“…7 In addition, some sulfones exhibited a broad spectrum of pharmacological activities such as antitumoral activity; 8 inhibitors of cruzain, 9 a cysteine protease that plays a crucial role in the life cycle of Trypanosoma cruzi, the etiologic agent of Chagas' disease; and inhibitors of falcipain-2, 10 a cysteine protease that plays an important role in the parasitic life-cycle (Figure 1). There are several methods described in the literature for the preparation of this class of compounds being the most common those based on decarboxylative methods 11 or sulfonylation reactions employing different classes of sulfur compounds such as sulfonylhydrazides, 12 sulfonyl halides, 13 sulfinamides, 14 sulfinates, 15 thiosulfonates, 16 thiols, 17 SO2, 18 and tosylhydrazones. 19 The use of salts of organosulfinic acids emerged as an alternative to the methods described above.…”