gout-related changes investigating 36 joints and 4 tendons (m. triceps and patellar) was evaluated using Spearman's correlation and agreement analysis (kappa coefficient). Results: moderate, positive correlation was observed between the number of subcutaneous tophi and total US tophus area (rs=0,628), total number of DC (rs=0,612), and erosions (rs=0,526), all p<0, 0001, found per patient on US. Gout attacks and disease duration significantly positively correlated with the load of all investigated US changes (p<0, 01).

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Section: Resultsmentioning

confidence: 99%

Section: Selection Of Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Clinical Symptoms and Ultrasonographic Signs in Gout

2017

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“…In terms of responsiveness, recently Ottavianiet al [56] developed a new study to determine the ability of US to show decrease or disappearance of urate deposits in gouty patients requiring urate-lowering therapy (ULT). They studied 16 male patients.…”

Section: Discussionmentioning

confidence: 99%

Musculoskeletal ultrasonography in gout

et al. 2015

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Gout is a frequent inflammatory disease induced by the deposition of monosodium urate crystals in joints and extraarticular tissues. The natural history of the disease includes four different phases: asymptomatic hyperuricemia, acute attacks, intercritical phase, and chronic tophaceous gout. Imaging techniques have several applications in the diagnosis, clinical monitoring and management of the disease but, particularly, musculoskeletal ultrasound is able to detect a wide set of abnormalities in gout. This review reports the most relevant findings detectable by ultrasound and the current available data in the literature regarding the role of musculoskeletal ultrasound in gout.

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“…Un monitoring échographique des dépôts uratiques permet de visualiser la dissolution des dépôts uratiques [26][27][28]. Elle pourrait donc aider au suivi thérapeutique des patients goutteux.…”

Section: Suivi Thérapeutique Et éChographieunclassified

Échographie dans les arthropathies microcristallines

Ottaviani

2015

Revue du Rhumatisme Monographies

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Ultrasound in gout: A useful tool for following urate-lowering therapy

Cited by 59 publications

References 12 publications

The Relationship Between Clinical Symptoms and Ultrasonographic Signs in Gout

The Relationship Between Clinical Symptoms and Ultrasonographic Signs in Gout

Musculoskeletal ultrasonography in gout

Échographie dans les arthropathies microcristallines

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