Ultrasound Versus Landmark-Based Technique for Ilioinguinal-Iliohypogastric Nerve Blockade in Children: The Implications on Plasma Levels of Ropivacaine

Abstract

The pharmacokinetic data indicate faster absorption and higher maximal plasma concentration of LA when ultrasound was used as a guidance technique for INB compared with the landmark-based technique. Thus, a reduction of the volume of LA should be considered when using an ultrasound-guided technique for INB.

Pharmacokinetics of the local anesthetic ropivacaine after transversus abdominis plane block in healthy volunteers

“…Microdialysis probes were removed at the end of the experiment. Quantitative ropivacaine assay Ropivacaine concentrations in venous plasma were determined by high-performance liquid chromatography (HPLC) with ultraviolet detection using essentially the procedures as those reported earlier [14]. Briefly, 100 μl of plasma was mixed with 50 μl of chlorzoxazone in water (internal standard) and extracted with 50 μl 1 M Na 2 Co 3 plus tertiary butylmethylether.…”

Ultrasound Imaging for Pediatric Anesthesia: A Review

“…The authors also believe using lower volumes could reduce the risk of local anesthetic toxicity . The use of lower volumes of local anesthetic is also supported by a recent pharmacokinetic study that found higher plasma levels of ropivacaine using ultrasound guidance when compared to a single pop technique (Weintraud et al, 2009). …”

Untitled

“…In all these studies, the authors used single "pop" sensation techniques, injecting local anesthetics under external oblique muscle aponeurosis, with failure rates ranging from 25.8% to 33% [31,1,2,28,30]. In Kundra's study, injection of the local anesthetics above and below internal oblique muscle aponeurosis demonstrate a success rate of 94% [29].…”