Ultrasound Phantom Using Sodium Alginate as a Gelling Agent

Aoyagi, Mutsumi; Hiraguri, Tomomi

doi:10.1002/jum.14252

Cited by 10 publications

(3 citation statements)

References 39 publications

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“…Alternatively, to water that exhibits negligible attenuation coefficient, ultrasonic waves undergo attenuation when they are transmitted in more viscous mediums, such as the one formed by alginate and fibrin. [44][45][46] Hence, with a lower acoustic field inside the beads, the odds of inducing cytotoxic effects such as acoustic cavitation or radical liberation are significantly reduced. Furthermore, the magnitude of hydrogen peroxide formation in aqueous solutions is dependent on the mechanical index, frequency and duration of sonication, and the formation of hydrogen peroxide was found to be low at 1 MHz [25,47] or short sonication time.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Mediated Polymerization for Cell Delivery, Drug Delivery, and 3D Printing

Debbi,

Machour,

Dahis

et al. 2024

Small Methods

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Safe and accurate in situ delivery of biocompatible materials is a fundamental requirement for many biomedical applications. These include sustained and local drug release, implantation of acellular biocompatible scaffolds, and transplantation of cells and engineered tissues for functional restoration of damaged tissues and organs. The common practice today includes highly invasive operations with major risks of surgical complications including adjacent tissue damage, infections, and long healing periods. In this work, a novel non‐invasive delivery method is presented for scaffold, cells, and drug delivery deep into the body to target inner tissues. This technology is based on acousto‐sensitive materials which are polymerized by ultrasound induction through an external transducer in a rapid and local fashion without additional photoinitiators or precursors. The applicability of this technology is demonstrated for viable and functional cell delivery, for drug delivery with sustained release profiles, and for 3D printing. Moreover, the mechanical properties of the delivered scaffold can be tuned to the desired target tissue as well as controlling the drug release profile. This promising technology may shift the paradigm for local and non‐invasive material delivery approach in many clinical applications as well as a new printing method – “acousto‐printing” for 3D printing and in situ bioprinting.

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Section: Discussionmentioning

confidence: 99%

Ultrasound Mediated Polymerization for Cell Delivery, Drug Delivery, and 3D Printing

Debbi,

Machour,

Dahis

et al. 2024

Small Methods

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“…The application of liquid gels allows good ultrasound penetrations for distinct image formation, but also causes inconvenience as the gel needs to be cleaned after therapy. To avoid this inconvenience, ultrasound transmitting coats have been proposed (Aoyagi and Hiraguri 2017): the ultrasound probe can be wrapped with a silicone coat or a plastic bag lled with water to perform ultrasound analyses without smearing liquid gels over human body. Among various materials, hydrogels catch widespread attention due to their great ultrasound transmittance and bio-compatibility.…”

Section: Introductionmentioning

confidence: 99%

Highly compressible hydrogel reinforced with cellulose nanocrystals for ultrasound scanning via microwave-assisted synthesis

Cheng

Liao

et al. 2022

Cellulose

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In this study, a rapid fabrication method was developed to prepare hydrogel structures with high mechanical strength and low attenuation coe cient for ultrasound scanning. Poly acrylic acid (PAA) hydrogel was rst prepared via a free radical polymerization approach. To shorten the process time (~ 30 minutes in water bath), microwave heating was applied to facilitate the reaction and reduce the reaction time down to 80 seconds. The produced hydrogels showed excellent elasticity but had a low compressive strength of 100 kPa. To further enhance the mechanical strengths of PAA hydrogels, cellulosenanocrystals (CNCs) were added to the precursor solution. After the microwave assisted crosslinking process, the compressive strength of the hydrogel increased to 350 kPa. Moreover, the ultimate compressive strain was enhanced from 60% to 80% with great recoverability. The PAA/CNC hydrogel has a great ultrasound trnansimission for high-quality ultrasound images comparable to conventional liquid hydrogels. To demonstrate the feasibility of the PAA/CNC hydrogel in ultrasonic medical applications, a customized ultrasound probe coat was created with a 3D printed mold and practically used in the ultrasound scanning process.

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“…I have been studying handmade ultrasound phantoms that mimic human soft tissue. 19 A phantom that I proposed comprised a calcium alginate hydrogel synthesized from sodium alginate, calcium sulfate dihydrate, trisodium phosphate 12-hydrate, glycerol, and water in a mass ratio of 3:4:2:15:100. This ultrasound phantom is low-cost and easy to fabricate without special equipment.…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate Ultrasound Phantom for Medical Education

Aoyagi

2021

Ultrason Imaging

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The ultrasound phantoms used to educate medical students should not only closely mimic the ultrasound characteristics of human soft tissues but also be inexpensive and easy to manufacture. I have been studying handmade ultrasound phantoms and proposed an ultrasound phantom comprising calcium alginate hydrogel that met these requirements but caused a speckle pattern similar to that observed in ultrasound images of liver. In this study, I show that adding ethanol to the precursors used to fabricate the phantom reduces the speckle pattern. The ultrasound propagation velocity and attenuation coefficient of the phantom were 1561 ± 8 m/s and 0.54 ± 0.18 dB/cm/MHz, respectively (mean ± standard deviation), which are within the ranges of those in human soft tissues (1530-1600 m/s and 0.3-1.0 dB/cm/MHz, respectively). This phantom is easy to fabricate without special equipment, is inexpensive, and is suitable for elementary training on ultrasound diagnosis, operation of ultrasound-guided needles, and blind catheter insertion.

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Ultrasound Phantom Using Sodium Alginate as a Gelling Agent

Cited by 10 publications

References 39 publications

Ultrasound Mediated Polymerization for Cell Delivery, Drug Delivery, and 3D Printing

Ultrasound Mediated Polymerization for Cell Delivery, Drug Delivery, and 3D Printing

Highly compressible hydrogel reinforced with cellulose nanocrystals for ultrasound scanning via microwave-assisted synthesis

Sodium Alginate Ultrasound Phantom for Medical Education

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