Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases

Wang, Jieqiong; Li, Zhenzhou; Pan, Min; Fiaz, Muhammad; Hao, Yongsheng; Yan, Yiran; Sun, Litao; Yan, Fei

doi:10.1016/j.addr.2022.114539

Cited by 61 publications

(36 citation statements)

References 186 publications

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“…research is necessary to strike a balance between the safety and efficacy of MRgFUS-induced BBB penetration for treating CNS diseases. [165,178] Another physical stimulus for promoting BBB penetration is EMF, especially when used in combination with magnetic nanoparticles (MNPs). [183,184] For example, Gupta et al combined external magnetic fields and alternating magnetic fields (AMF) to enhance the brain delivery of MNPs.…”

Section: Strategies For Overcoming the Bbbmentioning

confidence: 99%

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Lu,

Wei,

Shi

et al. 2024

Advanced Science

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Current management of anesthesia‐associated complications falls short in terms of both efficacy and safety. Nanomaterials with versatile properties and unique nano‐bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a thorough examination of the existing nanotherapeutics and highlights the strategies for developing prospective nanomedicines to mitigate anesthetics‐related toxicity. Initially, general, regional, and local anesthesia along with the commonly used anesthetics and related prevalent side effects are introduced. Furthermore, employing nanotechnology to prevent and alleviate the complications of anesthetics is systematically demonstrated from three aspects, that is, developing 1) safe nano‐formulization for anesthetics; 2) nano‐antidotes to sequester overdosed anesthetics and alter their pharmacokinetics; 3) nanomedicines with pharmacodynamic activities to treat anesthetics toxicity. Finally, the prospects and challenges facing the clinical translation of nanotherapeutics for anesthesia‐related complications are discussed. This work provides a comprehensive roadmap for developing effective nanotherapeutics to prevent and mitigate anesthesia‐associated toxicity, which can potentially revolutionize the management of anesthesia complications.

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Section: Strategies For Overcoming the Bbbmentioning

confidence: 99%

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Lu,

Wei,

Shi

et al. 2024

Advanced Science

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“… Type of application Methodology utilized Disease condition/process influenced Reference Neurological applications Thermal ablation with high intensity ultrasound (1–3 MHz); Mechanical effect with medium intensity (>100 kHz); non-thermal effect (<100 kHz). Brain ablation with focused ultrasound Parkinson's, essential tremors, pain, neuropsychiatric conditions [ 205 ] MR guided focused ultrasound Essential tremors [ 206 , 207 ] MR-guided pallidotomy with FUS Parkinson's disease [ 208 ] Focused ultrasound Crossing blood brain barrier [ 209 ] Focused ultrasound Neurovascular conditions [ 210 ] MR guided focused ultrasound Angiogenesis during cerebral hemorrhagic stroke Cardiovasular applications Ultrasound in B-mode Characterization vascular muscle walls [ 211 ] Ultrasound in M-mode Blood vessel movements [ 212 ] Doppler mode Blood flow characteristics [ 213 ] Phospholipid-based microbubbles enhanced ultrasound Endocardial imaging [ 214 ] ICAM-1 mediated targeting of endothelial cells Ischemia [ 215 ] P-selectin Cardiac imaging [ 216 ] Microbubble loaded VCAM-1, ICAM-1 and P-selectin Atherosclerosis [ 217 ] Fibrin targeted microbubble Thromboembolism and acute coronary syndrome [ 218 ] αIIbβ3 complex co-loaded with urokinase Delivery to site of thrombus [ …”

Section: Research and Development In Ultrasound-based Applications In...mentioning

confidence: 99%

“…Ultrasound has also shown potential in improving the pharmaceutical properties of therapeutic drugs through efficient drug delivery across the blood brain barrier (BBB), also in drug sensitization using low-intensity acoustic waves at the target site and further help in drug internalization by sonoporation process [ 206 ]. Facilitating a drug to cross the BBB is one of the unsolved struggles in pharmacokinetic research and FUS has shown significant promise in this regard with transient opening of BBB through cavitation and microbubble injection [ 207 , 281 ].…”

Section: Research and Development In Ultrasound-based Applications In...mentioning

confidence: 99%

Exosomes and ultrasound: The future of theranostic applications

Sridharan

Lim

2023

Materials Today Bio

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“…The environmental fate of different biocides is relatively poorly understood, with nearly all data derived from the assessment reports on biodegradation [4]. In addition, the role of biocides in the search and design of drugs is quite noticeable [5][6][7][8][9][10][11]. Biocidal products are used in homes for hygienic purposes or in industries to control the growth of bacteria [12].…”

Section: Introductionmentioning

confidence: 99%

The validation of predictive potential via the system of self-consistent models: the simulation of blood-brain barrier permeation of organic compounds

Toropova

Toropov

Roncaglioni

et al. 2023

Preprint

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In order to apply quantitative relationships "structure-endpoint" approach its reliability of prediction is necessary but sometimes challenging to achieve. Here, an attempt is made to accomplish the reliability of forecasts by creating a set of random partitions of data into training and validation sets, followed by constructing random models. A system of random models for a useful approach should be self-consistent, giving a similar or at least comparable statistical quality of the predictions for models obtained using different splits of available data into training and validation sets. Developed computer experiments aimed at obtaining blood-brain barrier permeation models showed that, in principle, such an approach can be used for the above purpose taking advantage of specific algorithms to optimize the modelling steps. Results so obtained are good, and better than what reported previously. The suggested approach to validation of models is non-identic to traditionally applied manners of the checking up models. The concept of validation can be used for arbitrary models (not only for models of the blood-brain barrier).

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Ultrasound-mediated blood–brain barrier opening: An effective drug delivery system for theranostics of brain diseases

Cited by 61 publications

References 186 publications

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Exosomes and ultrasound: The future of theranostic applications

The validation of predictive potential via the system of self-consistent models: the simulation of blood-brain barrier permeation of organic compounds

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