Ultrasound-triggered nicotine release from nicotine-loaded cellulose hydrogel

Ultrasound-Triggered Amoxicillin Release from Chitosan/Ethylene Glycol Diglycidyl Ether/Amoxicillin Hydrogels Having a Covalently Bonded Network

“…A comparison of the water content in Table 1 and postultrasonic irradiation values showed a slight increase in water retention with US irradiation. A similar trend was observed for cellulose hydrogels 44 and chitin hydrogels. 25 This trend was evident for the flexible 1.5 and 2% CS/EGDE/ Amox, but not for the rigid hydrogel, 3% CS/EGDE/Amox; on the contrary, the moisture content decreased.…”

“…The Amox amounts entrapped in the hydrogels were determined according to a previous technique with a few modifications. 44 To do this successfully, the Amox-entrapped hydrogel was sliced into small pieces and placed into 15 mL of distilled water under stirring for 2, 24, and 48 h at room temperature, allowing the entrapped Amox to escape into the aqueous medium. The experiment was repeated separately for three specimens to ensure repeatability.…”

“…The change of strain % at G′ = G″ was also greater for the cellulose hydrogels. 44,51 In the case of cellulose hydrogels, gelation was mainly due to hydrogen bonding and entanglement of the molecular chains, but no covalent cross-linking like CS/EGDE. In the cellulose hydrogel, hydrogen bond disruption contributed to the softening of the gel due to a decrease in viscoelasticity.…”

Advances in ultrasound-responsive hydrogels for biomedical applications

“…Hydrogels with excellent biocompatibility, biodegradability, low toxicity, high drug loading and strong drug encapsulation can be widely used in drug delivery. [87][88][89][90] In particular, it is worth emphasizing that the injectable, self-healing hydrogel drug carrier formed by physical cross-linking has good cell permeability, can be targeted for injection, and can reach tiny defects deep in the tissue, showing superior application prospects. 91,92 Ultrasound has been used in medical treatment for many years.…”

Ultrasound Viscoelastic Properties of Biomass Polysaccharide Hydrogels as Evaluated by Rheometer Equipped with Sono-Device

“…By contrast, weaker US disconnects hydrogen bonding in soft microgel polymers [ 22 ] and significantly decreases the polymeric aqueous solution viscosity [ 23 ] and polyacrylic acid–silica slurry [ 24 ] by breaking hydrogen bonds linking the polymeric chains. In addition to such aqueous polymer media, a polymeric hydrogel matrix made of cellulose [ 25 ] and chitin [ 26 ] contains large amounts of water and displays triggered properties efficiently under mild US exposure without cavitation influence, thereby indicating that US stress can destroy hydrogen bond networks in polymeric hydrogels. In such a biomass polymer, the hydrogels are safe and reliable materials, suitable for practical applications when used as a US-triggered matrix in medical and food-related fields.…”