Ultrasound-Targeted Microbubble Destruction (UTMD) for Localized Drug Delivery into Tumor Tissue

Wischhusen, Jennifer; Padilla, F.

doi:10.1016/j.irbm.2018.11.005

Cited by 56 publications

(35 citation statements)

References 42 publications

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“…Recently it was reported about the importance of using ultrasound-targeted microbubble destruction technique (UTMD) to induce a transient and reversible BBB disruption, which greatly simplifies intracerebral drug delivery (Wischhusen and Padilla, 2019). In this technique gas bubbles, activated from ultrasounds cause biophysical shock effects that can permeate biological barriers (Wischhusen and Padilla, 2019). A smart "all-in-one" nanosensitizer platform was developed by uniting sonoactive chlorine c6 (Ce6) and HCQ into angiopep2-peptidefunctionalized liposomes (ACHL).…”

Section: Liposomes As An Alternative Strategy Against Autophagy-relatmentioning

confidence: 99%

The Exploitation of Liposomes in the Inhibition of Autophagy to Defeat Drug Resistance

Condello¹,

Mancini

Meschini³

2020

Front. Pharmacol.

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Autophagy is a mechanism involved in many human diseases and in cancers can have a cytotoxic/cytostatic or protective action, being in the latter case involved in multidrug resistance. Understanding which of these roles autophagy has in cancer is thus fundamental for therapeutical decisions because it permits to optimize the therapeutical approach by activating or inhibiting autophagy according to the progression of the disease. However, a serious drawback of cancer treatment is often the scarce availability of drugs and autophagy modulators at the sites of interest. In the recent years, several nanocarriers have been developed and investigated to improve the solubility, bioavailability, controlled release of therapeutics and increase their cytotoxic effect on cancer cell. Here we have reviewed only liposomes as carriers of chemotherapeutics and autophagy inhibitors because they have low toxicity and immunogenicity and they are biodegradable and versatile. In this review after the analysis of the dual role of autophagy, of the main autophagic pathways, and of the role of autophagy in multidrug resistance, we will focus on the most effective liposomal formulations, thus highlighting the great potential of these targeting systems to defeat cancer diseases.

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Section: Liposomes As An Alternative Strategy Against Autophagy-relatmentioning

confidence: 99%

The Exploitation of Liposomes in the Inhibition of Autophagy to Defeat Drug Resistance

Condello¹,

Mancini

Meschini³

2020

Front. Pharmacol.

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“…Other studies have provided evidence that ADV may be initiated by mechanical effects such as acoustic cavitation [38]. The mechanical effects such as microstreaming, liquid jet, and shock wave produced by cavitation may impinge on the surface of droplets and induce vaporization [45,47]. However, more studies have shown that phase transition can be induced independently of inertial acoustic cavitation [15,44].…”

Section: Acoustic Droplet Vaporization (Adv)mentioning

confidence: 99%

“…Ultrasonic cavitation at the histological interface can widen the gap between surrounding target cells (including vascular endothelial cells and tissue cells), facilitate cell endocytosis, form transient pores at cell surface (acoustic pore effect), and produce reactive oxygen species (ROS) (Fig. 3), which can serve as a driving force to facilitate the delivery of drugs or genes from the microbubbles into the target cells [47].…”

Section: Application Of Nds On Targeted Therapy Of Tumormentioning

confidence: 99%

“…When exposed to targeted ultrasound insonation, these NDs are converted into microbubbles in tumor sites. Through the ultrasound-targeted microbubble destruction (UTMD) effect [47,57], the microbubbles cavitate and collapse to release the encapsulated drug and dramatically enhance intracellular drug uptake by the tumor cells [10]. NDmediated enhanced tumor chemotherapy can reduce the side effects of drugs and improve treatment efficacy and patient tolerance.…”

Section: Nd-mediated Enhanced Tumor Chemotherapymentioning

confidence: 99%

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Advances in Targeted Tumor Diagnosis and Therapy Based on Ultrasound-Responsive Nanodroplets

Li¹,

Liu²,

Duan³

et al. 2020

Advanced Ultrasound in Diagnosis and Therapy

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The ultrasound contrast agents currently used in clinics are microbubbles with a large particle size and short circulation time, and their approved clinical applications are limited to endovascular diagnosis and therapy only. The development of ultrasound-responsive nanodroplets (NDs) provides a new approach for extravascular diagnosis and therapy, especially for molecular imaging and targeted therapy of tumors. The NDs with a nano-scaled particle size and a liquid core can maintain their shape and initial diameter during injection, enhancing their EPR effects and facilitating the accumulation of NDs at the tumor site. When exposed to ultrasound, NDs can vaporize and exhibit contrast enhancement at the sites of interest. In addition, the destruction of microbubbles can provide a driving force to facilitate the release of drugs or genes from the microbubbles into target cells, allowing the NDs to act as drug carriers. The development of ultrasound-responsive NDs has shown rapid progress in recent years, while a variety of NDs with excellent properties have been fabricated for targeted diagnosis and drug delivery. In this article, the development of ultrasound-responsive NDs was reviewed in terms of their structure, phase transition properties, and applications in targeted tumor diagnosis and therapy.

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“…However, more recently, attention has shifted to much smaller bubbles, having diameters of micro or even nanometers 20‐23 . Microbubbles are increasingly used in innovative applications such as the targeted delivery of drugs and anti‐tumor medicines in the human body 24,25 . Other major interests are in relation to the aeration and treatment of waste water, 26,27 and the reduction of drag on immersed bodies by the release of microbubbles near the solid surface 22,28 .…”

Section: Introductionmentioning

confidence: 99%

Computational modeling of microbubble coalescence and breakup using large eddy simulation and Lagrangian tracking

et al. 2020

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The flow of dispersed microbubbles was studied with an Eulerian-Lagrangian technique using large eddy simulation to predict the continuous liquid flow and Lagrangian tracking to compute bubble trajectories. The model fully accounts for bubble coalescence and breakup and was applied to horizontal and vertical channel flows. With low levels of turbulence, gravity in horizontal, and lift in vertical, channel flows govern the bubble spatial and collision distribution. When turbulence is sufficiently high to, at least partially, oppose bubble preferential concentration, more uniform collision and coalescence distributions are found, although these remain peaked near the wall in both configurations. Almost 100% coalescence efficiency was always found, due to bubbles colliding along similar trajectories, with breakup only recorded in a flow of low surface tension refrigerant R134a. Models like this can provide the required quantitative understanding of the microbubbles complex behavior, as well as supporting the development of more macroscopic modeling closures.

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Ultrasound-Targeted Microbubble Destruction (UTMD) for Localized Drug Delivery into Tumor Tissue

Cited by 56 publications

References 42 publications

The Exploitation of Liposomes in the Inhibition of Autophagy to Defeat Drug Resistance

The Exploitation of Liposomes in the Inhibition of Autophagy to Defeat Drug Resistance

Advances in Targeted Tumor Diagnosis and Therapy Based on Ultrasound-Responsive Nanodroplets

Computational modeling of microbubble coalescence and breakup using large eddy simulation and Lagrangian tracking

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