Ultrasound responsive self-assembled micelles loaded with hypocrellin for cancer sonodynamic therapy

Liu, Xuexue; Zhao, Kai; Cao, Jin; Qi, Xueyong; Wu, Lin; Shen, Song

doi:10.1016/j.ijpharm.2021.121052

Cited by 20 publications

(7 citation statements)

References 22 publications

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“…Upon the irradiation with US, the loaded sonosensitizer hypocrellin (HC) generated ROS to trigger the disassembly of the micelles and meanwhile realizing sonodynamic therapy against cancer. The in vivo experiment indicates that the HC loaded PEG-PPS are biocompatible and much more efficacious than an equivalent amount of free HC in inhibiting the growth of cancer [ 177 ].…”

Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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“…The ROS-responsive polymer PEG−PPS was prepared according to a previous report. 25 The method is shown in the Supporting Information. To prepare PEG−PPS−Fe 3 O 4 micelles, 300 μg of oil-dispersible Fe 3 O 4 NPs was dispersed in 100 μL of chloroform containing 100 mg of PEG−PPS polymer.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…The ROS-responsive polymer PEG–PPS was prepared according to a previous report . The method is shown in the Supporting Information.…”

Section: Experimental Sectionmentioning

confidence: 99%

Nanoscale Micelles Loaded with Fe₃O₄ Nanoparticles for Deep-Tissue Penetration and Ferroptosis/Sonodynamic Tumor Therapy

Shěn¹,

Liu

Jiang³

et al. 2022

ACS Appl. Nano Mater.

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Large nanoparticles (NPs; >100 nm) can accumulate in the tumor because of the enhanced permeation and retention effect. However, large NPs generally locate next to the blood vessel and are difficult to diffuse within a dense collagen matrix, causing uneven distribution within the tumor. Here, we designed reversibly assembled and disassembled micelles loaded with Fe 3 O 4 and hypocrellin (HC) for ferroptosis and sonodynamic therapy of cancer. Poly(ethylene glycol)−poly(propylene sulfide) (PEG−PPS), an reactive oxygen species (ROS)-responsive amphiphilic polymer, was used to form micelles with Fe 3 O 4 and HC in the core. Upon ultrasound irradiation, ROS was generated by HC for the disassembly of micelles and also for sonodynamic therapy, while realizing a size switch. The released Fe 3 O 4 dissolves to produce Fe 2+ , which catalyzes hydrogen peroxide to form hydroxyl radicals ( • OH). Sonodynamic and ferroptosis therapies generate a synergistic antitumor effect, offering a smart platform for cancer therapy.

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“…In particular, we have prepared molecular sonosensitizer-loaded biopolymer micelles, studied the nature of ROS generated under the ultrasound exposure, and investigated their ultrasound-based cell therapy performance. Although previous studies have used sonosensitizer-loaded micelles, − we have used a poly(ethylene glycol)–poly(lactide) (PEG–PLA)-based polymer nanomicelle of <100 nm size, which is biodegradable and biocompatible. It offers solubilization of poorly water-soluble sonosensitizers in its hydrophobic core and enhances their cellular uptake.…”

Section: Introductionmentioning

confidence: 99%

Molecular Sonosensitizer-Loaded Polymer Nanomicelle for Ultrasound-Based Cell Therapy via Singlet Oxygen Generation

Sarkar,

Jana

2023

ACS Appl. Nano Mater.

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Ultrasound-based sonodynamic therapy has great potential for the wireless treatment of human diseases that exploit sound-responsive materials such as microbubbles, piezoelectric nanoparticles, and molecular sonosensitizers. Although small molecule-based sonosensitizers are attractive, their performance needs significant improvement, and a clear understanding of the origin of the ultrasound-mediated reactive oxygen species (ROS) generation property is yet to be established. Here, we have investigated molecular sonosensitizer-loaded poly(ethylene glycol)–poly(lactide) (PEG–PLA) micelles to investigate their ROS generation performance in the presence of ultrasound. We found that molecular sonosensitizers produce singlet oxygen as the primary ROS component, and the ROS generation performance depends on the molecular structure and experimental conditions. We propose that sonoluminescence-induced molecular excitation is associated with such ROS generation. The nanocarrier-based cell delivery of a molecular sonosensitizer is shown to generate intracellular ROS under ultrasound exposure and has been used for cell therapy application. This work shows that singlet oxygen is primarily responsible for molecular sonosensitizer-based sonodynamic therapy, and a nanomicelle-based carrier can greatly improve this therapeutic performance.

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Ultrasound responsive self-assembled micelles loaded with hypocrellin for cancer sonodynamic therapy

Cited by 20 publications

References 22 publications

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Nanoscale Micelles Loaded with Fe₃O₄ Nanoparticles for Deep-Tissue Penetration and Ferroptosis/Sonodynamic Tumor Therapy

Molecular Sonosensitizer-Loaded Polymer Nanomicelle for Ultrasound-Based Cell Therapy via Singlet Oxygen Generation

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Ultrasound responsive self-assembled micelles loaded with hypocrellin for cancer sonodynamic therapy

Cited by 20 publications

References 22 publications

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Nanoscale Micelles Loaded with Fe3O4 Nanoparticles for Deep-Tissue Penetration and Ferroptosis/Sonodynamic Tumor Therapy

Molecular Sonosensitizer-Loaded Polymer Nanomicelle for Ultrasound-Based Cell Therapy via Singlet Oxygen Generation

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Nanoscale Micelles Loaded with Fe₃O₄ Nanoparticles for Deep-Tissue Penetration and Ferroptosis/Sonodynamic Tumor Therapy