Ultrastructural and histochemical observations on microcalculi in chronic submandibular sialadenitis

Epivatianos, Apostolos; Harrison, J. D.; Dimitriou, Tatiana

doi:10.1111/j.1600-0714.1987.tb00683.x

Cited by 53 publications

(35 citation statements)

References 11 publications

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“…2 However, the majority are asymptomatic since microcalculi are formed continuously and the majority are shed spontaneously. 3 A more pertinent measure of the problem is not the global prevalence of calculi but rather the incidence of symptomatic stones requiring treatment.…”

Section: Methodsmentioning

confidence: 99%

Symptomatic sialoadenitis and sialolithiasis in the English population, an estimate of the cost of hospital treatment

Escudier¹,

McGurk²

1999

Br Dent J

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RESEARCHeconomics medical provision that serves the remainder. Further, the organisation of the state system is such that operative intervention in the primary care setting is negligible. The vast majority of procedures are undertaken in the secondary or tertiary care sector and a national record of treatment in these sectors is available in the form of hospital admission data by individual ICD code. This provides a method of assessing the incidence of symptomatic salivary disease in the English population.The relevance of this analysis relates to the general desire to move away from invasive surgery and toward minimally invasive procedures. Apart from a reduced morbidity these techniques usually have the added advantage of releasing or reducing demand on in-patient facilities. Minimally invasive methods are now the treatment of choice for urolithiasis with surgical treatment restricted to less than 5% of patients. 4 By adapting these techniques and equipment the technology can be applied to the salivary system and initial steps in this direction have proved promising. 5 The present study was designed to establish the incidence of symptomatic sialoadenitis and sialolithiasis, and to establish if further developments in this field can be driven by financial imperatives. MethodsData were obtained from the Department of Health based on ICD 10 codes and the Hospital Episode Statistics (HES) figures with respect to the 15 health regions in England. This corresponds to a population of 48,532,705 in the census of 1993. The data was corrected at source (DHSS grossing factor) for deficiencies in data collection and referred to all finished consultant episodes (FCEs) for in-patient and day-case admissions in state hospitals. An FCE was defined as a period of patient care under one consultant in one health area. The figures may underestimate the total number of hospital admissions. This is because an individual patient may have been admitted more than once during a treatment episode. Similarly, if the patient transferred to another consultant they would be counted twice. While these sources of error could not be quantified they are believed to have little influence on the overall figures. The ICD 10 codes relating to sialoadenitis and sialolithiasis were interrogated for the years 1991-1995 inclusive. Sialoadenitis was included in the analysis since occult calculi are the underlying cause of adenitis in the majority of cases. 6 Post surgical sialoadenitis is now a rare occurrence.A survey of hospital fees was undertaken to determine the national cost for treating these two conditions. In each health region, three district general hospitals and one teaching hospital, were randomly chosen and the finance manager asked to provide an Objective To establish the annual incidence, and cost of treating, symptomatic salivary stones and sialoadenitis. Materials and methods Data relating to sialolithiasis and sialoadenitis were obtained from the Department of Health with respect to the 15 health regions in England during the period 1...

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Section: Methodsmentioning

confidence: 99%

Symptomatic sialoadenitis and sialolithiasis in the English population, an estimate of the cost of hospital treatment

Escudier¹,

McGurk²

1999

Br Dent J

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“…3 Westhofen et al 12 were first to recognize the presence of microcalcifications in the secretory granules and the acinar lumen, by inducing salivary stimulation and hypercalcemia in rats. Later, Epivantianos et al 10 and Epivantianos and Harrison 13 demonstrated microcalcifications in normal salivary glands of cats and humans, respectively. These microcalculi are lamellated structures made of crystals and amorphous organic material that are thought to represent autophagosomes of redundant secretory vesicles.…”

Section: Commentmentioning

confidence: 98%

“…14 The high-ionized calcium concentration within secretory granules is thought to precipitate the phospholipids of degenerating membranes, resulting in microliths, which measure 2-to 8-µm intracellularly and 15-to 30-µm in the acinar lumen. 10 The calcification of microliths is variable and seems more important in the acini than in the ducts. 15 Glandular inactivity, induced by parasympathectomy in cats, increases the incidence of microliths, mainly in the submandibular gland.…”

Section: Commentmentioning

confidence: 99%

“…3 The first theory is based on the existence of intracellular microcalculi, which when excreted in the canal become a nidus for further calcification. 10 The second theory suggests that "mucous plugs" (Figure 1), which are present in the ductal system, may represent the nidus. Both hypotheses suppose that there is an initial organic nidus that progressively grows by the deposition of layers of inorganic and organic substance.…”

mentioning

confidence: 99%

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Retrograde Theory in Sialolithiasis Formation

Marchal¹,

Kurt²,

Dulguerov³

et al. 2001

Arch Otolaryngol Head Neck Surg

170

139

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“…Apart from local chemical changes in salivary components, the discussed etiologic spectrum for sialolith formation is multiple, comprising not only the formation of microliths but also infectious factors, secretory disturbances, ductal anomalies of the salivary glands and foreign bodies (6,7). Another possible factor is the presence of a sphincter system in Wharton's duct, described in the context of diagnostic sialendoscopy (8,9).…”

mentioning

confidence: 99%

Is there evidence of a sphincter system in Wharton's duct? Etiological factors related to sialolith formation

Teymoortash¹,

Ramaswamy

Werner³

2003

Journal of Oral Science

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Abstract:The exact cause of the formation of sialoliths is unknown. Detailed knowledge of the pathogenesis of sialolithiasis is necessary to define new therapeutic procedures. The possible presence of a sphincter system in Wharton's duct has been described frequently in the context of diagnostic sialendoscopy. Serial histological examination of the entire Wharton's duct in four samples revealed no anatomical correlation for the presence of a sphincter. Secretory disturbances and viscous secretions as well as microlith formation and ductal obstruction cannot fully explain the genesis of sialoliths. The coaction of those factors with participation of bacteria leads to the development of sialoliths. (J. Oral Sci. 45, 233-235, 2003)

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Ultrastructural and histochemical observations on microcalculi in chronic submandibular sialadenitis

Cited by 53 publications

References 11 publications

Symptomatic sialoadenitis and sialolithiasis in the English population, an estimate of the cost of hospital treatment

Symptomatic sialoadenitis and sialolithiasis in the English population, an estimate of the cost of hospital treatment

Retrograde Theory in Sialolithiasis Formation

Is there evidence of a sphincter system in Wharton's duct? Etiological factors related to sialolith formation

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