1982
DOI: 10.1111/j.1432-0436.1982.tb01201.x
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Ultrastructural Aspects of Erythropoietic Differentiation in Long-term Bone Marrow Culture

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Cited by 79 publications
(48 citation statements)
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“…This in vitro culture demonstrates the formation ex vivo of a hemopoietic niche. It should be noted, however, that the cellular structure that forms in vitro is highly complex and extreme diversity in cell phenotypes, and interactions have been reported to occur in long-term bone marrow cultures [42,43]. Apart from the niche-forming ability of bone marrow stroma, at least a fraction of cells within such stroma possess multipotency, that is, can give rise to a variety of mesodermal cell types [11].…”
Section: Discussionmentioning
confidence: 99%
“…This in vitro culture demonstrates the formation ex vivo of a hemopoietic niche. It should be noted, however, that the cellular structure that forms in vitro is highly complex and extreme diversity in cell phenotypes, and interactions have been reported to occur in long-term bone marrow cultures [42,43]. Apart from the niche-forming ability of bone marrow stroma, at least a fraction of cells within such stroma possess multipotency, that is, can give rise to a variety of mesodermal cell types [11].…”
Section: Discussionmentioning
confidence: 99%
“…This association can be demonstrated both in vivo, following staining of bone marrow with mAbs such as F4/80, and in long-term in vitro bone marrow cultures (20,21). Although these associations are well documented, there is little direct evidence defining the role of macrophages in the developmental regulation of the clustered cells.…”
Section: Msmentioning
confidence: 97%
“…In the erythroblastic islands, a central macrophage provides favorable proliferative and survival signals to the surrounding erythroblasts, and it eventually engulfs the extruded nuclei of maturing erythrocytes. [2][3][4][5] Inhibition of the interaction between macrophage and erythroblasts usually leads to embryonic anemia accompanied by accelerated apoptosis of erythroid cells. Targeted disruption of the gene palld, which encodes actin cytoskeleton associated protein (palladin) prevented effective erythroblast-macrophage interactions because of differentiation defects in the macrophage.…”
Section: Introductionmentioning
confidence: 99%