Ultrasound Phonophoresis of Panax Notoginseng Improves the Strength of Repairing Ligament: A Rat Model

Ng, Gabriel Y.F.; Wong, Richard Y.F.

doi:10.1016/j.ultrasmedbio.2008.04.017

Cited by 11 publications

(9 citation statements)

References 30 publications

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“…Other recent studies that have utilized HFS for increased percutaneous absorption to treat local ailments include: i) aloe vera, a common skin moisturizer or skin healing agent,[83] ii) Arnica montana , a plant extract used to treat inflammatory muscle lesions,[135] iii) dimethylsulfoxide, for the treatment of local muscle damage and oxidative stress,[132] panax notoginseng, an herbal extract used to increase strength of local ligament repair,[233] and v) sinomenine, a morphinan derivative used in the treatment of rheumatism and arthritis. [111] In nearly all of these studies, the combination of HFS treatment with the active agent showed increased benefit over passive treatment with the drug alone.…”

Section: Emerging Trends In Sonophoresismentioning

confidence: 99%

Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends

Polat

Hart

Langer

et al. 2011

Journal of Controlled Release

357

290

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The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (≥ 0.7 MHz) for sonophoresis (HFS) dates back to as early as the 1950s, while low-frequency sonophoresis (LFS, 20 – 100 kHz) has only been investigated significantly during the past two decades. Although HFS and LFS are similar because they both utilize ultrasound to increase the skin penetration of permeants, the mechanisms associated with each physical enhancer are different. Specifically, the location of cavitation and the extent to which each process can increase skin permeability are quite dissimilar. Although the applications of both technologies are different, they each have strengths that could allow them to improve current methods of local, regional, and systemic drug delivery. In this review, we will discuss the mechanisms associated with both HFS and LFS, specifically concentrating on the key mechanistic differences between these two skin treatment methods. Background on the relevant physics associated with ultrasound transmitted through aqueous media will also be discussed, along with implications of these phenomena on sonophoresis. Finally, a thorough review of the literature is included, dating back to the first published reports of sonophoresis, including a discussion of emerging trends in the field.

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Section: Emerging Trends In Sonophoresismentioning

confidence: 99%

Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends

Polat

Hart

Langer

et al. 2011

Journal of Controlled Release

357

290

View full text Add to dashboard Cite

show abstract

“…Ng et al [84] examined the phonophoretic effect of a therapeutic ULTS coupled with a Panax notoginseng (PN) gel and compared it with a therapeutic ULTS alone for medial collateral ligament repair in rats. Twenty mature male Sprague-Dawley rats receiving surgical transection to the left medial collateral ligament (MCL) were divided randomly into three groups: ULTS, ULTS with PN coupling gel and control.…”

Section: Panax Notoginsengmentioning

confidence: 99%

The Use of Sonophoresis in the Administration of Drugs Throughout the Skin

et al. 2009

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Abstract Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injection. However, the stratum corneum acts as a barrier that limits the penetration of substances through the skin. Application of ultrasound to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. Ultrasound has been used extensively for medical diagnostics and to a certain extent in medical therapy (physiotherapy, ultrasonic surgery, hyperthermia). Nevertheless, it has only recently become popular as a technique to enhance drug release from drug delivery systems. A number of studies suggest the use of ultrasound as an external mean of delivering drugs at increased rates and at desired times. This review presents the main findings in the field of sonophoresis, namely transdermal drug delivery and transdermal monitoring. Particular attention is paid to proposed enhancement mechanisms and trends in the field of topical and transdermal delivery.

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“…bFGF is a hydrophilic protein with a molecular weight of approximately 18 kDa. In addition, earlier studies have demonstrated the potential of LFS to treat chronic soft tissue lesions [32][33][34]. Reasonably, bFGF delivered by LFS is supposed to be able to overcome the SC barrier into the deeper layers of the skin and remain intact in vivo to exert its pharmacological effect.…”

Section: Evaluation Of the Hypothesis/ideamentioning

confidence: 99%

Transdermal bFGF delivery using low-frequency sonophoresis: An innovative potential therapy for osteoradionecrosis of jaws

Zhou

Wang

Lang

et al. 2015

Journal of Medical Hypotheses and Ideas

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Osteoradionecrosis of jaws (ORNJ) is a serious complication of radiotherapy for patients with head and neck cancer. As of yet, no universally accepted treatment exists for this chronic pathologic condition. It has been shown that ultrasound is an effective, noninvasive adjunctive therapy in ORNJ, as ultrasound can result in the increase of angiogenesis and bone production, which are essential for ORNJ healing. Recently, low-frequency ultrasound has been demonstrated to enhance the transdermal delivery of macromolecules and hydrophilic drugs (low-frequency sonophoresis, LFS). As a biological macromolecule, basic fibroblast growth factor (bFGF) also has potential osteoinductive and angiogenic properties. Herein, we present a hypothesis that LFS-mediated transdermal bFGF delivery is capable of improving the healing of ORNJ and will be a new effective adjunctive therapy to surgery. This treatment combines low-frequency ultrasound with bFGF to respectively promote vascularly compromised bone and soft tissue wound healing, and is expected to be more effective than ultrasound therapy alone.

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Ultrasound Phonophoresis of Panax Notoginseng Improves the Strength of Repairing Ligament: A Rat Model

Cited by 11 publications

References 30 publications

Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends

Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends

The Use of Sonophoresis in the Administration of Drugs Throughout the Skin

Transdermal bFGF delivery using low-frequency sonophoresis: An innovative potential therapy for osteoradionecrosis of jaws

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