Ultrasound treatment for accelerating fracture healing of the distal radius. A control study

Liu, Yinwen; Wei, Xiaoen; Kuang, Yong; Zheng, Yuxin; Gu, Xuefan; Zhan, Hongsheng; Shi, Yingying

doi:10.1590/s0102-86502014001800012

Cited by 23 publications

(28 citation statements)

References 27 publications

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“…The LIPUS treatment was used for 20 minutes a day except in 2 trials. [ 48 , 58 ] In one of these trials, [ 48 ] the LIPUS treatment was used for 15 minutes every day, and in the other one, [ 58 ] the LIPUS treatment was used 2 times a day for 20 minutes each. All of the included studies demonstrated good compliance with the LIPUS treatment.…”

Section: Resultsmentioning

confidence: 99%

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The effects of low-intensity pulsed ultrasound on fresh fracture

Lou

et al. 2017

Medicine

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Section: Resultsmentioning

confidence: 99%

“…For the included trials, 5 trials [ 48 , 50 , 54 , 56 , 57 ] used the conservative treatment, and the conservative treatment for these 5 trials used plaster of Paris to maintain reduction. The plaster was not removed when LIPUS was used.…”

Section: Resultsmentioning

confidence: 99%

The effects of low-intensity pulsed ultrasound on fresh fracture

Lou

et al. 2017

Medicine

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“…19 20 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 Two trials, Handolin and colleagues32 33 and Emami and colleagues,29 30 provided two publications reporting on the same group of patients. There were no shared patients between the TRUST pilot26 and the definitive trial 16.…”

Section: Resultsmentioning

confidence: 99%

“…All but two trials applied LIPUS for 20 minutes every day, either for a fixed period or until radiographic healing. Otherwise, one trial applied LIPUS for 15 minutes a day,36 and another trial for five minutes every second day 39. Fifteen trials (60%) provided their control group with an inactive device that was indistinguishable from the active LIPUS.…”

Section: Resultsmentioning

confidence: 99%

Low intensity pulsed ultrasound for bone healing: systematic review of randomized controlled trials

Schandelmaier

Kaushal

Lytvyn

et al. 2017

BMJ

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Objective To determine the efficacy of low intensity pulsed ultrasound (LIPUS) for healing of fracture or osteotomy.Design Systematic review and meta-analysis.Data sources Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials, and trial registries up to November 2016.Study selection Randomized controlled trials of LIPUS compared with sham device or no device in patients with any kind of fracture or osteotomy.Review methods Two independent reviewers identified studies, extracted data, and assessed risk of bias. A parallel guideline committee (BMJ Rapid Recommendation) provided input on the design and interpretation of the systematic review, including selection of outcomes important to patients. The GRADE system was used to assess the quality of evidence.Results 26 randomized controlled trials with a median sample size of 30 (range 8-501) were included. The most trustworthy evidence came from four trials at low risk of bias that included patients with tibia or clavicle fractures. Compared with control, LIPUS did not reduce time to return to work (percentage difference: 2.7% later with LIPUS, 95% confidence interval 7.7% earlier to 14.3% later; moderate certainty) or the number of subsequent operations (risk ratio 0.80, 95% confidence interval 0.55 to 1.16; moderate certainty). For pain, days to weight bearing, and radiographic healing, effects varied substantially among studies. For all three outcomes, trials at low risk of bias failed to show a benefit with LIPUS, while trials at high risk of bias suggested a benefit (interaction P<0.001). When only trials at low risk of bias trials were considered, LIPUS did not reduce days to weight bearing (4.8% later, 4.0% earlier to 14.4% later; high certainty), pain at four to six weeks (mean difference on 0-100 visual analogue scale: 0.93 lower, 2.51 lower to 0.64 higher; high certainty), and days to radiographic healing (1.7% earlier, 11.2% earlier to 8.8% later; moderate certainty).Conclusions Based on moderate to high quality evidence from studies in patients with fresh fracture, LIPUS does not improve outcomes important to patients and probably has no effect on radiographic bone healing. The applicability to other types of fracture or osteotomy is open to debate.Systematic review registration PROSPERO CRD42016050965

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“…Nolte et al demonstrated that the healing rate for metatarsal fractures in patients treated with low‐intensity pulsed US was significantly faster than the healing rate for matched patients who were not treated. Liu et al found that low‐intensity pulsed US could promote fracture healing of the distal radius and promote local bone formation. Patel et al investigated the effects of low‐intensity pulsed US on the healing of mandibular fractures, and they found a significant improvement in radiographic density in the low‐intensity pulsed US treatment group compared to the control group.…”

Section: Discussionmentioning

confidence: 99%