Ultrasound–Microwave Combined Extraction of Novel Polysaccharide Fractions from Lycium barbarum Leaves and Their In Vitro Hypoglycemic and Antioxidant Activities

Quan, Ning; Wang, Yidan; Li, Guorong; Liu, Ziqi; Feng, Jing; Qiao, Chunlei; Zhang, Hua-Feng

doi:10.3390/molecules28093880

Cited by 14 publications

(3 citation statements)

References 26 publications

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“…During this process, the enzymes break down the plant cell wall into small molecules, then intracellular L. japonica polysaccharides are rapidly released in the external medium. However, a combination of multiple methods is preferred to a single extraction method [ 33 , 34 ]. The Ultrasonic-assisted enzymatic extraction (UAEE) method is a combination of ultrasonic extraction technology and enzymatic hydrolysis, and has a high extraction rate, short extraction time, low extraction temperature, and high efficiency [ 35 , 36 ].…”

Section: Extraction and Purification Methods Of L Japonica ...mentioning

confidence: 99%

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Yang,

Yu,

et al. 2023

Molecules

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Lonicera japonica Thunb. is a widely distributed plant with ornamental, economic, edible, and medicinal values. L. japonica is a phytoantibiotic with broad-spectrum antibacterial activity and a potent therapeutic effect on various infectious diseases. The anti-diabetic, anti-Alzheimer’s disease, anti-depression, antioxidative, immunoregulatory, anti-tumor, anti-inflammatory, anti-allergic, anti-gout, and anti-alcohol-addiction effects of L. japonica can also be explained by bioactive polysaccharides isolated from this plant. Several researchers have determined the molecular weight, chemical structure, and monosaccharide composition and ratio of L. japonica polysaccharides by water extraction and alcohol precipitation, enzyme-assisted extraction (EAE) and chromatography. This article searched in the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, and CNKI databases within the last 12 years, using “Lonicera. japonica polysaccharides”, “Lonicera. japonica Thunb. polysaccharides”, and “Honeysuckle polysaccharides” as the key word, systematically reviewed the extraction and purification methods, structural characteristics, structure-activity relationship, and health benefits of L. japonica polysaccharides to provide insights for future studies. Further, we elaborated on the potential applications of L. japonica polysaccharides in the food, medicine, and daily chemical industry, such as using L. japonica as raw material to make lozenges, soy sauce and toothpaste, etc. This review will be a useful reference for the further optimization of functional products developed from L. japonica polysaccharides.

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Section: Extraction and Purification Methods Of L Japonica ...mentioning

confidence: 99%

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Yang,

Yu,

et al. 2023

Molecules

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“…The results showed that the optimal conditions of LBP extraction using combined methods were 16 min for microwave extraction, 20 min for ultrasound extraction, and liquid-solid ratio of 55:1. Under these optimized conditions, the polysaccharide yield was 1.873% [22].…”

Section: Active Ingredients 21 Lycium Barbarum Polysaccharidementioning

confidence: 97%

Bioactive Components of Lycium barbarum and Deep-Processing Fermentation Products

Qiang,

Xia,

Geng

et al. 2023

Molecules

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Lycium barbarum, a homology of medicine and food, contains many active ingredients including polysaccharides, polyphenol, betaine, and carotenoids, which has health benefits and economic value. The bioactive components in Lycium barbarum exhibit the effects of antioxidation, immune regulation, hypoglycemic effects, and vision improvement. Recently, the development of nutrition and health products of Lycium barbarum has been paid more and more attention with the increase in health awareness. A variety of nutrients and bioactive components in wolfberry can be retained or increased using modern fermentation technology. Through fermentation, the products have better flavor and health function, which better meet the needs of market diversification. The main products related to wolfberry fermentation include wolfberry fruit wine, wolfberry fruit vinegar, and lactic acid fermented beverage. In this review, the mainly bioactive components of Lycium barbarum and its deep-processing products of fermentation were summarized and compared. It will provide reference for the research and development of fermented and healthy products of Lycium barbarum.

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“…It has been identified that the polysaccharides from Lycium barbarum leaves hinder α-amylase enzyme activity in a dose-dependent manner [ 149 ]. Another polysaccharide (SGP-1-1), isolated from Siraitia grosvenorii, showed α-amylase inhibition with the best inhibition of 61.73% [ 148 ].…”

Section: Secondary Metabolites Isolated From Various Plant Sources As...mentioning

confidence: 99%

New Insights into the Latest Advancement in α-Amylase Inhibitors of Plant Origin with Anti-Diabetic Effects

Kashtoh

Baek

2023

Plants

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The rising predominance of type 2 diabetes, combined with the poor medical effects seen with commercially available anti-diabetic medications, has motivated the development of innovative treatment approaches for regulating postprandial glucose levels. Natural carbohydrate digestion enzyme inhibitors might be a viable option for blocking dietary carbohydrate absorption with fewer side effects than manufactured medicines. Alpha-amylase is a metalloenzyme that facilitates digestion by breaking down polysaccharides into smaller molecules such as maltose and maltotriose. It also contributes to elevated blood glucose levels and postprandial hyperglycemia. As a result, scientists are being urged to target α-amylase and create inhibitors that can slow down the release of glucose from carbohydrate chains and prolong its absorption, thereby resulting in lower postprandial plasma glucose levels. Natural α-amylase inhibitors derived from plants have gained popularity as safe and cost-effective alternatives. The bioactive components responsible for the inhibitory actions of various plant extracts have been identified through phytochemical research, paving the way for further development and application. The majority of the findings, however, are based on in vitro investigations. Only a few animal experiments and very few human investigations have confirmed these findings. Despite some promising results, additional investigation is needed to develop feasible anti-diabetic drugs based on plant-derived pancreatic α-amylase inhibitors. This review summarizes the most recent findings from research on plant-derived pancreatic α-amylase inhibitors, including plant extracts and plant-derived bioactive compounds. Furthermore, it offers insights into the structural aspects of the crucial therapeutic target, α-amylases, in addition to their interactions with inhibitors.

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Ultrasound–Microwave Combined Extraction of Novel Polysaccharide Fractions from Lycium barbarum Leaves and Their In Vitro Hypoglycemic and Antioxidant Activities

Cited by 14 publications

References 26 publications

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from Lonicera japonica Thunb.: A Review

Bioactive Components of Lycium barbarum and Deep-Processing Fermentation Products

New Insights into the Latest Advancement in α-Amylase Inhibitors of Plant Origin with Anti-Diabetic Effects

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