Ultrasound Tomography of Excised Brains: Normal and Pathological Anatomy

Patrick, James T.; Fry, F. J.; Gardner, Glenn P.; Franklin, Thomas D.; Muller, Jans; Heimburger, Robert F.

doi:10.1007/978-1-4613-4021-8_74

Cited by 2 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neuroimaging emerged as a diagnostic tool in the mid-1970s with cranial ultrasonography (US) to assess intracranial hemorrhage in neonates [ 19 ]. In 1978, Dr. Volpe indicated that one of the primary goals of neuroimaging in preterm infants was to “identify those with a hopeless prognosis” [ 20 ].…”

Section: History Of Neuroimaging and Patterns Of Brain Injury In Tmentioning

confidence: 99%

Neuroimaging at Term Equivalent Age: Is There Value for the Preterm Infant? A Narrative Summary

et al. 2021

View full text Add to dashboard Cite

Advances in neuroimaging of the preterm infant have enhanced the ability to detect brain injury. This added information has been a blessing and a curse. Neuroimaging, particularly with magnetic resonance imaging, has provided greater insight into the patterns of injury and specific vulnerabilities. It has also provided a better understanding of the microscopic and functional impacts of subtle and significant injuries. While the ability to detect injury is important and irresistible, the evidence for how these injuries link to specific long-term outcomes is less clear. In addition, the impact on parents can be profound. This narrative summary will review the history and current state of brain imaging, focusing on magnetic resonance imaging in the preterm population and the current state of the evidence for how these patterns relate to long-term outcomes.

show abstract

Section: History Of Neuroimaging and Patterns Of Brain Injury In Tmentioning

confidence: 99%

Neuroimaging at Term Equivalent Age: Is There Value for the Preterm Infant? A Narrative Summary

et al. 2021

View full text Add to dashboard Cite

show abstract

“…interstitial brachytherapy (49,75), interstitial (71,85,91), and non-invasive methods of hyperthermia (18,19,94), CT-guided laser destruction (60)(61)(62), stereotactic radiosurgery (67), CT-guided and assisted surgical removal of tumors (93)] there is a basic need to thoroughly assess the accuracy of imaging modalities in defining tumor boundaries. Relatively few studies have compared the neuropathological extent of human (24,53,56,74) or spontaneous and experimental animal (40,46,59,66,84) brain tumors with the extent depicted on CT. Less work has been performed in correlating the neuropathological extent of brain tumors with HRUS images (80).…”

Section: Introductionmentioning

confidence: 99%

Correlation of neuropathologic findings, computerized tomographic and high-resolution ultrasound scans of canine avian sarcoma virus-induced brain tumors

et al. 1987

View full text Add to dashboard Cite

The location, size, geometry and neuropathological findings of anaplastic astrocytomas (AA), gliosarcomas and sarcomas induced by the avian sarcoma virus (ASV) in dogs were compared with images generated using computerized tomography (CT) and real time high-resolution ultrasound (HRUS). Seven AA showed a wide range of findings on CT. Pre-contrast CT scans showed that the tumors could be hyper, hypo, or isodense. Three of seven AA had no contrast enhancement; two of these tumors were also isodense which resulted in a false-negative CT exam. Partial enhancement was seen in one tumor. This resulted in a sensitivity of detection of 72%. Real time HRUS was able to define tumor location, size and geometry of the AA missed or incompletely imaged by CT. All tumors were hyperechoic. Inhomogeneity of the echo pattern was due to hemorrhage, cyst formation, and necrosis within the tumors. Such secondary tumor characteristics were more accurately defined by HRUS compared to CT. Vasogenic edema in the brain surrounding tumors was of low density on CT and hypoechoic or indistinguishable from normal brain on US. Similar findings were seen in six gliosarcomas, two of which were not visualized by either pre- or post-contrast enhanced CT scans (sensitivity of 66%). Sarcomas differed in that they were either hyper or isodense; none were hypodense. The area of increased density matched the tumor geometry and correlated with dense cellularity and reticulin deposition. All 13 sarcomas showed contrast enhancement (100% sensitivity), but in two tumors, contrast enhanced CT underestimated the size of the tumor. Because of the large size and multiplicity of the sarcomas, HRUS imaging was not able to resolve the entire tumor volume because of limited imaging access. Intravenously injected horseradish peroxidase (HRP) crossed the tumor blood-brain barrier (BBB) only in those tumors in which contrast enhancement was seen. These studies suggest that intraoperative HRUS imaging may be useful in detecting and delineating human AA incompletely visualized by CT.

show abstract

Ultrasound Tomography of Excised Brains: Normal and Pathological Anatomy

Cited by 2 publications

References 7 publications

Neuroimaging at Term Equivalent Age: Is There Value for the Preterm Infant? A Narrative Summary

Neuroimaging at Term Equivalent Age: Is There Value for the Preterm Infant? A Narrative Summary

Correlation of neuropathologic findings, computerized tomographic and high-resolution ultrasound scans of canine avian sarcoma virus-induced brain tumors

Contact Info

Product

Resources

About