Ultrastructural Aspects of Primary Biliary Cirrhosis and Other Types of Cholestatic Liver Disease

Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis

“…The increased expression of mitochondrial antigens observed in this study may be consistent with these previous reports; however, these previous reports did not refer to the association with autophagy. We have previously reported the involvement of deregulated autophagy preceding cellular senescence and accumulated autophagic vacuoles in the biliary epithelial lesions in PBC . Taken together, it is plausible that such accumulated autophagic vacuoles resulting from by deregulated autophagy correspond to the granular expression of mitochondrial antigens observed in this study.…”

A possible involvement of p62/sequestosome‐1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis

“…These accumulated autolysosomes may be a result of lysosomal dysfunction. The accumulation of cytophagosomes and lysosomes containing myelin-like structures has been noted in the small bile ducts in PBC, early stage (41,51). The cytophagosomes included autophagosomes and autolysosomes in these reports (41,51).…”

“…The accumulation of cytophagosomes and lysosomes containing myelin‐like structures has been noted in the small bile ducts in PBC, early stage . The cytophagosomes included autophagosomes and autolysosomes in these reports . Therefore, the lysosomal function rather than the early induction of autophagy may be impaired in PBC and the autophagy may be suppressed at the autolysosomal level in the small bile ducts in PBC.…”