Ultrastructural analysis of a local regulation of Leydig cells in the adult monkey (Macaca fascicularis) and rat

Fouquet, J

doi:10.1530/jrf.0.0790049

Cited by 11 publications

(2 citation statements)

References 22 publications

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“…Tissue preparation. -As previously described (Fouquet et al, 1984 ;Fouquet, 1987) (Christensen, 1975 Anderson, 1959) and in young mice (Baillie, 1961 ;Hitzeman, 1962) Kormano, 1964 ;Okada, 1970), whereas no labeling was detected at the same age (1 to 21 days) in semi-thin plastic sections (Orth, 1982). these different results might be related to preparative methods but more probably to Leydig cell identification which was more reliable in the latter work.…”

Section: Introductionmentioning

confidence: 66%

Mitotic activity in monkey and rat Leydig cells

Fouquet¹,

Kann²

1987

Reprod. Nutr. Dévelop.

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Section: Introductionmentioning

confidence: 66%

Mitotic activity in monkey and rat Leydig cells

Fouquet¹,

Kann²

1987

Reprod. Nutr. Dévelop.

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“…In favor of a regulatory role of seminiferous tubules on Leydig cells morphology and probably function is also the obser vation that, in the rat, Leydig cells lying close to stage VII-VIII seminiferous tubules were larger than those lying adjacent to tubules at other stages or adjacent to vessels. Although in a subsequent study in rats and mon keys [78] these variations in size of Leydig cells associ ated with stages of seminiferous tubules were not ob served. a hypertrophy of the smooth endoplasmic reticu lum in Leydig cells adjacent to stage VII tubules in the rat was observed.…”

Section: Leydig-sertoli Cell Interactionsmentioning

confidence: 83%

Cell-Cell Communication in the Testis

Saez¹,

Avallet²,

Lejeune³

et al. 1991

Horm Res

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In addition to the well-established endocrine regulation of testicular functions by gonadotropins, many data accumulated in the last few years indicate that a local control is required for a normal production of androgens and spermatogenesis. In the present paper we review the cell-cell interactions between somatic and germ cells in the testis and their role on the function of each cell type. Also, we will present evidences indicating that some of these interactions are mediated by several growth factors produced and acting within the testis. Moreover, very often the production of these factors are under control of gonadotropins, and in turn the growth factors regulate the sensitivity of testicular cells to these hormones.

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Effects of Hypophysectomy and Alterations in Spermatogenic Function on Leydig Cell Volume, Number, and Proliferation in Adult Rats

KEENEY,

EWING

1990

Journal of Andrology

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The two major objectives of this study were to determine (i) whether the pituitary is required to maintain Leydig cell number per testis, and (ii) whether alterations in spermatogenic function in the absence of LH can affect Leydig cell volume, number, and 3H‐thymidine incorporation in vivo. Four experimental treatments tested the combinations of two factors: (i) the intact pituitary vs hypophysectomy (Hypox); and (ii) arrested vs active spermatogenesis. Subdermal Silastic capsules were used to deliver a low dosage of estradiol in addition to a low dosage of testosterone (TE), which arrested spermatogenesis, or a high dosage of testosterone (HTE) which maintained active spermatogenesis. All four treatments (TE, HTE, Hypox and Hypox‐HTE) inhibited LH secretion for 16 weeks. Control rats were sham hypophysectomized. Leydig cell volume per testis and the volume of an average Leydig cell decreased 70–85% (P < 0.01 vs controls) in all treated rats, whether deprived of LH (TE) or of all pituitary secretions (Hypox), and whether spermatogenesis was arrested (TE, Hypox) or maintained by exogenous testosterone (HTE, Hypox‐HTE). This result suggested that LH was the only factor required to maintain Leydig cell volume, since the absence of other pituitary factors or alterations in spermatogenic function could not override or modify the effect of LH deprivation. No significant differences were found in Leydig cell number per testis or the proportion of Leydig cells labeled with 3H‐thymidine among control and experimentally treated rats. In contrast to Leydig cell volume, which depended on LH, Leydig cell number and Leydig cell division were maintained at control values in the absence of pituitary factors and spermatogenic function for 16 weeks.

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Ultrastructural analysis of a local regulation of Leydig cells in the adult monkey (Macaca fascicularis) and rat

Cited by 11 publications

References 22 publications

Mitotic activity in monkey and rat Leydig cells

Mitotic activity in monkey and rat Leydig cells

Cell-Cell Communication in the Testis

Effects of Hypophysectomy and Alterations in Spermatogenic Function on Leydig Cell Volume, Number, and Proliferation in Adult Rats

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