Ultrasound-responsive matters for biomedical applications

Huang, Dongzhou; Wang, Jinglin; Song, Chuanhui; Zhao, Yuanjin

doi:10.1016/j.xinn.2023.100421

Cited by 24 publications

(17 citation statements)

References 103 publications

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“…The low-frequency ultrasound pulses have received clinical approval in the United States for accelerating bone repair in the treatment of new fractures and osteonecrosis, 123,124 and delivery of osteogenesis-related drugs or factors via ultrasound stimulation can increase drug delivery efficiency and improve osseointegration. 112 Sonosensitizers are also an important factor in determining the effectiveness of SDT, a large number of sonosensitizers have also been developed in the ongoing development of SDT. Sonosensitizers can be broadly categorized into organic and inorganic types.…”

Section: Sound-responsive Strategymentioning

confidence: 99%

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External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis

Liu,

Feng,

Ran

et al. 2024

ACS Appl. Mater. Interfaces

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Bacterial infection and insufficient osteogenic activity are the main causes of orthopedic implant failure. Conventional surface modification methods are difficult to meet the requirements for longterm implant placement. In order to better regulate the function of implant surfaces, especially to improve both the antibacterial and osteogenic activity, external stimuli-responsive (ESR) strategies have been employed for the surface modification of orthopedic implants. External stimuli act as "smart switches" to regulate the surface interactions with bacteria and cells. The balance between antibacterial and osteogenic capabilities of implant surfaces can be achieved through these specific ESR manifestations, including temperature changes, reactive oxygen species production, controlled release of bioactive molecules, controlled release of functional ions, etc. This Review summarizes the recent progress on different ESR strategies (based on light, ultrasound, electric, and magnetic fields) that can effectively balance antibacterial performance and osteogenic capability of orthopedic implants. Furthermore, the current limitations and challenges of ESR strategies for surface modification of orthopedic implants as well as future development direction are also discussed.

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Section: Sound-responsive Strategymentioning

confidence: 99%

“…Sonosensitizers can be broadly categorized into organic and inorganic types. 112 Organic sonosensitizers primarily include porphyrin derivatives, curcumin, and other organic compounds. Porphyrin derivatives such as hematoporphyrin (H.P.…”

Section: Sound-responsive Strategymentioning

confidence: 99%

External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis

Liu,

Feng,

Ran

et al. 2024

ACS Appl. Mater. Interfaces

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“…In recent decades, the rapid development of micro‐ and nano‐manufacturing technology has contributed to the advancement of autonomous robots 11,15,16,39,83–97 . In this mini review, we addressed several representative MNRs that can be sensitively actuated by the US.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…In recent decades, the rapid development of micro-and nano-manufacturing technology has contributed to the advancement of autonomous robots. 11,15,16,39,[83][84][85][86][87][88][89][90][91][92][93][94][95][96][97] In this mini review, we addressed several representative MNRs that can be sensitively actuated by the US. Attributing to the excellent biocompatibility, highly efficient penetrability, and low energy attenuation of US, the USpropelled MNRs have broader biomedical applications compared with other external energy fields.…”

Section: Future Perspectivesmentioning

confidence: 99%

Ultrasound‐trigged micro/nanorobots for biomedical applications

Huang

Cai

et al. 2023

Smart Medicine

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Micro-and nanorobots (MNRs) propelled by external actuations have broad potential in biomedical applications. Among the numerous external excitations, ultrasound (US) features outstanding practical significance with merits of its noninvasiveness, tunability, penetrability, and biocompatibility. Attributing to various physiochemical effects of US, it can propel the MNRs with sophisticated structures through asymmetric acoustic streaming, bubble oscillation, and so on. In this review, we introduce several advanced and representative US-propelled MNRs with inhomogeneous density distribution, asymmetric shape, hollow cavity, etc. The potential biomedical applications of these cutting-edge MNRs are also presented, including intracellular delivery, harmful substances collection, and so on. Furthermore, we conclude the advantages and limitations of US-propelled MNRs and prospect their future developments in multidisciplinary fields.

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“…Acoustic waves are a type of mechanical vibration that propagates through a medium by causing the compression and rarefaction of matter. [ 436 ] Briefly, sonosensitizer is the term commonly utilized to describe ultrasound‐responsive molecules/materials, which can produce reactive oxygen species when exposed to ultrasounds. Most of the molecular sonosensitizers are based on photosensitizers, including porphyrins, xanthenes, phenotiazines, and curcuminoids.…”

Section: Stimuli‐responsive Molecules Triggered By Different External...mentioning

confidence: 99%

Rational Design of Stimuli‐Responsive Inorganic 2D Materials via Molecular Engineering: Toward Molecule‐Programmable Nanoelectronics

Muñoz

2023

Advanced Materials

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The ability of electronic devices to act as switches makes digital information processing possible. Succeeding graphene, emerging Inorganic 2D Materials (i2DMs) have been identified as alternative 2D Materials to harbor a variety of active molecular components to move the current silicon‐based semiconductor technology forward to a post‐Moore era based on molecule‐based information processing components. In this regard, i2DMs benefits not only for their prominent physiochemical properties (e.g., the existence of band gap, contrary to graphene), but also their high surface‐to‐volume ratio rich in reactive sites (functionalization capability). Nonetheless, since this field is still in an early stage, having knowledge of both i) the different strategies for molecularly functionalizing the current library of i2DMs, and ii) the different types of active molecular components is a sine qua non condition for a rational design of stimuli‐responsive i2DMs capable of performing logical binary operations at the molecular level. Consequently, this Review provides a comprehensive tutorial for covalently anchoring ad hoc molecular components —as active units triggered by different external inputs— onto pivotal i2DMs to assess their role in the expanding field of Molecule‐Programmable Nanoelectronics for electrically monitoring bistable molecular switches. Limitations, challenges, and future perspectives of this emerging field which crosses materials chemistry with computation are critically discussed.This article is protected by copyright. All rights reserved

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Ultrasound-responsive matters for biomedical applications

Cited by 24 publications

References 103 publications

External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis

External Stimuli-Responsive Strategies for Surface Modification of Orthopedic Implants: Killing Bacteria and Enhancing Osteogenesis

Ultrasound‐trigged micro/nanorobots for biomedical applications

Rational Design of Stimuli‐Responsive Inorganic 2D Materials via Molecular Engineering: Toward Molecule‐Programmable Nanoelectronics

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