Ultrasound shear wave elastography of breast lesions: correlation of anisotropy with clinical and histopathological findings

Chen, Ya Ling; Gao, Yi; Chang, Cai; Wang, Fen; Zeng, Wei; Chen, Jia Jian

doi:10.1186/s40644-018-0144-x

Cited by 35 publications

(18 citation statements)

References 26 publications

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“…Thirdly, only a single view plane has been utilized in this study. It has been shown in previous studies that anisotropy correlates with some prognostic factors in breast cancer [ 40 , 41 ]. Therefore, further prospective comparison studies with larger recruitments are necessary to compare the mean elasticity along the two orthogonal orientations of the shear waves.…”

Section: Discussionmentioning

confidence: 99%

Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses

Polley

Ternifi

et al. 2020

The Breast

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Purpose To investigate the diagnostic role of new metrics, defined as individualized-thresholding of Shear Wave Elastography (SWE) parameters, in association with clinical factors (such as age, mammographic density, lesion size and depth) and the BI-RADS features in differentiating benign from malignant breast lesions. Methods Of 644 consecutive patients (median age, 55 years), prospectively referred for evaluation, 659 ultrasound detected breast lesions underwent SWE measurements. Multivariable logistic regression analysis was used to estimate the probability of malignancy. The area under the curve (AUC), optimal cutoff value, and the corresponding sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were determined. Results 265 of 659 (40.2%) masses were malignant. Using two E mean cutoffs, 69.6 kPa for large superficial lesions (size >10 mm, depth ≤5 mm) and 39.2 kPa for the rest, the overall specificity, sensitivity, PPV and NPV were 92.6%, 86.8%, 88.8% and 91.3%, respectively. Combining multiple factors, including E mean with two cutoffs, age and BI-RADS, the new ROC curve based on the malignancy probability calculation showed the highest AUC (0.954, 95% CI: 0.938–0.969). Using the optimal probability threshold of 0.514, the corresponding specificity, sensitivity, PPV and NPV were 92.9%, 89.1%, 89.4% and 92.7%, respectively. Conclusions The false-positive rate can be significantly reduced when applying two E mean cutoffs based on lesion size and depth. Moreover, the combination of age, E mean with two cutoffs and BI-RADS can further reduce the false negatives and false positives. Overall, this multifactorial analysis improves the specificity of ultrasound while maintaining a high sensitivity.

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Section: Discussionmentioning

confidence: 99%

Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses

Polley

Ternifi

et al. 2020

The Breast

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“…Fortunately, ultrasound SWE has reported to detect differences between healthy and pathological tissues. [ 18 – 23 ] Although several studies explored the association between SWEP and CPC in patients with BC, no systematic review has undertaken this topic. This study will systematically and comprehensively investigate the association between SWEP and CPC in BC.…”

Section: Discussionmentioning

confidence: 99%

“…Studies reported that ultrasound shear wave elastography (SWE) can supply novel insights into the shear elastic modulus of soft tissues. [ 18 – 23 ] It can be used to detect differences between healthy and pathological tissues. [ 18 – 23 ] It is reported that ultrasound SWE has used for the detection of patients with BC.…”

Section: Introductionmentioning

confidence: 99%

“…[ 18 – 23 ] It can be used to detect differences between healthy and pathological tissues. [ 18 – 23 ] It is reported that ultrasound SWE has used for the detection of patients with BC. [ 24 – 26 ] However, no study has performed the association between SWE parameters (SWEPs) and clinicopathological characteristics (CPCs) in BC.…”

Section: Introductionmentioning

confidence: 99%

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Study on association between shear wave elastography parameters and clinicopathological characteristics in breast cancer

Xue

Wang

2020

Medicine

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Background: This study aims to explore the association between shear wave elastography parameters (SWEPs) and clinicopathological characteristics (CPCs) in breast cancer (BC). Methods: The electronic databases of Cochrane Library, MEDLINE, EMBASE, Allied and Complementary Medicine Database, WANGFANG, VIP, and China National Knowledge Infrastructure will be used to search for studies dated from database inception to the present. No limitations of language and publication status will be applied in this study. Only case-controlled study and randomized controlled trials investigating the association between SWEP and CPC in BC will be included. Cochrane risk of bias will be used to assess study quality for each included study. RevMan 5.3 software will be utilized for statistical analysis. Results: This study will provide accurate data to appraise the association between SWEP and CPC in BC. Conclusion: This study will summarize the most recent evidence to improve our understanding of the association between SWEP and CPC in BC. OSF registration number: osf.io/vmkwu.

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“…DtP >15 mm on mammography and ultrasound implies that the lesion is probably malignant. 36 On the other hand, this feature has not been associated with malignancy for shear wave elastography, 37 and there is no literature available regarding DtP in CEUS. In the present study, DtP of malignant lesions (true positive and false negative) was larger than for benign lesions.…”

Section: Discussionmentioning

confidence: 99%

<p>A multicenter study of a contrast-enhanced ultrasound diagnostic classification of breast lesions</p>

Tang

Chen

et al. 2019

CMAR

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PurposeTo evaluate a classification model of contrast-enhanced ultrasound (CEUS) and examine the characteristics of patients with false-negative diagnosis.Patients and methodsA retrospective secondary analysis of a multicenter trial of CEUS for breast cancer diagnosis (from August 2015 to April 2017) was undertaken. Patients (n=1,023) with Breast Imaging Reporting and Data System 4–5 lesions on B-mode ultrasound underwent CEUS. Pathological diagnoses were available from surgical or biopsy specimens for correlation. Lesion maximum diameter (LMD), distance to the papilla (DtP), distance from the superficial edge of the lesion to the skin (DtS), distance from the deep edge of the lesion to the pectoralis muscle (DtPM), and body mass index (BMI) were evaluated.ResultsMedian age and BMI were 48.0 and 41.2 years and 23.2 and 22.4 kg/m2 for patients with malignant and benign lesions, respectively. Overall sensitivity, specificity, and accuracy of CEUS for malignancy were 89.4%, 65.3%, and 75.8%, respectively. The patients with true-positive and false-negative diagnosis (ie, with malignant lesion) were older than those with false-positive and true-negative diagnosis (ie, with benign lesion). Patients with true-positive and false-positive diagnoses had higher BMI than patients with true-negative and false-negative diagnoses (P=0.004). Patients with true-positive and false-negative diagnoses had larger LMD and DtP, as well as smaller DtS and DtPM.ConclusionOlder age, higher BMI, larger LMD and DtP, and smaller DtS and DtPM were associated with malignant lesions on CEUS. Patients with these characteristics should undergo further imaging.

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Ultrasound shear wave elastography of breast lesions: correlation of anisotropy with clinical and histopathological findings

Cited by 35 publications

References 26 publications

Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses

Individualized-thresholding Shear Wave Elastography combined with clinical factors improves specificity in discriminating breast masses

Study on association between shear wave elastography parameters and clinicopathological characteristics in breast cancer

<p>A multicenter study of a contrast-enhanced ultrasound diagnostic classification of breast lesions</p>

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