Ultrasound-Triggered On-Demand Insulin Release for Diabetes Mellitus Treatment

Bao, Hongyi; Chen, Jingru; Wang, Xiaoping; Chen, Chao; Gong, Jinke; Liu, Jun; Xia, Daohong

doi:10.1007/s10439-022-02994-1

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…Chemotherapeutic agents can be transported to the tumor and be passively released in the presence of external forces, such as laser, ultrasound, and low pH. [26][27][28] Several differences that exist between normal and tumor-derived blood vessels, such as extensive angiogenesis and vascular permeability, would facilitate drug retention. Targeting agents that interact with a cell surface antigen or receptor to deliver the nanocarrier intracellularly are considered as active targeting.…”

Section: Erythrocyte and Their Membrane-loaded Drug Carriersmentioning

confidence: 99%

Section: Erythrocyte-loaded Drug Carriersmentioning

confidence: 99%

mentioning

confidence: 99%

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Advances in Targeting Drug Biological Carriers for Enhancing Tumor Therapy Efficacy

Xia

Jia

Feng

et al. 2023

Macromolecular Bioscience

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Chemotherapy drugs continue to be the main component of oncology treatment research and have been proven to be the main treatment modality in tumor therapy. However, the poor delivery efficiency of cancer therapeutic drugs and their potential off‐target toxicity significantly limit their effectiveness and extensive application. The recent integration of biological carriers and functional agents is expected to camouflage synthetic biomimetic nanoparticles for targeted delivery. The promising candidates, including but not limited to red blood cells and their membranes, platelets, tumor cell membrane, bacteria, immune cell membrane, and hybrid membrane are typical representatives of biological carriers because of their excellent biocompatibility and biodegradability. Biological carriers are widely used to deliver chemotherapy drugs to improve the effectiveness of drug delivery and therapeutic efficacy in vivo, and tremendous progress is made in this field. This review summarizes recent developments in biological vectors as targeted drug delivery systems based on microenvironmental stimuli‐responsive release, thus highlighting the potential applications of target drug biological carriers. The review also discusses the possibility of clinical translation, as well as the exploitation trend of these target drug biological carriers.

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Section: Erythrocyte and Their Membrane-loaded Drug Carriersmentioning

confidence: 99%

Section: Erythrocyte-loaded Drug Carriersmentioning

confidence: 99%