Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice

Dasgupta, Romi; Chatterji, Urmi; Nag, Tapas Chandra; Chaudhuri-Sengupta, Santasri; Nag, Debabrata; Maiti, B. R.

doi:10.1016/j.mce.2010.01.005

Cited by 31 publications

(19 citation statements)

References 24 publications

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“…Besides, Dasgupta et al (2010) also reported that arecoline could initially stimulate adrenal activity and inhibit the activity eventually, indicating that arecoline might have immunological action via adrenal hormonal suppression in mice.…”

Section: Effects On Endocrine Systemmentioning

confidence: 99%

The pharmacology, toxicology and potential applications of arecoline: a review

Liu

Peng

et al. 2016

Pharmaceutical Biology

114

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Context: Arecoline is an effective constituent of Areca catechu L. (Arecaceae) with various pharmacological effects. However, investigations also revealed that long use of arecoline could arouse some oral diseases. Objective: The present review gathers the fragmented information available in the literature (before 1 October 2015) regarding pharmacology and toxicology of arecoline. We also discussed the potential developments and applications of arecoline in the future. Methods: All the available information regarding the arecoline is compiled from scientific databases, including Science Direct, PubMed, Web of Science, Scopus, etc. Results: Previous research demonstrated that arecoline is one of the major effective constituents in A. catechu. Additionally, arecoline has a wide spectrum of pharmacological activities including effects on nervous, cardiovascular, digestive and endocrine systems and anti-parasitic effects. What's more, arecoline is reported to be the primary toxic constituent of A. catechu, and the main toxic effects include oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC) and genotoxicity. Conclusion: Arecoline has great potential to be a therapeutic drug for various ailments. However, further investigations are needed in the future to reduce or eliminate its toxicities before developing into new drug. ARTICLE HISTORY

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Section: Effects On Endocrine Systemmentioning

confidence: 99%

The pharmacology, toxicology and potential applications of arecoline: a review

Liu

Peng

et al. 2016

Pharmaceutical Biology

114

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“…[34] Following regular areca nut use, the plasma concentration of melatonin decreases and that of serotonin increases. Areca nut causes an increase in testosterone concentration, but, interestingly, this effect is not seen with betel quid usage.…”

Section: Systemic Effects Of Areca Nutmentioning

confidence: 99%

A review of the systemic adverse effects of areca nut or betel nut

Garg

Chaturvedi

Gupta

2014

Indian J Med Paediatr Oncol

222

161

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Areca nut is widely consumed by all ages groups in many parts of the world, especially south-east Asia. The objective of this review is to systematically review and collate all the published data that are related to the systemic effects of areca nut. The literature search was performed by an electronic search of the Pubmed and Cochrane databases using keywords and included articles published till October 2012. We selected studies that covered the effect of areca nut on metabolism, and a total of 62 studies met the criteria. There is substantial evidence for carcinogenicity of areca nut in cancers of the mouth and esophagus. Areca nut affects almost all organs of the human body, including the brain, heart, lungs, gastrointestinal tract and reproductive organs. It causes or aggravates pre-existing conditions such as neuronal injury, myocardial infarction, cardiac arrhythmias, hepatotoxicity, asthma, central obesity, type II diabetes, hyperlipidemia, metabolic syndrome, etc. Areca nut affects the endocrine system, leading to hypothyroidism, prostate hyperplasia and infertility. It affects the immune system leading to suppression of T-cell activity and decreased release of cytokines. It has harmful effects on the fetus when used during pregnancy. Thus, areca nut is not a harmless substance as often perceived and proclaimed by the manufacturers of areca nut products such as Pan Masala, Supari Mix, Betel quid, etc. There is an urgent need to recognize areca nut as a harmful food substance by the policy makers and prohibit its glamorization as a mouth freshener. Strict laws are necessary to regulate the production of commercial preparations of areca nut.

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“…However, no evidence supports that betel quid consumption is associated with thyroid nodules or thyroid cancer. One previous study on rat experiments found that arecoline, a carcinogenic element of betel quid, initially stimulated the thyroid and eventually inhibited the activity; and the chronic arecoline treatment caused light degenerations of thyro-follicular cells [28]. Further studies are required to examine the mechanisms of the association on betel quid and thyroid nodules.…”

Section: Discussionmentioning

confidence: 97%

Thyroid Nodules in Centenarians: Prevalence and Relationship to Lifestyle Characteristics and Dietary Habits

Yao

Chen

et al. 2018

Preprint

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Thyroid nodules (TNs) are common thyroid lesions in older population. Few studies focused on the prevalence of TNs and its relationship to lifestyle characteristics and dietary habits in centenarians. The current study aimed to determine the prevalence of TNs in Chinese centenarians using high-resolution ultrasound equipment and investigate its relationship to lifestyles and dietary habits. The current study was part of China Hainan Centenarian Cohort Study (CHCCS) which conducted in Hainan, an iodine sufficient region in China. A total of 874 permanent residents aged 100 years or older (mean age, 102.8 ± 2.8 years) without any missing data were included in the analysis. Among the participants, 649 of them were detected at least one thyroid nodule under the ultrasound examinations. The overall prevalence rate of TNs was 74.3%. The prevalence of TNs was higher in participants who were females, hypertension, diabetes, and underweight than their counterparts. Multivariate logistic regression analyses showed that being female, hypertension, diabetes, betel quid consumption, red meat consumption were independent risk factors, while being underweight, and nut consumption were independent protective factors for TNs. Our findings indicate that the presence of thyroid nodules was highly prevalent in Chinese centenarians, particularly in females. In addition to gender, hypertension, diabetes, and underweight, the presence of TNs was independently associated with betel quid, red meat, and nut consumptions. Further prospective studies are warranted to verify these associations in population from different age strata, races, cultures, and iodine backgrounds. 2 / 12 IntroductionThyroid nodules (TNs) are common thyroid lesions in older population. High-resolution ultrasonography has made possible the detection of asymptomatic and non-palpable thyroid nodules [1]. The prevalence of TNs detected by high-resolution ultrasonography was 19-68% based on randomly selected individuals, with annual increasing trends worldwide [2,3]. The clinical importance of TNs detection rests with the need to exclude thyroid cancer, which occurs in 5-15% of TN cases [1,4]. A recent study reported that the occurrence of TNs increased as people age, with a prevalence of 74% in a community-based sample of Chinese senior adults [5]. However, the prevalence of this lesion in centenarians remained understudied. Considering the issues mentioned above, there is a need to specifically determine the prevalence of TNs in late life, particularly in centenarians.The high prevalence rate of TNs was partly due to widespread application of high-resolution ultrasound and early diagnosis. In addition, recent studies also proposed that several risk factors could attribute to TNs. Among those risk factors, some factors were non-modifiable such as age, sex, and history of irradiation exposure, while others were modifiable including iodine intake, smoking, alcohol drinking, obesity and metabolic syndrome [5][6][7][8]. However, some other modifiable factors, inc...

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Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice

Cited by 31 publications

References 24 publications

The pharmacology, toxicology and potential applications of arecoline: a review

The pharmacology, toxicology and potential applications of arecoline: a review

A review of the systemic adverse effects of areca nut or betel nut

Thyroid Nodules in Centenarians: Prevalence and Relationship to Lifestyle Characteristics and Dietary Habits

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