Ultrasound waves in tumors via needle irradiation for precise medicine

Abstract

Grounded in the interdisciplinary crosstalk among physics and biological sciences, precision medicine-based diagnosis and treatment strategies have recently gained great attention for the actual applicability of new engineered approaches in many medical fields, particularly in oncology. Within this framework, the use of ultrasounds employed to attack cancer cells in tumors to induce possible mechanical damage at different scales has received growing attention from scholars and scientists worldwide. With these considerations in mind, on the basis of ad hoc elastodynamic solutions and numerical simulations, we propose a pilot study for in silico modeling of the propagation of ultrasound waves inside tissues, with the aim of selecting proper frequencies and powers to be irradiated locally through a new teragnostic platform based on Lab-on-Fiber technology, baptized as a hospital in the needle and already the object of a patent. It is felt that the outcomes and the related biophysical insights gained from the analyses could pave the way for envisaging new integrated diagnostic and therapeutic approaches that might play a central role in future applications of precise medicine, starting from the growing synergy among physics, engineering and biology.

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Innovative Photonic Sensors for Safety and Security, Part II: Aerospace and Submarine Applications

“…Photonic sensing technologies and optical fiber sensors are increasingly being used in new and emerging sectors for a variety of measurement and monitoring applications. Our multidisciplinary group has been active in this field for the last twenty years, concentrating most of our attention on the usage of photonics and nanophotonics [1][2][3][4][5][6][7][8][9][10] for both medical and industrial applications [11][12][13][14][15][16][17][18][19][20], by which we have realized a large variety of in-field applications [21][22][23][24][25][26][27][28][29][30][31][32], some of which have reached the market or are operative in some industrial or research plants (e.g., CERN, Geneve, railways, and aerospace) [33][34][35][36][37][38][39][40][41][42][43][44][45][46]…”

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“…Our multidisciplinary group has been active in this field for the last twenty years, concentrating most of our attention on the usage of photonics and nanophotonics [19][20][21][22][23][24][25][26][27][28] for both medical and industrial applications [29][30][31][32][33][34][35][36][37][38], by which we have realized a large variety of in-field applications [39][40][41][42][43][44][45][46][47][48][49][50], some of which have reached the market or are operative in some industrial or research plants (e.g., CERN, Geneve, railways) [51][52][53][54][55][56][57][58][59][60][61][62][63].…”