Ultrastructural Aspects of the Human Peripheral Vestibular System

Gleeson, Michael; Felix, Heidi; Johnsson, Lars‐Göran

doi:10.3109/00016488909138360

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…This effect is especially critical for examination by transmission electron microscopy with ultrathin sections. There is a differential susceptibility to autolysis within the cell populations in the organ of Corti, and the type I HC, compared with the type II HC, is more susceptible to autolysis (Gleeson et al, 1990). To minimize post‐mortem artifacts in this study, we used temporal bones harvested between 4 and 12 hr post‐mortem.…”

Section: Methodsmentioning

confidence: 99%

Regional estimates of hair cells and supporting cells in the human crista ampullaris

et al. 2005

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Regional estimates of type I and type II vestibular hair cells (HC) and supporting cell (SC) numbers were obtained from the horizontal crista ampullaris by using design-based stereology in human. Cristae were microdissected from temporal bones obtained post-mortem (N=16, age range 26-98 years). Three groups were made according to age: group 1, n=5, ages between 26 and 67 years, average age 51 years; group 2, n=4, average age 84 years; and group 3, n=7, average age 94 years. For group 1, the average total HC number was 8,005+/-214, corresponding to 4,119+/-107 type I HC, 3,886+/-117 type II HC, and 10,274+/-224 SC. The type I:type II HC ratio was 1.06+/-0.01, and HC density was 0.80 cells/100 microm2. For group 2, the average total HC number was 7,074+/-489, corresponding to 3,733+/-212 type I HC, 3,341+/-314 type II HC, and 9,321+/-858 SC. The type I:II HC ratio was 1.12+/-0.06, and HC density was 0.75 cells/100 microm2. For group 3, the average HC number was 6,009+/-327, corresponding to 3,380+/-223 type I HC, 2,628+/-235 type II HC, and 10,185+/-182 SC. The type I:II HC ratio was 1.34+/-0.10, and HC density was 0.63 cells/100 microm2. A significant decline in type I, type II, and total HC number and density was found in groups 2 and 3, with individuals exceeding the average human life span.

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Section: Methodsmentioning

confidence: 99%

Regional estimates of hair cells and supporting cells in the human crista ampullaris

et al. 2005

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“…Some investigators have used electron microscopy to study vestibular hair cells in human temporal bones 13‐15 . These studies have focused on determining the relative distribution of type I versus type II hair cells.…”

Section: Review Of Literature: Vestibular Hair Cellsmentioning

confidence: 99%

A Method for Quantitative Assessment of Vestibular Otopathology

Merchant

1999

The Laryngoscope

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The method described in this report has several advantages when compared with alternative techniques such as surface preparations. The method is applicable to archival bones, permits simultaneous evaluation of the rest of the labyrinth, is relatively inexpensive, and does not preclude other techniques of study (e.g., polymerase chain reaction and immunostaining). Case studies of temporal bones with aminoglycoside ototoxicity and Meniere's disease are used to show how this method has the potential to provide new insight into the pathology and pathophysiology of vestibular disorders.

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“…Lipoxins stimulate monocytes without causing the inflammatory release of ROS [251]. Lipoxins may also promote the phagocytosis of apoptotic neutrophils by macrophages, thereby reducing inflammation [252]. Accumulating evidence suggests the anti-inflammatory effect of lipoxin A 4 (LXA 4 ) in inflammation-associated cancers such as colorectal cancer [253].…”

Section: Lipoxygenase (Lox) Signalingmentioning

confidence: 99%

Targeting inflammation as cancer therapy

Wang,

Chen,

et al. 2024

J Hematol Oncol

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Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous efforts have been undertaken to explore the potential role of inflammation in cancer, from tumor development, invasion, and metastasis to the resistance of tumors to treatment. Inflammation-targeted agents not only demonstrate the potential to suppress cancer development, but also to improve the efficacy of other therapeutic modalities. In this review, we describe the highly dynamic and complex inflammatory tumor microenvironment, with discussion on key inflammation mediators in cancer including inflammatory cells, inflammatory cytokines, and their downstream intracellular pathways. In addition, we especially address the role of inflammation in cancer development and highlight the action mechanisms of inflammation-targeted therapies in antitumor response. Finally, we summarize the results from both preclinical and clinical studies up to date to illustrate the translation potential of inflammation-targeted therapies.

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Ultrastructural Aspects of the Human Peripheral Vestibular System

Cited by 7 publications

References 27 publications

Regional estimates of hair cells and supporting cells in the human crista ampullaris

Regional estimates of hair cells and supporting cells in the human crista ampullaris

A Method for Quantitative Assessment of Vestibular Otopathology

Targeting inflammation as cancer therapy

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