Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency

Wang, Wei; Hu, Ziwei; Mo, Wanying; Ouyang, Min; Lin, Shihao; Li, Xiang; Wang, Chengxinqiao; Yu, Feng; Wang, Yupeng; Zhou, Dongfang

doi:10.1016/j.engreg.2024.01.001

Engineered Regeneration

2024

DOI: 10.1016/j.engreg.2024.01.001

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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency

Wei Wang,

Ziwei Hu,

Wanying Mo

et al.

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2024

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Cited by 6 publications

(1 citation statement)

References 58 publications

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“…Consequently, they can result in inadequate biomechanical repair and postoperation failure . To address the issue of poor regenerative characteristics, chemical modifications, such as mRNA, nanomolecular medicines, and various active components such as liposomes are introduced into the biological scaffold. − Nevertheless, due to challenges such as biosafety, packaging efficiency, and difficulties in clinical application, chemical modification is not the most effective way to achieve reliable tendon regeneration.…”

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confidence: 99%

Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration

Yang,

Xu,

et al. 2024

Nano Lett.

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Inspired by the imbalance between extrinsic and intrinsic tendon healing, this study fabricated a new biofilter scaffold with a hierarchical structure based on a melt electrowriting technique. The outer multilayered fibrous structure with connected porous characteristics provides a novel passageway for vascularization and isolates the penetration of scar fibers, which can be referred to as a biofilter process. In vitro experiments found that the porous architecture in the outer layer can effectively prevent cell infiltration, whereas the aligned fibers in the inner layer can promote cell recruitment and growth, as well as the expression of tendon-associated proteins in a simulated friction condition. It was shown in vivo that the biofilter process could promote tendon healing and reduce scar invasion. Herein, this novel strategy indicates great potential to design new biomaterials for balancing extrinsic and intrinsic healing and realizing scarless tendon healing.

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confidence: 99%

Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration

Yang,

Xu,

et al. 2024

Nano Lett.

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Extracellular Vesicle‐Inspired Therapeutic Strategies for the COVID‐19

Hu,

Wang,

Lin

et al. 2024

Adv Healthcare Materials

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Emerging infectious diseases like coronavirus pneumonia (COVID‐19) present significant challenges to global health, extensively affecting both human society and the economy. Extracellular vesicles (EVs) have demonstrated remarkable potential as crucial biomedical tools for COVID‐19 diagnosis and treatment. However, due to limitations in the performance and titer of natural vesicles, their clinical use remains limited. Nonetheless, EV‐inspired strategies are gaining increasing attention. Notably, biomimetic vesicles, inspired by EVs, possess specific receptors that can act as “Trojan horses,” preventing the virus from infecting host cells. Genetic engineering can enhance these vesicles by enabling them to carry more receptors, significantly increasing their specificity for absorbing the novel coronavirus. Additionally, biomimetic vesicles inherit numerous cytokine receptors from parent cells, allowing them to effectively mitigate the “cytokine storm” by adsorbing pro‐inflammatory cytokines. Overall, this EV‐inspired strategy offers new avenues for the treatment of emerging infectious diseases. Herein, this review systematically summarizes the current applications of EV‐inspired strategies in the diagnosis and treatment of COVID‐19. The current status and challenges associated with the clinical implementation of EV‐inspired strategies are also discussed. The goal of this review is to provide new insights into the design of EV‐inspired strategies and expand their application in combating emerging infectious diseases.

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Intelligent bacteria‐targeting ZIF‐8 composite for fluorescence imaging‐guided photodynamic therapy of drug‐resistant superbug infections and burn wound healing

Li,

Wang,

Gao

et al. 2024

Exploration

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Infected burn wounds are characterized by persistent drug‐resistant bacterial infection coupled with an inflammatory response, impeding the wound‐healing process. In this study, an intelligent nanoparticle system (CCM+TTD@ZIF‐8 NPs) was prepared using curcumin (CCM), an aggregation‐induced emission luminogens (TTD), and ZIF‐8 for infection‐induced wound healing. The CCM+TTD@ZIF‐8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging and pH response‐guided photodynamic therapy (PDT), and anti‐inflammatory. The positive charges of ZIF‐8 NPs allowed the targeting of drug‐resistant bacteria in infected wounds, thereby realizing fluorescence imaging of bacteria by emitting red fluorescence at the infected site upon blue light irradiation. The pH‐responsive characteristics of the CCM+TTD@ZIF‐8 NPs also enabled controllable CCM release onto the infected wound site, thereby promoting the specific accumulation of ROS at the infected site, with outstanding bactericidal efficacy against drug‐resistant Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) strains in vitro/in vivo. Additionally, due to the excellent bactericidal effect and anti‐inflammatory properties of CCM+TTD@ZIF‐8 NPs combined with blue light irradiation, the regeneration of epidermal tissue, angiogenesis, and collagen deposition was achieved, accelerating the healing process of infected burn wounds. Therefore, this CCM+TTD@ZIF‐8 NPs with multifunctional properties provides great potential for infected burn wound healing.

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Ultrastable in-situ silver nanoparticle dressing for effective prevention and treatment of wound infection in emergency

Cited by 6 publications

References 58 publications

Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration

Synergistic Biofilter Tube for Promoting Scarless Tendon Regeneration

Extracellular Vesicle‐Inspired Therapeutic Strategies for the COVID‐19

Intelligent bacteria‐targeting ZIF‐8 composite for fluorescence imaging‐guided photodynamic therapy of drug‐resistant superbug infections and burn wound healing

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