Ultrastructural biomarker responses in gill tissues of Cirrhinus mrigala (Hamilton, 1822) through SEM after exposure to zinc sulphate

Sharma, Dheeraj; Gandotra, Roopma; Dhiman, Shakti Kumar; Arif, Mohd; Dogra, Aayushi; Lone, Aaqib; Choudhary, Neha; Choudhary, Poonam

doi:10.1016/j.ejar.2021.03.003

Cited by 10 publications

(2 citation statements)

References 19 publications

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“…Tubular degeneration in adults and embryos of zebrafish was reported while investigating the acute toxicity of Libidibia ferrea, a traditional anti-inflammatory source [33] . Tubular degeneration, vacuolation, glomerular shrinkage with dilated Bowman's space, and necrosis were observed in freshwater fish Catla catla when treated with cypermethrin [34] . The striped catfish Pangasianodon hypophthalmus exposed to chromium also caused structural changes such as renal corpuscle shrinkage, Bowman's space dilation, and necrosis [35] .…”

Section: Table 1: Lc 50 Of Egcg and C-pc For Various Duration (24 H 4...mentioning

confidence: 98%

Acute Toxicity of Epigallocatechin Gallate and C-Phycocyanin in Zebrafish (Danio rerio): Behavioral and Histopathological Studies

Jamir,

Longkumer,

Punj

2024

IJPS

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Acute Toxicity of Epigallocatechin Gallate and C-Phycocyanin in ZebrafishEpigallocatechin gallate and C-phycocyanin are natural food supplements, gaining a lot of popularity in biomedical researches. The lethal concentration 50 value for the zebrafish model was determined using a 96 h semi-static acute toxicity test. Zebrafish were transferred into a 1 l water tank starting with a minimal dose of 8 mg of epigallocatechin gallate and 1 g of C-phycocyanin, which further increased to the concentration of 30 mg for epigallocatechin gallate and 5 g for C-phycocyanin. Lethal concentration 50 of epigallocatechin gallate and C-phycocyanin was calculated to be 21.37 mg/l and 2.45 g/l respectively at 96 h in the zebrafish model. At high doses above 12 mg of epigallocatechin gallate and 1 g of C-phycocyanin, the test fish displayed various behavior responses like erratic and jerky swimming, attempts to jump out of the water, frequent surfacing and swallowing of air, normal skin color change, decreased opercular movement and finally leading to death. Histological observations showed hypertrophy, atrophy and vacuolar degeneration in the liver whereas tubular degeneration, glomerular hyper cellularity, dilation of Bowman's space, hemorrhage, and necrosis were observed in the kidneys exposed to the high doses of epigallocatechin gallate and C-phycocyanin treated fish. The gills of the test animals also expressed lamellar synechiae, hyperplasia, curling of lamellae, mucus secretion and shortening of the secondary lamella. The results demonstrated that doses above 30 mg/l and 5 g/l in the case of epigallocatechin gallate and C-phycocyanin respectively gave 100 % mortality and expressed organ-specific toxicity. Overall results revealed that exposure to high concentrations of epigallocatechin gallate and C-phycocyanin uninterruptedly may lead to severe alterations in the tissue of experimental animals.

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Section: Table 1: Lc 50 Of Egcg and C-pc For Various Duration (24 H 4...mentioning

confidence: 98%

Acute Toxicity of Epigallocatechin Gallate and C-Phycocyanin in Zebrafish (Danio rerio): Behavioral and Histopathological Studies

Jamir,

Longkumer,

Punj

2024

IJPS

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“…Recent advancements in drug development have improved the quality of life in humans as well as animals and have also increased the average life span of both; therefore increasing population growth rate is directly related with increased usage of pharmaceutical compounds and ultimately increasing their amount in aquatic environment which is a major cause of concern. The existence of pharmaceutical compounds can make recovery of water a complex process (Delecka et al 2020).Although the international scienti c community is making reasonable attempts to curtail the problem of traditional contaminants such as organic matter, heavy metals like zinc which also pose serious threat to aquatic fauna such as shes (Sharma et al 2021), other environmental contaminants popularly known as emerging contaminants (ECs) are of rising concern now a days (Carmalin,A. et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Assessment of diclofenac in three selected rivers of Western Himalayan Region

Sharma

Choudhary

Gandotra

2023

Preprint

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The present study reports the concentration of Non-steroidal anti- inflammatory drug (NSAID), Diclofenac in three main rivers namely Sarsa, Sutluj and Ravi of Western-Himalayan region. Diclofenac was analyzed from water samples using UPLC-S/MS system. The concentration ranged between 0- 2.05ng/l, the maximum concentration was observed in Badhi (S1) due to presence of number of pharmaceutical industries. The concentrations of diclofenac reported in the current study were comparatively very low as observed in other studies worldwide. This is the first report on the occurrence of diclofenac in the rivers of Western Himalayan region.

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Biosorption of heavy metal ions from aqueous effluents utilising snail shell dust as a biomaterial

Sharma,

Devi

2024

Environ Dev Sustain

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Ultrastructural biomarker responses in gill tissues of Cirrhinus mrigala (Hamilton, 1822) through SEM after exposure to zinc sulphate

Cited by 10 publications

References 19 publications

Acute Toxicity of Epigallocatechin Gallate and C-Phycocyanin in Zebrafish (Danio rerio): Behavioral and Histopathological Studies

Acute Toxicity of Epigallocatechin Gallate and C-Phycocyanin in Zebrafish (Danio rerio): Behavioral and Histopathological Studies

Assessment of diclofenac in three selected rivers of Western Himalayan Region

Biosorption of heavy metal ions from aqueous effluents utilising snail shell dust as a biomaterial

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