Ultrasound mediated therapy: Recent progress and challenges in nanoscience

Ouyang, Jun; Tang, Zhongmin; Farokhzad, Nika; Kong, Na; Kim, Na Yoon; Feng, Chan; Blake, Sara; Xiao, Yufen; LIU, Chuang; Xie, Tian; Tao, Wei

doi:10.1016/j.nantod.2020.100949

Cited by 198 publications

(146 citation statements)

References 67 publications

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“…[ 132,133 ] 3) Using other external fields to stimulate the PTT process. Just like radiodynamic therapy (RDT) [ 134 ] or sonodynamic therapy (SDT) [ 135,136 ] using X‐ray or ultrasound with deep penetration to trigger the generation of ROS, the PTT can also be triggered by other external fields through exquisite design. 4) Get rid of external fields.…”

Section: Discussionmentioning

confidence: 99%

Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer

Wang

et al. 2021

Adv Healthcare Materials

265

145

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It is of great significance to develop anticancer therapeutic agents or technologies with high degree of specificity and patient compliance, while low toxicity. The emerging photothermal therapy (PTT) has become a new and powerful therapeutic technology due to its noninvasiveness, high specificity, low side effects to normal tissues and strong anticancer efficacy. Noble metal nanomaterials possess strong surface plasmon resonance (SPR) effect and synthetic tunability, which make them facile and effective PTT agents with superior optical and photothermal characteristics, such as high absorption cross‐section, incomparable optical‐thermal conversion efficiency in the near infrared (NIR) region, as well as the potential of bioimaging. By incorporating with various functional reagents such as antibodies, peptides, biocompatible polymers, chemo‐drug and immune factors, noble metal nanomaterials have presented strong potential in multifunctional cancer therapy. Herein, the recent development regarding the application of noble metal nanomaterials for NIR‐triggered PTT in cancer treatment is summarized. A variety of studies with good therapeutic effects against cancer from impressive photothermal efficacy of noble metal nanomaterials are concluded. Intelligent nanoplatforms through ingenious fabrication showing potential of multifunctional PTT, combined with chemo‐therapy, immunotherapy, photodynamic therapy (PDT), as well as simultaneous imaging modality are also demonstrated.

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Section: Discussionmentioning

confidence: 99%

Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer

Wang

et al. 2021

Adv Healthcare Materials

265

145

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“…As an emerging and promising therapeutic approach, ultrasound (US)-triggered sonodynamic therapy (SDT) has been rapidly developed as an alternative technique for cancer treatment with specific features of non-invasiveness, deep tissue-penetrating capability, high controllability and low cost [ 28 , 29 ]. US can activate sonosensitizers to generate large amounts of high energy oxygen-containing reactive oxygen species (ROS), mainly singlet oxygen ( 1 O 2 ) through acoustic cavitation-induced effects, such as sonoluminescence (SL) and pyrolysis, thereby inducing necrosis or apoptosis of cancer cells [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics

et al. 2021

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Ultrasound-triggered sonodynamic therapy (SDT) represents an emerging therapeutic modality for cancer treatment based on its specific feature of noninvasiveness, high tissue-penetrating depth and desirable therapeutic efficacy, but the SDT-induced pro-survival cancer-cell autophagy would significantly lower the SDT efficacy for cancer treatment. Here we propose an “all-in-one” combined tumor-therapeutic strategy by integrating nanosonosensitizers-augmented noninvasive SDT with autophagy inhibition based on the rationally constructed nanoliposomes that co-encapsulates clinically approved sonosensitizers protoporphyrin IX (PpIX) and early-phase autophagy-blocking agent 3-methyladenine (3-MA). It has been systematically demonstrated that nanosonosensitizers-augmented SDT induced cytoprotective pro-survival autophagy through activation of MAPK signaling pathway and inhibition of AMPK signaling pathway, and this could be efficaciously inhibited by 3-MA in early-phase autophagy, which significantly decreased the cell resistance to intracellular oxidative stress and complied a remarkable synergistic effect on SDT medicated cancer-cell apoptosis both in vitro at cellular level and in vivo on tumor-bearing animal model. Therefore, our results provide a proof-of-concept combinatorial tumor therapeutics based on nanosonosensitizers for the treatment of ROS-resistant cancer by autophagy inhibition-augmented SDT.

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“…However, their long‐lasting skin sensitivity, low chemical stability, poor tumor accumulation, and high dose‐dependent toxicity have hindered their further applications in clinical settings. Additionally, the hydrophobic nature of most of these small molecules makes them easily aggregate in the physiological environment, thereby reducing their bioavailability and ROS generation efficiency [7] . To solve the unmet needs the past years have seen a focus on the synthesis of biocompatible inorganic nanomaterial‐based sonosensitizers such as titanium dioxide (TiO 2 ), zinc oxide (ZnO) nanomaterials, and their nanocomposites [11–13] .…”

Section: Introductionmentioning

confidence: 99%

“…Yet, PDT suffers from low tissue‐penetrating depth (on the order of millimeters) and inherent phototoxicity from the photosensitizers, thereby hindering the treatment efficacy for deep‐seated tumors and producing undesirable side effects [4] . To address these shortcomings, ultrasound (US)‐mediated sonodynamic therapy (SDT) has recently emerged as a powerful modality for disease treatments owing to the non‐invasiveness, spatiotemporal controllability, and most importantly, high tissue‐penetrating depth (on the order of centimeters) [5–7] . Consequently, compared with PDT, SDT has become a superior noninvasive modality for disease treatments.…”

Section: Introductionmentioning

confidence: 99%

“…[4] To address these shortcomings,ultrasound (US)-mediated sonodynamic therapy (SDT) has recently emerged as ap owerful modality for disease treatments owing to the non-invasiveness,s patiotemporal controllability,a nd most importantly, high tissue-penetrating depth (on the order of centimeters). [5][6][7] Consequently,compared with PDT,SDT has become as uperior noninvasive modality for disease treatments. Similar to PDT,t he execution of SDT relies on the efficient separation of electron (e À )-hole (h + )p airs within the USactivated sonosensitizers;t he e À and h + ,a nd the energy released from the activated sonosensitizers could further react with the surrounding O 2 and H 2 Omolecules to generate cytotoxic ROS (e.g., 1 O 2 ,a nd COH).…”

Section: Introductionmentioning

confidence: 99%

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Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

Chen

LIU

et al. 2021

Angewandte Chemie

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Ultrasound (US)‐mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non‐invasiveness and high tissue‐penetrating depth. However, developing biocompatible nanomaterial‐based sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid‐phase exfoliation strategy to obtain a new type of two‐dimensional (2D) stanene‐based nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nano‐sonosensitizers, allowing a more efficient US‐triggered separation of electron (e−)‐hole (h+) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near‐infrared (NIR)‐mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT‐enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine.

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Ultrasound mediated therapy: Recent progress and challenges in nanoscience

Cited by 198 publications

References 67 publications

Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer

Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer

Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics

Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

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