Ultrasound Scanning: Possibilities and Prospects of Evaluating Lung Involvement in Systemic Scleroderma

Rheumatoid arthritis (RA) is an immune-mediated rheumatic disease (IMRDs) characterized by chronic erosive arthritis and systemic damage to internal organs, leading to early disability and reduced life expectancy in patients. A particularly important place among the systemic manifestations of RA is occupied by interstitial lung diseases (ILD) – the most severe form of pulmonary pathology in RA, defined as RA-ILD, which is pathogenetically associated with risk factors (smoking, etc.) and autoimmune mechanisms underlying RA. RA-ILD is a subtype of RA characterized by a severe course and a poor prognosis и неблагоприятным прогнозом. The review presents new data regarding risk factors and biomarkers for RA-ILD; modern diagnostic capabilities based on the use of functional lung tests, high-resolution computed tomography, ultrasound examination of the lungs. Particular attention is paid to the efficacy and safety of pharmacotherapy, including methotrexate, biologics, JAK inhibitors, and antifibrotic therapy. An algorithm for the pharmacotherapy of RA-ILD has been proposed.

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Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology

Насонов

Ananieva²,

Avdeev

2022

Naučno-praktičeskaâ revmatologiâ

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Use of ultrasound to evaluation interstitial lung disease in rheumatic disease

Ovsyannikova,

Koneva,

Garzanova

et al. 2024

Naučno-praktičeskaâ revmatologiâ

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Interstitial lung disease is one of the most relevant extra-articular manifestations of rheumatic diseases resulting in a substantial increase in morbidity and mortality. Early diagnosis and close monitoring to identify patients at risk of progression are crucial to establish the need for targeted treatment with immunomodulatory and antifibrotic drugs, with potential ability to change the course of the disease. High resolution computed tomography (HRCT) is the standard radiographic technique to diagnose lung involvement in patients suffering from respiratory symptoms or presenting with a pathological pulmonary function test. HRCT is able to detect changes in the lung before they are apparent on conventional X-ray. Recently, sonography of the lung was introduced as a safe and easily available method for detecting lung fibrosis, bronchiolitis or pneumothorax Sonographic signs like tissue B-lines, irregularities of the pleura or the absence of lung sliding might be a suitable screening tool for lung involvement. In this context, lung ultrasound (LUS) is an attractive tool in a growing research and validation process.

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Ultrasound Scanning: Possibilities and Prospects of Evaluating Lung Involvement in Systemic Scleroderma

Cited by 2 publications

References 46 publications

Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology

Interstitial lung disease in rheumatoid arthritis: A multidisciplinary problem in rheumatology and pulmonology

Use of ultrasound to evaluation interstitial lung disease in rheumatic disease

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