Ultrasound Pathological Changes under Function and Microscope Observation after Sciatic Nerve in Rats

Abstract

The most common case of contemporary neuro-orthopedics and neurosurgery is sciatic nerve injury, but after the sciatic nerve is severed, it cannot be cured by medical surgery. Objective: To restore the damaged sciatic nerve to normal function. Methods: The rat model of sciatic nerve injury was made by operation after anastomosis of the sciatic nerve. A blank control group, model group and NT-3 treatment group were set up. Compare the recovery of rat sciatic nerve function and the pathological changes under the microscope before and after treatment. Results: The sciatic nerve function index of the rats before injury was all above 9, and the nerve function was completely normal. The SFI value of the high-dose group was close to 0 after the fourth week, which was significantly different from other groups (P <0.05), and its intensity Related to the concentration, the high-dose group had the most significant effect after statistical treatment; the recovery rate of calf triceps wet weight in the NT-3 high-dose group was higher than that of the other experimental groups, and the recovery rate at the sixth week was 77.35 %.The treatment effect is significant (P <0.01), the amplitude of the sciatic nerve action potential of rats before injury is higher than the amplitude of the sciatic nerve action potential of rats after injury, and the NT-3 high-dose group basically recovered to Normal nerve action potential amplitude (11.21). Conclusion: NT-3 can speed up the recovery of sciatic nerve function after sciatic nerve dissection.