Ultrasound-Mediated Cancer Therapy as a Noninvasive and Repeatable Treatment Strategy

Darwinian Principles toward Multidrug-Resistant Cancer Cells

“…To ensure the maximum clinical benefits by destruction of the greatest possible number of cancer cells, the clinicians prescribe the maximum tolerated dose of chemotherapy [2][3][4]. However, this treatment method leads to some side effects for patients such as systemic toxicity, drug resistance and potential longterm side effects [5][6][7]. The attention and efforts of scientists had been, therefore, drawn to develop new chemotherapy treatment strategies to improve clinical benefits and reduce the side effects by taking into consideration the impact of dose intensity, dose density, and treatment duration [3].…”