Ultrasound triggered, image guided, local drug delivery

Deckers, Roel; Moonen, Chrit

doi:10.1016/j.jconrel.2010.07.117

Cited by 169 publications

(122 citation statements)

References 103 publications

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“…The drugs loaded on temperature sensitive liposomes were rapidly released in the target region by thermal effects of ultrasound at physiologically temperatures as a result of heating to generate a transition of the phospholipid membrane from a gel to a fluid [68][69][70][71]. In addition, the PFC nanoparticles encapsulated doxorubicin in combination with RF ablation have been receiving clinical trials [69,72].…”

Section: The Machanism Of Pfc Nanoparticles For Ultrasound Theranostimentioning

confidence: 99%

“…On the one hand, the inertial cavitation of microbubbles grown and collapsed by mechanical force in the ultrasound field can produce shock waves and microjets that can create pores in cell membranes and blood vessels thereby accelerating the permeability of genes, drugs, and their carriers [71,79,80]. This phenomenon that inertial cavitation results in creation of cavities in cell membranes is called sonoporation [81,82].…”

Section: Mechanical Action Of Cavitationmentioning

confidence: 99%

See 1 more Smart Citation

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Xu¹,

Cao²,

Xu³

et al. 2015

Nano BioMed ENG

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Recently, the advances in perfluorocarbon nanoparticles have been introduced to expand the diagnostic and therapeutic capability of ultrasound molecular imaging, a non-invasive diagnostic imaging, which passed from robust anatomical presentation to detection of physiological processes and recognition of specific tissue epitopes at the cellular level. The good properties of perfluorocarbon nanoparticles, such as nontoxicity, small size, phase-shift capability, etc., have been resulted in tremendous potential prospects in clinical application. Herein, this review focuses on the mechanisms of perfluorocarbon nanoparticles in terms of phase transition and ultrasonic theranostic. And the potential applications of perfluorocarbon nanoparticles in ultrasound medicine are also discussed.

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Section: The Machanism Of Pfc Nanoparticles For Ultrasound Theranostimentioning

confidence: 99%

Section: Mechanical Action Of Cavitationmentioning

confidence: 99%

Phase-transition Perfluorocarbon Nanoparticles for Ultrasound Molecular Imaging and Therapy

Xu¹,

Cao²,

Xu³

et al. 2015

Nano BioMed ENG

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“…Enhancement of ultrasound effects using gas microbubbles Particular success in ultrasound mediated drug delivery has been achieved with the use of gas microbubbles [102][103][104][105]. The disparity in acoustic properties between the gas and surrounding media present several opportunities to augment the effects of ultrasound alone.…”

Section: Study Of Drug-cell Interactionmentioning

confidence: 99%

Ultrasound assisted particle and cell manipulation on-chip

Mulvana

Cochran

Hill

2013

Advanced Drug Delivery Reviews

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Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.

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“…Networks containing gas-filled microbubbles are also suitable systems to be disrupted applying ultrasounds [118]. Furthermore, ultrasound imaging enables the monitoring of the therapy [119].…”

Section: Ultrasoundsmentioning

confidence: 99%