Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug

Ling, Liying; Zhu, Lei; Li, Yibao; Liu, Chunhua; Cheng, Linxiu

doi:10.3389/fbioe.2021.703582

Cited by 7 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The three-dimensional (3-D) network-like morphology of these xerogels was observed under a scanning electron microscope (SEM). − The xerogel of MCH appeared as a 3-D cross-linked network-like cage structure, and toluene xerogel came out as regularly arranged 3-D clusters (Figure S10).…”

Section: Results and Discussionmentioning

confidence: 99%

Organogels Fabricated from Self-Assembled Nanotubes Containing Core Substituted Perylene Diimide Derivative

Moharana

Santosh

2022

ACS Omega

View full text Add to dashboard Cite

Perylene-based organogels are well-known for their applications as sensors and optoelectronic materials. Among them, core-substituted perylene diimide-based organogels are rarely explored. Herein, the hierarchical self-assembly mechanism of a newly synthesized, amide-linked core-substituted perylene diimide derivative, which formed organogels in organic solvents like toluene and methyl cyclohexane (MCH), is discussed. These organogels are composed of one-dimensional molecular aggregates like nanofibers and nanotubes. Organogels composed of nanofibers are very frequent. On the contrary, for the first time, we have encountered a perylene diimide-based organogel consisting of self-assembled nanotubes. The molecular interactions, molecular packing, and rheological properties of this organogel are also discussed.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Organogels Fabricated from Self-Assembled Nanotubes Containing Core Substituted Perylene Diimide Derivative

Moharana

Santosh

2022

ACS Omega

View full text Add to dashboard Cite

show abstract

Section: External Factors Responsive Hydrogels For Inflammation Therapymentioning

confidence: 99%

mentioning

confidence: 99%

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Yu,

Gao,

Liu

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, the efficient treatment of inflammation has always been the hot topic in the research of medicine. In the past decades, as a potential biomaterial, stimuli‐responsive hydrogels have been a focus of attention for the inflammation treatment due to their excellent biocompatibility and design flexibility. Recently, thanks to the rapid development of nanotechnology and material science, more and more efforts have been made to develop safer, more personal and more effective hydrogels for the therapy of some frequent but tough inflammations such as sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, and ulcerative colitis. Herein, from recent studies and articles, the conventional and emerging hydrogels in the delivery of anti‐inflammatory drugs and the therapy for various inflammations are summarized. And their prospects of clinical translation and future development are also discussed in further detail.

show abstract

“…Young's modulus G was calculated using the equation E = δσ/δε, where δσ is the stress and δε is the strain in the linear elastic region. Three separate measurements were performed for each sample [28].…”

Section: Microrheology Experimentsmentioning

confidence: 99%

“…Hydrogels can promote the release of encapsulated drug molecules via environmental changes when the target drug is enclosed in a hydrogel matrix. In recent years, hydrogel materials and drug-loaded hydrogels have been used as antiparasitics due to their mechanical strength, high stability, large drug loading capacity, and long release time [26][27][28]. Hydrogels are typically made of natural [29] or synthetic polymers [30].…”

Section: Introductionmentioning

confidence: 99%

A Novel Gelatin-Based Sustained-Release Molluscicide for Control of the Invasive Agricultural Pest and Disease Vector Pomacea canaliculata

et al. 2022

View full text Add to dashboard Cite

Pomacea canaliculata, one of the 100 most destructive invasive species in the world, and it is an important intermediate host of Angiostrongylus cantonensis. The molluscicides in current use are an effective method for controlling snails. However, most molluscicides have no slow-release effect and are toxic to nontarget organisms. Thus, these molluscicides cannot be used on a large scale to effectively act on snails. In this study, gelatin, a safe and nontoxic substance, was combined with sustained-release molluscicide and was found to reduce the toxicity of niclosamide to nontarget organisms. We assessed the effects of gelatin and molluscicide in controlling P. canaliculata snails and eggs. The results demonstrated that the niclosamide retention time with 1.0% and 1.5% gelatin sustained-release agents reached 20 days. Additionally, the mortality rate of P. canaliculata and their eggs increased as the concentration of the niclosamide sustained-release agents increased. The adult mortality rate of P. canaliculata reached 50% after the snails were exposed to gelatin with 0.1 mg/L niclosamide for 48 h. The hatching rate of P. canaliculata was only 28.5% of the normal group after the treatment was applied. The sustained-release molluscicide at this concentration was less toxic to zebrafish, which means that this molluscicide can increase the safety of niclosamide to control P. canaliculata in aquatic environments. In this study, we explored the safety of using niclosamide sustained-release agents with gelatin against P. canaliculata. The results suggest that gelatin is an ideal sustained-release agent that can provide a foundation for subsequent improvements in control of P. canaliculata.

show abstract

Ultrasound-Induced Amino Acid-Based Hydrogels With Superior Mechanical Strength for Controllable Long-Term Release of Anti-Cercariae Drug

Cited by 7 publications

References 36 publications

Organogels Fabricated from Self-Assembled Nanotubes Containing Core Substituted Perylene Diimide Derivative

Organogels Fabricated from Self-Assembled Nanotubes Containing Core Substituted Perylene Diimide Derivative

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

A Novel Gelatin-Based Sustained-Release Molluscicide for Control of the Invasive Agricultural Pest and Disease Vector Pomacea canaliculata

Contact Info

Product

Resources

About