This systematic review aims to evaluate the role of ultrasound (US) radiomics in assessing
lymphadenopathy in patients with cancer and the ability of radiomics to predict metastatic
lymph node involvement. A systematic literature search was performed in the PubMed (MEDLINE),
Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE (Ovid) databases up to
June 13, 2023. 42 articles were included in which the lymph node mass was assessed with a US
exam, and the analysis was performed using radiomics methods. From the survey of the selected
articles, experimental evidence suggests that radiomics features extracted from US images can
be a useful tool for predicting and characterizing lymphadenopathy in patients with breast,
head and neck, and cervical cancer. This noninvasive and effective method allows the
extraction of important information beyond mere morphological characteristics, extracting
features that may be related to lymph node involvement. Future studies are needed to
investigate the role of US-radiomics in other types of cancers, such as melanoma.